Search Results - "Tretbar, Sandy"

Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality by von Auw, Nadine, Serfling, Robert, Kitte, Reni, Hilger, Nadja, Zhang, Chengkang, Gebhardt, Clara, Duenkel, Anna, Franz, Paul, Koehl, Ulrike, Fricke, Stephan, Tretbar, U. Sandy

“…Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell…”
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CAR T cells for treating autoimmune diseases by Blache, Ulrich, Tretbar, Sandy, Koehl, Ulrike, Mougiakakos, Dimitrios, Fricke, Stephan

“…Autoimmune disorders occur when immune cells go wrong and attack the body’s own tissues. Currently, autoimmune disorders are largely treated by broad…”
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Conformational dynamics of stem II of the U2 snRNA by Rodgers, Margaret L, Tretbar, U Sandy, Dehaven, Alexander, Alwan, Amir A, Luo, George, Mast, Hannah M, Hoskins, Aaron A

“…The spliceosome undergoes dramatic changes in both small nuclear RNA (snRNA) composition and structure during assembly and pre-mRNA splicing. It has been…”
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Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids by Beckmann, Lorenz, Tretbar, Uta Sandy, Kitte, Reni, Tretbar, Maik

“…Drimane and coloratane sesquiterpenoids are present in several plants, microorganisms, and marine life. Because of their cytotoxic activity, these…”
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inhibitory C-terminal region dictates the specificity of A-adding enzymes by Tretbar, Sandy, Neuenfeldt, Anne, Betat, Heike, Mörl, Mario

“…For efficient aminoacylation, tRNAs carry the conserved 3'-terminal sequence C-C-A, which is synthesized by highly specific tRNA nucleotidyltransferases…”
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Humanized mouse model: Hematopoietic stemcell transplantation and tracking using short tandem repeat technology by Walcher, Lia, Hilger, Nadja, Wege, Anja K., Lange, Franziska, Tretbar, U. Sandy, Blaudszun, André‐René, Fricke, Stephan

“…Introduction Models of mice carrying a human immune system, so‐called humanized mice, are used increasingly as preclinical models to bridge the gap between…”
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CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma by Ciulean, Ioana Sonya, Fischer, Joe, Quaiser, Andrea, Bach, Christoph, Abken, Hinrich, Tretbar, Uta Sandy, Fricke, Stephan, Koehl, Ulrike, Schmiedel, Dominik, Grunwald, Thomas

“…Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however,…”
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The Epitope-Specific Anti-human CD4 Antibody MAX.16H5 and Its Role in Immune Tolerance by Stahl, Lilly, Duenkel, Anna, Hilger, Nadja, Tretbar, Uta Sandy, Fricke, Stephan

“…T cell modulation in the clinical background of autoimmune diseases or allogeneic cell and organ transplantations with concurrent preservation of their natural…”
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Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing by Walcher, Lia, Kistenmacher, Ann-Kathrin, Sommer, Charline, Böhlen, Sebastian, Ziemann, Christina, Dehmel, Susann, Braun, Armin, Tretbar, Uta Sandy, Klöß, Stephan, Schambach, Axel, Morgan, Michael, Löffler, Dennis, Kämpf, Christoph, Blumert, Conny, Reiche, Kristin, Beckmann, Jana, König, Ulla, Standfest, Bastian, Thoma, Martin, Makert, Gustavo R., Ulbert, Sebastian, Kossatz-Böhlert, Uta, Köhl, Ulrike, Dünkel, Anna, Fricke, Stephan

“…BackgroundWith increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient…”
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Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering by Kitte, Reni, Rabel, Martin, Geczy, Reka, Park, Stella, Fricke, Stephan, Koehl, Ulrike, Tretbar, U. Sandy

“…Engineered T cells expressing chimeric antigen receptors (CARs) have been proven as efficacious therapies against selected hematological malignancies. However,…”
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Identification and characterization of novel CD274 (PD‐L1) regulating microRNAs and their functional relevance in melanoma by Vaxevanis, Christoforos K., Friedrich, Michael, Tretbar, Sandy Uta, Handke, Diana, Wang, Yuan, Blümke, Juliane, Dummer, Reinhard, Massa, Chiara, Seliger, Barbara

“…Background Immune checkpoint inhibitors directed against programmed cell death 1 (PDCD1/PD1) receptor and programmed cell death‐ligand 1 (CD274/PD‐L1) have…”
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Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis by Kitte, Reni, Tretbar, Maik, Dluczek, Sarah, Beckmann, Lorenz, Marquardt, Peter, Duenkel, Anna, Schubert, Andreas, Fricke, Stephan, Tretbar, U. Sandy

“…[Display omitted] •Three sesquiterpenoids are efficiently isolated from Warburgia ugandensis stem bark in one process under mild conditions.•Warburgia…”
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Dynamics of the DEAD-box ATPase Prp5 RecA-like domains provide a conformational switch during spliceosome assembly by Beier, David H, Carrocci, Tucker J, van der Feltz, Clarisse, Tretbar, U Sandy, Paulson, Joshua C, Grabowski, Nikolai, Hoskins, Aaron A

“…Abstract The DEAD-box family of proteins are ATP-dependent, RNA-binding proteins implicated in many aspects of RNA metabolism. Pre-mRNA splicing in eukaryotes…”
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Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy by Friedrich, Michael, Jasinski-Bergner, Simon, Lazaridou, Maria-Filothei, Subbarayan, Karthikeyan, Massa, Chiara, Tretbar, Sandy, Mueller, Anja, Handke, Diana, Biehl, Katharina, Bukur, Jürgen, Donia, Marco, Mandelboim, Ofer, Seliger, Barbara

“…Immunotherapy aims to activate the immune system to fight cancer in a very specific and targeted manner. Despite the success of different immunotherapeutic…”
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MRNA Technology for the Development of Car T Cells Targeting Fibrotic Diseases by Brauning, Sandro, Schiefer, Denise, Moser, Christin, Greiser, Sebastian, Fricke, Stephan, Kohl, Ulrike, Blache, Ulrich, Tretbar, Sandy

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MRNA Technology for the Development of Car T Cells Targeting Fibrotic Diseases by Brauning, Sandro, Schiefer, Denise, Moser, Christin, Greiser, Sebastian, Fricke, Stephan, Kohl, Ulrike, Blache, Ulrich, Tretbar, Sandy

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TGF-β inducible epithelial-to-mesenchymal transition in renal cell carcinoma by Tretbar, Sandy, Krausbeck, Peter, Müller, Anja, Friedrich, Michael, Vaxevanis, Christoforos, Bukur, Juergen, Jasinski-Bergner, Simon, Seliger, Barbara

“…Epithelial-to-mesenchymal transition (EMT) is a crucial step in cancer progression and the number one reason for poor prognosis and worse overall survival of…”
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The ancestor of modern Holozoa acquired the CCA-adding enzyme from Alphaproteobacteria by horizontal gene transfer by Betat, Heike, Mede, Tobias, Tretbar, Sandy, Steiner, Lydia, Stadler, Peter F, Mörl, Mario, Prohaska, Sonja J

“…Transfer RNAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends, representing the site of aminoacylation. In the majority of…”
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Identification of microRNAs Targeting the Transporter Associated with Antigen Processing TAP1 in Melanoma by Lazaridou, Maria-Filothei, Massa, Chiara, Handke, Diana, Mueller, Anja, Friedrich, Michael, Subbarayan, Karthikeyan, Tretbar, Sandy, Dummer, Reinhard, Koelblinger, Peter, Seliger, Barbara

“…The underlying molecular mechanisms of the aberrant expression of components of the HLA class I antigen processing and presentation machinery (APM) in tumors…”
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The TRAMP complex shows tRNA editing activity in S. cerevisiae by Dickinson, Helena, Tretbar, Sandy, Betat, Heike, Mörl, Mario

“…Transfer RNA (tRNA) editing is a widespread processing phenomenon that alters the sequence of primary transcripts by base substitutions as well as nucleotide…”
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