Search Results - "Trepel, J.B."

Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy by Alarcon, S V, Mollapour, M, Lee, M-J, Tsutsumi, S, Lee, S, Kim, Y S, Prince, T, Apolo, A B, Giaccone, G, Xu, W, Neckers, L M, Trepel, J B

“…In 1994 the first heat shock protein 90 (Hsp90) inhibitor was identified and Hsp90 was reported to be a target for anticancer therapeutics. In the past 18…”
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Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer by Carter, C.A., Rajan, A., Keen, C., Szabo, E., Khozin, S., Thomas, A., Brzezniak, C., Guha, U., Doyle, L.A., Steinberg, S.M., Xi, L., Raffeld, M., Tomita, Y., Lee, M.J., Lee, S., Trepel, J.B., Reckamp, K.L., Koehler, S., Gitlitz, B., Salgia, R., Gandara, D., Vokes, E., Giaccone, G.

“…KRAS mutations in NSCLC are associated with a lack of response to epidermal growth factor receptor inhibitors. Selumetinib (AZD6244; ARRY-142886) is an oral…”
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Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer by Duffy, A.G., Makarova‐Rusher, O.V., Ulahannan, S.V., Rahma, O.E., Fioravanti, S., Walker, M., Abdullah, S., Raffeld, M., Anderson, V., Abi‐Jaoudeh, N., Levy, E., Wood, B.J., Lee, S., Tomita, Y., Trepel, J.B., Steinberg, S.M., Revenko, A.S., MacLeod, A.R., Peer, C.J., Figg, W.D., Greten, T.F.

“…The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal…”
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FLT3 regulates β-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells by KAJIGUCHI, T, CHUNG, E. J, LEE, S, STINE, A, KIYOI, H, NAOE, T, LEVIS, M. J, NECKERS, L, TREPEL, J. B

“…Deregulated accumulation of nuclear beta-catenin enhances transcription of beta-catenin target genes and promotes malignant transformation. Recently, acute…”
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Site-directed mutagenesis of tryptophan residues to conserved hydrophobic residues inhibits the processing of human KB cell folate receptor by Chung, K N, Paik, T H, Roberts, S, Kim, C H, Kirassova, M, Weinstein, J N, Trepel, J B, Elwood, P C

“…We are interested in identifying the ligand binding site of the human folate receptor (hFR). Previous reports have suggested a role of tryptophan(W) residues…”
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The Beta Subunit of the Interleukin-2 Receptor Mediates Interleukin-2 Induction of Anti-CD3 Redirected Cytotoxic Capability in Large Granular Lymphocytes by Colamonici, O.R., Quinones, R., Rosolen, A., J.B., Trepel, Sausville, E., Phares, J.C., Gress, R., Poplack, D., Weber, J., Schechter, G.P., Neckers, L.M.

“…The interleukin 2 (IL 2) receptor was studied in three cases of large granular lymphocyte (LGL) lymphocytosis. All cases were nonreactive with anti-Tac…”
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Significant non-S-phase DNA synthesis visualized by flow cytometry in activated and in malignant human lymphoid cells by Neckers, L M, Funkhouser, W K, Trepel, J B, Cossman, J, Gratzner, H G

“…The development of a monoclonal antibody to the deoxynucleoside bromodeoxyuridine (BrdU), combined with two parameter flow cytometry, has allowed us to examine…”
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Monoamine oxidase activity in the cardiovascular system of young and aged rats by Fuentes, J A, Trepel, J B, Neff, N H

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