Search Results - "Trepel, Jane"

Structural and functional complexity of HSP90 in cellular homeostasis and disease by Chiosis, Gabriela, Digwal, Chander S., Trepel, Jane B., Neckers, Len

“…Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A…”
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Targeting the dynamic HSP90 complex in cancer by Neckers, Len, Trepel, Jane, Mollapour, Mehdi, Giaccone, Giuseppe

“…Key Points Heat shock protein 90 (HSP90) is a molecular chaperone of numerous oncoproteins. Therefore, cancer cells can be considered to be 'addicted' to this…”
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Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors by Yuno, Akira, Lee, Min-Jung, Lee, Sunmin, Tomita, Yusuke, Rekhtman, David, Moore, Brittni, Trepel, Jane B

“…Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) have been in clinical development as anticancer agents since 1998. There have been 18 Hsp90…”
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Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor by YARDLEY, Denise A, ISMAIL-KHAN, Roohi R, MELICHAR, Bohuslav, LICHINITSER, Mikhail, MUNSTER, Pamela N, KLEIN, Pamela M, CRUICKSHANK, Scott, MILLER, Kathy D, LEE, Min J, TREPEL, Jane B

“…Entinostat is an oral isoform selective histone deacetylase inhibitor that targets resistance to hormonal therapies in estrogen receptor-positive (ER+) breast…”
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Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer by Roper, Nitin, Velez, Moises J., Chiappori, Alberto, Kim, Yoo Sun, Wei, Jun S., Sindiri, Sivasish, Takahashi, Nobuyuki, Mulford, Deborah, Kumar, Suresh, Ylaya, Kris, Trindade, Christopher, Manukyan, Irena, Brown, Anna-Leigh, Trepel, Jane B., Lee, Jung-Min, Hewitt, Stephen, Khan, Javed, Thomas, Anish

“…Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC), yet the mechanisms driving benefit are poorly…”
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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development by Neckers, Len, Blagg, Brian, Haystead, Timothy, Trepel, Jane B., Whitesell, Luke, Picard, Didier

“…The molecular chaperone Hsp90 is one component of a highly complex and interactive cellular proteostasis network (PN) that participates in protein folding,…”
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Stressing the Development of Small Molecules Targeting HSP90 by NECKERS, Len, TREPEL, Jane B

“…Inhibitors of the molecular chaperone HSP90 have been in clinical development as anticancer agents since 1999. Recent clinical studies, including the work of…”
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Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study by Lee, Jung-Min, Nair, Jayakumar, Zimmer, Alexandra, Lipkowitz, Stanley, Annunziata, Christina M, Merino, Maria J, Swisher, Elizabeth M, Harrell, Maria I, Trepel, Jane B, Lee, Min-Jung, Bagheri, Mohammad H, Botesteanu, Dana-Adriana, Steinberg, Seth M, Minasian, Lori, Ekwede, Irene, Kohn, Elise C

“…High-grade serous ovarian carcinoma is characterised by TP53 mutations, DNA repair defects, and genomic instability. We hypothesised that prexasertib…”
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Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity by Ogawa, Mikako, Tomita, Yusuke, Nakamura, Yuko, Lee, Min-Jung, Lee, Sunmin, Tomita, Saori, Nagaya, Tadanobu, Sato, Kazuhide, Yamauchi, Toyohiko, Iwai, Hidenao, Kumar, Abhishek, Haystead, Timothy, Shroff, Hari, Choyke, Peter L, Trepel, Jane B, Kobayashi, Hisataka

“…Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via…”
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Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study by Thomas, Anish, Vilimas, Rasa, Trindade, Christopher, Erwin-Cohen, Rebecca, Roper, Nitin, Xi, Liqiang, Krishnasamy, Venkatesh, Levy, Elliot, Mammen, Andy, Nichols, Samantha, Chen, Yuanbin, Velcheti, Vamsidhar, Yin, Faye, Szabo, Eva, Pommier, Yves, Steinberg, Seth M, Trepel, Jane B, Raffeld, Mark, Young, Howard A, Khan, Javed, Hewitt, Stephen, Lee, Jung-Min

“…Despite high tumor mutationburden, immune checkpoint blockade has limited efficacy in SCLC. We hypothesized that poly (ADP-ribose) polymerase inhibition could…”
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Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity by Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W., Xu, Wanping, Vaughan, Cara K., Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W., Trepel, Jane B., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len

“…Heat shock protein 90 (Hsp90) is an essential molecular chaperone whose activity is regulated not only by cochaperones but also by distinct posttranslational…”
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A brief review of the management of platinum-resistant–platinum-refractory ovarian cancer by Oronsky, Bryan, Ray, Carolyn M., Spira, Alexander I., Trepel, Jane B., Carter, Corey A., Cottrill, Hope M.

“…Ovarian cancer, which ranks fifth in cancer deaths among women, is the most lethal gynecologic malignancy. Epithelial ovarian cancer (EOC) is the most common…”
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Temozolomide in the Era of Precision Medicine by Thomas, Anish, Tanaka, Mamoru, Trepel, Jane, Reinhold, William C, Rajapakse, Vinodh N, Pommier, Yves

“…In the January 1, 2017, issue of , Nagel and colleagues demonstrate the value of assays that determine the DNA repair capacity of cancers in predicting…”
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Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer by Moses, Michael A, Kim, Yeong Sang, Rivera-Marquez, Genesis M, Oshima, Nobu, Watson, Matthew J, Beebe, Kristin E, Wells, Catherine, Lee, Sunmin, Zuehlke, Abbey D, Shao, Hao, Bingman, 3rd, William E, Kumar, Vineet, Malhotra, Sanjay V, Weigel, Nancy L, Gestwicki, Jason E, Trepel, Jane B, Neckers, Leonard M

“…Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen receptor (AR) signaling, in part by elevated expression of AR splice…”
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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation by Kijima, Toshiki, Prince, Thomas L., Tigue, Megan L., Yim, Kendrick H., Schwartz, Harvey, Beebe, Kristin, Lee, Sunmin, Budzynski, Marek A., Williams, Heinric, Trepel, Jane B., Sistonen, Lea, Calderwood, Stuart, Neckers, Len

“…Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program…”
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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress by Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N, Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M, Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W, Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E, Kindrick, Jessica D, Peer, Cody J, Wei, Jun S, Aladjem, Mirit I, Figg, William Douglas, Steinberg, Seth M, Trepel, Jane B, Zenke, Frank T, Pommier, Yves, Khan, Javed, Thomas, Craig J

“…Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse primary sites that lack effective treatments. Using chemical genetic…”
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RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB by Reinhold, William C, Varma, Sudhir, Sunshine, Margot, Elloumi, Fathi, Ofori-Atta, Kwabena, Lee, Sunmin, Trepel, Jane B, Meltzer, Paul S, Doroshow, James H, Pommier, Yves

“…CellMiner (http://discover.nci.nih.gov/cellminer) and CellMinerCDB (https://discover.nci.nih.gov/cellminercdb/) are web-based applications for mining publicly…”
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Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 ( SLFN11) Expression with Class I Histone Deacetylase Inhibitors by Tang, Sai-Wen, Thomas, Anish, Murai, Junko, Trepel, Jane B, Bates, Susan E, Rajapakse, Vinodh N, Pommier, Yves

“…Schlafen 11 (SLFN11), a putative DNA/RNA helicase is a dominant genomic determinant of response to DNA-damaging agents and is frequently not expressed in…”
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Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors by Mollapour, Mehdi, Bourboulia, Dimitra, Beebe, Kristin, Woodford, Mark R., Polier, Sigrun, Hoang, Anthony, Chelluri, Raju, Li, Yu, Guo, Ailan, Lee, Min-Jung, Fotooh-Abadi, Elham, Khan, Sahar, Prince, Thomas, Miyajima, Naoto, Yoshida, Soichiro, Tsutsumi, Shinji, Xu, Wanping, Panaretou, Barry, Stetler-Stevenson, William G., Bratslavsky, Gennady, Trepel, Jane B., Prodromou, Chrisostomos, Neckers, Len

“…The stability and activity of numerous signaling proteins in both normal and cancer cells depends on the dimeric molecular chaperone heat shock protein 90…”
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Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti-PD-(L)1 Therapy by Hellmann, Matthew D, Jänne, Pasi A, Opyrchal, Mateusz, Hafez, Navid, Raez, Luis E, Gabrilovich, Dmitry I, Wang, Fang, Trepel, Jane B, Lee, Min-Jung, Yuno, Akira, Lee, Sunmin, Brouwer, Susan, Sankoh, Serap, Wang, Lei, Tamang, David, Schmidt, Emmett V, Meyers, Michael L, Ramalingam, Suresh S, Shum, Elaine, Ordentlich, Peter

“…New therapies are needed to treat immune checkpoint inhibitor-resistant non-small cell lung cancer (NSCLC) and identify biomarkers to personalize treatment…”
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