Evaluation of Renal Grafts in Patients With Lupus Nephritis as Cause of End-Stage Renal Disease

Kidney transplantation is the best option in end-stage renal disease (ESRD). For many years patients affected with lupus nephritis have had poor graft results. However, this has been changing over recent years with the development of new immunosuppressive drugs and a better comprehension of the natu...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 37; no. 3; pp. 1426 - 1427
Main Authors:	Villaverde Verdejo, P., Fernández Rivera, C., Alonso Hernández, A., Garcia Naveiro, R., Vilariño, M. Cao, Tresancos Fernández, C., Valdés Cañedo, F.
Format:	Journal Article Conference Proceeding
Language:	English
Published:	New York, NY Elsevier Inc 01-04-2005 Elsevier Science
Subjects:	Adult Biological and medical sciences Drug Administration Schedule Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - epidemiology Humans Immunosuppressive Agents - therapeutic use Kidney Failure, Chronic - etiology Kidney Failure, Chronic - surgery Kidney Transplantation - immunology Kidney Transplantation - pathology Kidney Transplantation - physiology Lupus Erythematosus, Systemic Lupus Nephritis - surgery Male Medical sciences Postoperative Complications - classification Postoperative Complications - epidemiology Reoperation Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombosis - epidemiology Tissue, organ and graft immunology Transplantation Conditioning - methods Treatment Outcome Kidney disease Human Connective tissue disease Evaluation Skin disease Urinary system disease Autoimmune disease Patient Transplantation Homotransplantation Medicine Systemic lupus erythematosus Nephropathy Treatment Urinary system Surgery Systemic disease Renal failure Graft
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Summary:	Kidney transplantation is the best option in end-stage renal disease (ESRD). For many years patients affected with lupus nephritis have had poor graft results. However, this has been changing over recent years with the development of new immunosuppressive drugs and a better comprehension of the natural evolution of the entity. We studied 20 patients with lupus nephritis who received 22 kidney grafts: 15 women and five men ( n = 11) who were treated with cyclosporine or with tacrolimus ( n = 11). Secondary immunosuppression included mycophenolate match (MMF) ( n = 13) or azathioprine ( n = 9). We analyzed human leukocyte antigen, cold ischemia time, acute tubular necrosis, creatinine, cholesterol, triglycerides, glucose, blood pressure, acute rejection episodes, immunosuppression, infections, disease recurrences, as well as graft and patient survival. After a mean cold ischemia time of 22 ± 4 hours, nine patients displayed delayed graft function of an average duration 9 ± 4 days. At 36 ± 35 months nine grafts were lost: two due to acute rejection; five to chronic allograft nephropathy; and two to venous thrombosis. One patient died of hemorrhagic shock. There were five cytomegalovirus infections. Graft survival was dependent on the type of secondary immunosuppression, incidence of acute rejection episodes and occurrence of delayed graft function. We found no clinical recurrence of lupus nephritis after transplantation and a low incidence of complications, although there was a trend toward thrombosis. The presence of delayed graft function, episodes of acute rejection, and receiving azathioprine instead of MMF as secondary immunosuppression were associated with poorer graft survival.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2005.02.062