Search Results - "Trent Moreland, K."
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Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation
Published in Nature communications (17-11-2022)“…Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid…”
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Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites
Published in eLife (04-01-2022)“…Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA,…”
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In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90
Published in PloS one (01-04-2014)“…Otoconia are formed embryonically and are instrumental in detecting linear acceleration and gravity. Degeneration and fragmentation of otoconia in elderly…”
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Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries
Published in The Journal of pharmacology and experimental therapeutics (01-05-2007)“…Epoxyeicosatrienoic acids (EETs) have been reported to contract intralobar pulmonary arteries (PA) of the rabbit in a cyclooxygenase (COX)-dependent manner. In…”
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Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite
Published in Crystal growth & design (07-01-2015)“…We investigated the roles of three proteins associated with the formation of otoconia including fetuin A, osteopontin (OPN), and otoconin 90 (OC90). In situ…”
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