Search Results - "Trepakova, Elena S"

A novel mechanism for the store-operated calcium influx pathway by Bolotina, Victoria M, Smani, Tarik, Zakharov, Sergey I, Csutora, Peter, Leno, Endri, Trepakova, Elena S

“…Activation of store-operated channels (SOCs) and capacitative calcium influx are triggered by depletion of intracellular calcium stores. However, the exact…”
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Cell culture conditions affect the ability of high content imaging assay to detect drug-induced changes in cellular parameters in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) by Balasubramanian, Bharathi, Belak, Vaclav, Verma, Isha, Prysiazhniuk, Yeva, Sannajust, Frederick, Trepakova, Elena S.

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used for drug safety and efficacy testing with various techniques, including…”
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Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern by Kirsch, Glenn E., Trepakova, Elena S., Brimecombe, Jessica C., Sidach, Serguei S., Erickson, Hope D., Kochan, Mary C., Shyjka, Lisa M., Lacerda, Antonio E., Brown, Arthur M.

“…In vitro evaluation of drug effects on hERG K + channels is a valuable tool for identifying potential proarrhythmic side effects in drug safety testing…”
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Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride by Zeng, Haoyu, Penniman, Jacob R, Kinose, Fumi, Kim, David, Trepakova, Elena S, Malik, Manish G, Dech, Spencer J, Balasubramanian, Bharathi, Salata, Joseph J

“…Blockade of the human ether-a-go-go-related gene (hERG) potassium channel, with a consequent possibility of QT prolongation and increased susceptibility to a…”
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Ca2+-independent Phospholipase A2 Is a Novel Determinant of Store-operated Ca2+ Entry by Smani, Tarik, Zakharov, Sergey I, Leno, Endri, Csutora, Peter, Trepakova, Elena S, Bolotina, Victoria M

“…Store-operated cation (SOC) channels and capacitative Ca 2+ entry (CCE) play very important role in cellular function, but the mechanism of their activation…”
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A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays by Trepakova, Elena S., Koerner, John, Pettit, Syril D., Valentin, Jean-Pierre

“…Drug-induced ventricular arrhythmia and Torsades de Pointes remain a serious public health issues in bringing safe new pharmaceuticals to the market place…”
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The hERG channel and risk of drug-acquired cardiac arrhythmia: an overview by Lagrutta, Armando A, Trepakova, Elena S, Salata, Joseph J

“…This review summarizes current knowledge of the cardiac rapidly activating delayed rectifier potassium current (I(Kr)), and its connection to drug-acquired QT…”
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Properties of a Native Cation Channel Activated by Ca2+ Store Depletion in Vascular Smooth Muscle Cells by Trepakova, Elena S., Gericke, Marion, Hirakawa, Yoji, Weisbrod, Robert M., Cohen, Richard A., Bolotina, Victoria M.

“…Depletion of intracellular Ca2+ stores activates capacitative Ca2+influx in smooth muscle cells, but the native store-operated channels that mediate such…”
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Calcium Influx Factor Directly Activates Store-operated Cation Channels in Vascular Smooth Muscle Cells by Trepakova, E S, Csutora, P, Hunton, D L, Marchase, R B, Cohen, R A, Bolotina, V M

“…Recently, we described a novel 3-pS Ca 2+ -conducting channel that is activated by BAPTA and thapsigargin-induced passive depletion of intracellular Ca 2+…”
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Flunarizine is a Highly Potent Inhibitor of Cardiac hERG Potassium Current by Trepakova, Elena S, Dech, Spencer J, Salata, Joseph J

“…Flunarizine has been widely used for the management of a variety of disorders such as peripheral vascular diseases, migraine, and epilepsy. The majority of its…”
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Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity by Trepakova, Elena S, Malik, Manish G, Imredy, John P, Penniman, Jacob R, Dech, Spencer J, Salata, Joseph J

“…A cardiac safety concern for QT prolongation and potential for pro-arrhythmia exists due to inhibition of the cardiac slowly activating delayed rectifier…”
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Safety Pharmacology of CJ-11555 by Choi, J.M. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), E-mail: jaemook@cj.net, Rowton, S (Covance Laboratories, North Yorkshire, England), Lee, S.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, I.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Park, J.E. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Noh, H.J. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of KoreaRnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, T.R. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, Y.H. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, J.W. (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Jang, J.H (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Kim, D.Y (RnD Center of Pharmaceuticals, CJ Corp., Ichon, Republic of Korea), Esmail A (Covance Laboratories, North Yorkshire, England), Trepakova Elena, S (Covance Laboratories, North Yorkshire, England)

“…Safety pharmacological properties of CJ-11555, an anti-cirrhotic agent, were investigated in experimental animals and in vitro test system. CJ-11555 had no…”
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Nitric Oxide Inhibits Capacitative Cation Influx in Human Platelets by Promoting Sarcoplasmic/Endoplasmic Reticulum Ca 2+ -ATPase–Dependent Refilling of Ca 2+ Stores by Trepakova, Elena S., Cohen, Richard A., Bolotina, Victoria M.

“…Abstract —Nitric oxide (NO) is a potent inhibitor of thrombin-induced increase in cytoplasmic free Ca 2+ concentration and aggregation in platelets, but the…”
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Nitric Oxide Inhibits Capacitative Cation Influx in Human Platelets by Promoting Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase-Dependent Refilling of Ca2+ Stores by Trepakova, Elena S, Cohen, Richard A, Bolotina, Victoria M

“…Nitric oxide (NO) is a potent inhibitor of thrombin-induced increase in cytoplasmic free Ca concentration and aggregation in platelets, but the precise…”
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Apoptosis of murine BW 5147 thymoma cells induced by cold shock by Kruman, I I, Gukovskaya, A S, Petrunyaka, V V, Beletsky, I P, Trepakova, E S

“…Exposure of thymoma BW 5147 cells to cold (0-2 degrees C) followed by rewarming at 37 degrees C (cold shock) resulted in internucleosomal DNA cleavage…”
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On the role of intracellular concentration of Ca 2+ and H + in thymocyte death after irradiation by Shaposhnikova, Vera V., Dobrovinskaya, Oksana R., Gukovskaya, Anna S., Trepakova, Elena S., Korystov, Yuri N.

“…The role of intracellular Ca 2+ and H + concentrations in radiation‐induced interphase death of rat thymocytes has been studied. In response to concanavalin A…”
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On the role of intracellular concentration of Ca2+ and H+ in thymocyte death after irradiation by Shaposhnikova, Vera V., Dobrovinskaya, Oksana R., Gukovskaya, Anna S., Trepakova, Elena S., Korystov, Yuri N.

“…The role of intracellular Ca2+ and H+ concentrations in radiation-induced interphase death of rat thymocytes has been studied. In response to concanavalin A…”
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