Search Results - "Trepel, JB"

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy by BLAGOSKLONNY, M. V, FOJO, T, BHALLA, K. N, KIM, J-S, TREPEL, J. B, FIGG, W. D, RIVERA, Y, NECKERS, L. M

“…The Bcr-Abl fusion protein drives leukemogenesis and can render leukemia cells resistant to conventional chemotherapy. Geldanamycin (GA), a drug which…”
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Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer by Duffy, A.G., Makarova‐Rusher, O.V., Ulahannan, S.V., Rahma, O.E., Fioravanti, S., Walker, M., Abdullah, S., Raffeld, M., Anderson, V., Abi‐Jaoudeh, N., Levy, E., Wood, B.J., Lee, S., Tomita, Y., Trepel, J.B., Steinberg, S.M., Revenko, A.S., MacLeod, A.R., Peer, C.J., Figg, W.D., Greten, T.F.

“…The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal…”
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Abstract P2-11-10: Epigenetic immune modulation by entinostat in breast cancer: Correlative analysis of ENCORE 301 trial by Chumsri, S, Lee, M-J, Tomita, Y, Lee, S, Tomita, S, Cruickshank, S, Ordentlich, P, Trepel, JB

“…Background: Entinostat, a class I HDAC inhibitor (HDACi), has shown promising activity in ENCORE 301, a randomized, placebo-controlled, phase II trial of…”
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Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma by RYAN, Qin C, HEADLEE, Donna, MELILLO, Giovanni, ELSAYED, Yusri, MONGA, Manish, KALNITSKIY, Mikhail, ZWIEBEL, James, SAUSVILLE, Edward A, ACHARYA, Milin, SPARREBOOM, Alex, TREPEL, Jane B, YE, Joseph, FIGG, William D, HWANG, Kyunghwa, EUN JOO CHUNG, MURGO, Anthony

“…The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose-limiting toxicity, and determine the…”
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Enhanced Radiation-Induced Cell Killing and Prolongation of γH2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275 by Camphausen, Kevin, Burgan, William, Cerra, Michael, Oswald, Kelli A., Trepel, Jane B., Lee, Min-Jung, Tofilon, Philip J.

“…Histone deacetylase (HDAC) inhibitors are undergoing clinical evaluation for cancer therapy. Because HDAC modulates chromatin structure and gene expression,…”
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MPAPASS software enables stitched multiplex, multidimensional EV repertoire analysis and a standard framework for reporting bead-based assays by Welsh, Joshua A., Killingsworth, Bryce, Kepley, Julia, Traynor, Tim, Cook, Sean, Savage, Jason, Marte, Jenn, Lee, Min-Jung, Maeng, Hoyoung M., Pleet, Michelle L., Magana, Setty, Gorgens, André, Maire, Cecile L., Lamszus, Katrin, Ricklefs, Franz L., Merino, Maria J., Linehan, W. Marston, Greten, Tim, Cooks, Tomer, Harris, Curtis C., Apolo, Andrea, Abdel-Mageed, Asim, Ivanov, Alexander R., Trepel, Jane B., Roth, Matthew, Tkach, Mercedes, Milosavljevic, Aleksandar, Théry, Clotilde, LeBlanc, Amy, Berzofsky, Jay A., Ruppin, Eytan, Aldape, Kenneth, Camphausen, Kevin, Gulley, James L., Ghiran, Ionita, Jacobson, Steve, Jones, Jennifer C.

“…Extracellular vesicles (EVs) of various types are released or shed from all cells. EVs carry proteins and contain additional protein and nucleic acid cargo…”
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Impact of extracellular folate levels on global gene expression by Jhaveri, M S, Wagner, C, Trepel, J B

“…Methylation of DNA is associated with gene silencing. DNA methylation uses S-adenosylmethionine (SAM) as the methyl donor and the formation of SAM requires a…”
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Antisense oligonucleotides targeted to the human α folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment by Jhaveri, Mona S, Rait, Antonina S, Chung, Koong-Nah, Trepel, Jane B, Chang, Esther H

“…Folates are essential for cell survival and are required for numerous biochemical processes. The human α isoform folate receptor (αhFR) has a very high…”
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Abrogation of p21 Expression by Flavopiridol Enhances Depsipeptide-Mediated Apoptosis in Malignant Pleural Mesothelioma Cells by NGUYEN, Dao M, SCHRUMP, William D, CHEN, G. Aaron, TSAI, Wilson, NGUYEN, Phuongmai, TREPEL, Jane B, SCHRUMP, David S

“…Purpose: Recent insights regarding the pathogenesis of malignant pleural mesothelioma (MPM) provide new opportunities for targeted molecular therapies for this…”
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Regulation of leukemic cell adhesion, proliferation, and survival by β-catenin by Chung, Eun Joo, Hwang, Sang-Gu, Nguyen, PhuongMai, Lee, Sunmin, Kim, Jung-Sik, Kim, Jin Woo, Henkart, Pierre A., Bottaro, Donald P., Soon, Lilian, Bonvini, Paolo, Lee, Su-Jae, Karp, Judith E., Oh, Ho Jung, Rubin, Jeffrey S., Trepel, Jane B.

“…In epithelial cells β-catenin plays a critical role as a component of the cell-cell adhesion apparatus and as a coactivator of the TCF/LEF (T-cell…”
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Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models by Shibata, Masa-Aki, Kavanaugh, Claudine, Shibata, Eiko, Abe, Hideaki, Nguyen, PhuongMai, Otsuki, Yoshinori, Trepel, Jane B., Green, Jeffrey E.

“…The effects of lovastatin, a potent inhibitor of HMG CoA reductase, on experimental mammary and prostate oncogenesis, were studied in vitro and in vivo…”
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DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation by Sun, Lunching, Huang, Lei, Nguyen, Phuongmai, Bisht, Kheem S, Bar-Sela, Gil, Ho, Allen S, Bradbury, C Matthew, Yu, Wenqiang, Cui, Hengmi, Lee, Sunmin, Trepel, Jane B, Feinberg, Andrew P, Gius, David

“…In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes…”
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DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells by TRAPANI, V, PATEL, V, LEONG, C.-O, CIOLINO, H. P, YEH, G. C, HOSE, C, TREPEL, J. B, STEVENS, M. F. G, SAUSVILLE, E. A, LOAIZA-PEREZ, A. I

“…The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is a novel agent with potent and selective…”
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Aryl hydrocarbon receptor activation of an antitumor aminoflavone: Basis of selective toxicity for MCF-7 breast tumor cells by Loaiza-Pérez, Andrea I, Kenney, Susan, Boswell, Jamie, Hollingshead, Melinda, Alley, Michael C, Hose, Curtis, Ciolino, Henry P, Yeh, Grace C, Trepel, Jane B, Vistica, David T, Sausville, Edward A

“…Aminoflavone (4H-1-benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl; NSC 686288) demonstrates differential antiproliferative activity…”
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A phase II study of perifosine in androgen independent prostate cancer by Posadas, Edwin M., Gulley, James L., Arlen, Philip M., Trout, Alisa, Parnes, Howard L., Wright, John, Lee, Min-Jung, Chung, Eun Joo, Trepel, Jane B., Sparreboom, Alex, Chen, Clara, Jones, Elizabeth, Steinberg, Seth M., Daniels, Andrew, Figg, II, William, Dahut, William L.

“…OBJECTIVES: Perifosine is an alkylphospholipid that has exhibited broad antineoplastic activity in preclinical studies. The primary objective of this study was…”
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Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling by MOUSSES, Spyro, WAGNER, Urs, YIDONG CHEN, KIM, J. W, BUBENDORF, Lukas, BITTNER, Michael, PRETLOW, Thomas, ELKAHLOUN, Abdel G, TREPEL, Jane B, KALLIONIEMI, Olli-P

“…Androgen deprivation therapy for advanced prostate cancer is often effective, but not curative. Molecular pathways mediating the therapeutic response and those…”
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Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole by Loaiza-Pérez, Andrea I, Trapani, Valentina, Hose, Curtis, Singh, Sheo S, Trepel, Jane B, Stevens, Malcolm F G, Bradshaw, Tracey D, Sausville, Edward A

“…2-(4-Amino-3-methylphenyl) benzothiazole (NSC 674495; DF 203) demonstrates drug uptake and metabolism by tumor cells sensitive to the antiproliferative…”
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MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor β type II receptor expression in human breast cancer cells by BYOUNG ICK LEE, SEOK HEE PARK, JIN WOO KIM, SAUSVILLE, Edward A, HEUNG TAE KIM, NAKANISHI, Osamu, TREPEL, Jane B, KIM, Seong-Jin

“…Transcriptional repression of the transforming growth factor (TGF)-1P type II receptor (TPRII) gene appears to be a major mechanism to inactivate TGF-beta…”
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Protease inhibitor-induced apoptosis : accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition by AN, W. G, HWANG, S.-G, TREPEL, J. B, BLAGOSKLONNY, M. V

“…Inhibitors of proteases are currently emerging as a potential anti-cancer modality. Nonselective protease inhibitors are cytotoxic to leukemia and cancer cell…”
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Sequential 5-Aza 2′-deoxycytidine depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells by STEINER, Federico A, HONG, Julie A, TREPEL, Jane B, SCHRUMP, David S, FISCHETTE, Maria R, BEER, David G, GUO, Zong-Sheng, CHEN, G. Aaron, WEISER, Todd S, KASSIS, Edmund S, NGUYEN, Dao M, LEE, Sunmin

“…cDNA arrays were used to examine gene induction in CALU-6 and H460 lung cancer cells mediated by sequential 5-aza 2'-deoxycytidine (DAC)/depsipeptide FK228…”
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