Search Results - "Trenor, B."

Mechanistic investigation of extracellular K+ accumulation during acute myocardial ischemia: a simulation study by Rodríguez, B, Ferrero, Jr, J M, Trénor, B

“…In this study, we have used computer simulations to study the mechanisms of extracellular K+ accumulation during acute ischemia. A modified version of the…”
Get more information

Multiscale computational analysis of the bioelectric consequences of myocardial ischaemia and infarction by Ferrero, Jose M, Trenor, Beatriz, Romero, Lucia

“…Ischaemic heart disease is considered as the single most frequent cause of death, provoking more than 7 000 000 deaths every year worldwide. A high percentage…”
Get full text

Human and rabbit inter-species comparison of ionic mechanisms of arrhythmic risk: A simulation study by Romero, L, Carbonell, B, Trenor, B, Rodriguez, B, Saiz, J, Ferrero, J M

“…Experimental studies of pro-arrhythmic mechanisms are scarcely performed in humans due to the limited availability of human cardiomyocytes. Subsequently,…”
Get full text

Effects of late sodium current enhancement during LQT-related arrhythmias. A simulation study by Cardona, K, Trenor, B, Rajamani, S, Romero, L, Ferrero, J M, Saiz, J

“…Long QT syndrome is a repolarization disorder characterized by marked prolongation of QT interval. A clear consequence of long QT syndrome is the occurrence of…”
Get full text

In silico ischaemia-induced reentry at the Purkinje-ventricle interface by Ramirez, Esteban, Saiz, Javier, Romero, Lucia, Ferrero, Jose M, Trenor, Beatriz

“…This computational modelling work illustrates the influence of hyperkalaemia and electrical uncoupling induced by defined ischaemia on action potential (AP)…”
Get full text

Role of the late sodium current in arrhythmias related to low repolarization reserve by Cardona, K, Trenor, B, Romero, L, Ferrero, J M, Saiz, J

“…The prolongation of action potential duration (APD) is usually related to conditions of low repolarization reserve and leads to long QT syndrome. In these…”
Get full text

Combined effects of acquired LQT syndrome by dofetilide and reduced repolarization reserve on human ventricular action potential: A simulation study by Gonzalez, R, Romero, L, Gomis-Tena, J, Trenor, B, Ferrero, J M, Saiz, J

“…The aim of this study was to investigate interactions between acquired long QT syndrome by dofetilide and reduced repolarization reserve in simulated human…”
Get full text

Potentiation of dofetilide LQT-related effects by late sodium current enhancement: A simulation study by Cardona, K, Saiz, J, Romero, L, Carbonell, B, Ferrero, J M, Trenor, B

“…Torsades de pointes (TdP) is a life-threatening ventricular tachycardia associated to reduction of the rapid delayed rectifier potassium current (I Kr ) and…”
Get full text

A sensitivity study of the safety factor for conduction in the myocardium by Romero, L., Trenor, B., Ferrero, J.M., Saiz, J.

“…The safety factor (SF) is an indicator of the safeness of electrical conduction in the myocardium. In the present work, we have studied the sensitivity of the…”
Get full text

Effects of acute ischemia and its components on the safety factor of conduction: a simulation study by Romero, L., Ferrero, J.M., Trenor, B., Saiz, J.

“…In this work, we have studied the changes that acute myocardial ischemia exerts in our formulation of the safety factor of conduction (SF m ) which consists on…”
Get full text

Pinacidil-induced block of action potential propagation in ischaemic tissue: a simulation study by Trenor, B., Ferrero, J. M.

“…During ischaemia, ATP-sensitive potassium current (I(K(ATP)))is activated in ventricular myocytes. The action potential (AP) duration becomes subsequently…”
Get full text

Pinacidil modifies the vulnerability to reentry during regional myocardial ischemia in a dose dependent manner: a simulation study by Trenor, B., Ferrero, J.M., Montilla, F.

“…Potassium channel openers, such as pinacidil, are known to increase ATP-sensitive potassium current. Its activation changes markedly action potential…”
Get full text

Patterns of electrical activation in an inhomogeneous ischemic sheet of myocardial tissue: a simulation study by Trenor, B., Ferrero, J.M., Montilla, F.

“…Acute regional myocardial ischemia can lead to re-entrant activity under certain circumstances. Electrophysiological inhomogeneities within the tissue…”
Get full text

Effects of pinacidil on refractoriness in acutely ischemic tissue: insights from experiments and simulations by Trenor, B., Ferrero, J.M., Saiz, J., Ferrero, A., Chorro, J., Monserrat, M., Hernandez, V., Molto, G.

“…A controversy exits regarding the arrhythmogenic effect of potassium channel openers, such as pinacidil, during acute myocardial ischemia. In order to throw…”
Get full text

Simulation of figure-of-eight reentry during acute inhomogeneous myocardial ischemia: role of ATP-sensitive potassium current by Ferrero, J.M., Trenor, B., Saiz, J., Rodriguez, B.

“…Figure-of-eight reentry is an abnormal pattern of excitation which is commonly found in hearts subject to acute myocardial regional ischemia. This type of…”
Get full text

Effects of potassium channel openers nicorandil and pinacidil on electrical activity of cardiac cells and cardiac tissues: a simulation study by Trenor, B., Ferrero, J.M.

“…Potassium channel openers (KCOs) have been reported to activate ATP-sensitive potassium channels (K/sub (ATP)/) in cardiac muscle. The activation of this…”
Get full text

Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study by Trénor, Beatriz, Ferrero, Jr, José M, Rodríguez, Blanca, Montilla, Fulgencio

“…Many experimental studies have pointed out the controversy involving the arrhythmogenic effects of potassium channel openers (KCOs) in ischemia. KCOs activate…”
Get full text

A Grid Computing-Based Approach for the Acceleration of Simulations in Cardiology by Alonso, Jose M., Ferrero, Jose M., Hernandez, Vicente, Molto, German, Saiz, Javier, Trenor, Beatriz

“…This paper combines high-performance computing and grid computing technologies to accelerate multiple executions of a biomedical application that simulates the…”
Get full text

Role of the ATP-sensitive potassium current in extracellular potassium accumulation during myocardial ischemia: a simulation study by Rodriguez, B., Ferrero, J.M., Trenor, B., Ferrero, J.M., Thakor, N.V.

“…During acute myocardial ischemia, accumulation of K/sup +/ in the extracellular medium plays a major role in the development of reentrant arrhythmias. The…”
Get full text

Simulation study of the effect of pinacidil on ATP-sensitive potassium current and action potential duration in myocardial tissue by Trenor, B., Ferrero, J.M., Rodriguez, B., Saiz, J., Ferrero, J.M., Thakor, N.K.

“…Metabolic impairment and potassium channel openers, such as pinacidil, activate the ATP-sensitive potassium current [I/sub K(ATP)/]. This effect leads to a…”
Get full text