Search Results - "Trent, J O"

A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K AKT signaling by Clem, B F, Clem, A L, Yalcin, A, Goswami, U, Arumugam, S, Telang, S, Trent, J O, Chesney, J

“…Choline kinase-α expression and activity are increased in multiple human neoplasms as a result of growth factor stimulation and activation of cancer-related…”
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Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound by Sun, Daekyu, Thompson, Brian, Cathers, Brian E, Salazar, Miguel, Kerwin, Sean M, Trent, John O, Jenkins, Terence C, Neidle, Stephen, Hurley, Laurence H

“…Our laboratories have initiated a structure-based approach to discovering non-nucleoside compounds that will selectively inhibit human telomerase by targeting…”
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Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones by Perry, Philip J, Reszka, Anthony P, Wood, Alexis A, Read, Martin A, Gowan, Sharon M, Dosanjh, Harvinder S, Trent, John O, Jenkins, Terence C, Kelland, Lloyd R, Neidle, Stephen

“…Telomerase is an attractive target for the design of new anticancer drugs. We have previously described a series of 1,4- and 2,6-difunctionalized…”
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Molecular modeling of drug-DNA complexes: an update by Trent, J O

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Exploiting anthracycline scaffold for designing DNA-targeting agents by Priebe, W, Fokt, I, Przewloka, T, Chaires, J B, Portugal, J, Trent, J O

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Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding by Bates, Paula J., Kahlon, Jasbir B., Thomas, Shelia D., Trent, John O., Miller, Donald M.

“…Oligonucleotides have been extensively studied as antisense or antigene agents that can potentially modulate the expression of specific genes. These strategies…”
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Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding by Neidle, S, Kelland, L.R., Trent, J.O., Simpson, I.J., Boykin, D.W., Kumar, A., Wilson, W.D.

“…A series of alkyl derivatives of bis(phenylamidinium)furan are shown to have cytotoxic activity in several human tumour cell lines. Xray crystallographic…”
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Allosteric, Chiral-Selective Drug Binding to DNA by Qu, Xiaogang, Trent, John O., Fokt, Izabela, Priebe, Waldemar, Chaires, Jonathan B.

“…The binding interactions of (-)-daunorubicin (WP900), a newly synthesized enantiomer of the anticancer drug (+)-daunorubicin, with right- and left-handed DNA,…”
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Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides by Xu, X, Hamhouyia, F, Thomas, S D, Burke, T J, Girvan, A C, McGregor, W G, Trent, J O, Miller, D M, Bates, P J

“…The discovery of G-rich oligonucleotides (GROs) that have non-antisense antiproliferative activity against a number of cancer cell lines has been recently…”
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Rationally Designed Analogs of Tamoxifen with Improved Calmodulin Antagonism by Hardcastle, Ian R, Rowlands, Martin G, Houghton, John, Parr, Iris B, Potter, Gerard A, Jarman, Michael, Edwards, Karen J, Laughton, Charles A, Trent, John O, Neidle, Stephen

“…Computerized molecular modeling studies on the interactions of the antiestrogen tamoxifen (1) and its analogues bound to the calcium-binding protein calmodulin…”
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Mammary carcinogen-protein binding potentials: novel and biologically relevant structure-activity relationship model descriptors by Cunningham, A.R., Qamar, S., Carrasquer, C.A., Holt, P.A., Maguire, J.M., Cunningham, S.L., Trent, J.O.

“…Previously, SAR models for carcinogenesis used descriptors that are essentially chemical descriptors. Herein we report the development of models with the…”
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Targeting the Minor Groove of DNA:  Crystal Structures of Two Complexes between Furan Derivatives of Berenil and the DNA Dodecamer d(CGCGAATTCGCG)2 by Trent, John O, Clark, George R, Kumar, Arvind, Wilson, W. David, Boykin, David W, Hall, James Edwin, Tidwell, Richard R, Blagburn, Byron L, Neidle, Stephen

“…Crystal structures are reported of complexes of two novel furan derivatives of berenil with alkyl benzamidine groups bound to the DNA sequence…”
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Stability and kinetics of G-quadruplex structures by Lane, Andrew N, Chaires, J. Brad, Gray, Robert D, Trent, John O

“…In this review, we give an overview of recent literature on the structure and stability of unimolecular G-rich quadruplex structures that are relevant to drug…”
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Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding by Navenot, J M, Wang, Z X, Trent, J O, Murray, J L, Hu, Q X, DeLeeuw, L, Moore, P S, Chang, Y, Peiper, S C

“…Molecular analysis of CCR5, the cardinal coreceptor for HIV-1 infection, has implicated the N-terminal extracellular domain (N-ter) and regions vicinal to the…”
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Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization by Hu, Q, Trent, J O, Tomaras, G D, Wang, Z, Murray, J L, Conolly, S M, Navenot, J M, Barry, A P, Greenberg, M L, Peiper, S C

“…The V3 loop of the ENV glycoprotein exerts a dominant influence on the interaction of gp120 with coreceptors. Primary env genes cloned from sequential isolates…”
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Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif by Basye, J, Trent, J O, Gao, D, Ebbinghaus, S W

“…Triplex-forming oligonucleotides (TFOs) are good candidates to be used as site-specific DNA-binding agents. Two obstacles encountered with TFOs are…”
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Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides by Galande, Amit K., Trent, John O., Spatola, Arno F.

“…A recently rediscovered reaction of base‐assisted lanthionine formation has been applied to several systems of disulfide‐bridged peptides. In addition to…”
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Characterization of the active site of group B streptococcal hyaluronan lyase by Pritchard, David G., Trent, John O., Zhang, Pei, Egan, Marianne L., Baker, John R.

“…Hyaluronan lyase is secreted by most strains of the human pathogen, group B streptococcus. Site‐directed mutagenesis of the enzyme identified three amino acid…”
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Recognition of GC Base Pairs by Triplex Forming Oligonucleotides Containing Nucleosides Derived from 2-Aminopyridine by Cassidy, Sarah A., Slickers, Peter, Trent, John O., Capaldi, Daniel C., Roselt, Peter D., Reese, Colin B., Neidle, Stephen, Fox, Keith R.

“…We have attempted to alleviate the pH dependency of triplex recognition of guanine by using intermolecular triplexes containing…”
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Sequence-dependent crossed helix packing in the crystal structure of a B-DNA decamer yields a detailed model for the Holliday junction by Wood, A A, Nunn, C M, Trent, J O, Neidle, S

“…The structure of the B-DNA decamer d(CGCAATTGCG)2 has been determined by X-ray diffraction analysis to a resolution of 2.3 A and an R-factor of 17.7%. The…”
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