Search Results - "Trends in molecular medicine"

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives by Sun, Jiumeng, He, Wan-Ting, Wang, Lifang, Lai, Alexander, Ji, Xiang, Zhai, Xiaofeng, Li, Gairu, Suchard, Marc A., Tian, Jin, Zhou, Jiyong, Veit, Michael, Su, Shuo

“…The recent outbreak of COVID-19 in Wuhan turned into a public health emergency of international concern. With no antiviral drugs nor vaccines, and the presence…”
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Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies by Claesson-Welsh, Lena, Dejana, Elisabetta, McDonald, Donald M.

“…Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis. Dysregulated endothelial…”
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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging by D’Amico, Davide, Andreux, Pénélope A., Valdés, Pamela, Singh, Anurag, Rinsch, Chris, Auwerx, Johan

“…Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods…”
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Mitophagy and Neuroprotection by Lou, Guofeng, Palikaras, Konstantinos, Lautrup, Sofie, Scheibye-Knudsen, Morten, Tavernarakis, Nektarios, Fang, Evandro F.

“…Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the…”
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Therapeutic Targeting of Long Non-Coding RNAs in Cancer by Arun, Gayatri, Diermeier, Sarah D., Spector, David L.

“…Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific…”
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Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology by Voet, Sofie, Prinz, Marco, van Loo, Geert

“…Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but…”
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Ferroptosis in the tumor microenvironment: perspectives for immunotherapy by Xu, Huanji, Ye, Di, Ren, Meiling, Zhang, Hongying, Bi, Feng

“…Targeting ferroptosis, which provokes lipid peroxidation in cancer cells, presents potentially new avenues for anticancer therapy. Recent studies have begun to…”
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Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease by Bourgonje, Arno R., Feelisch, Martin, Faber, Klaas Nico, Pasch, Andreas, Dijkstra, Gerard, van Goor, Harry

“…Inflammatory bowel disease (IBD) is associated with the production of reactive species that target cysteine redox switches in proteins, thereby affecting gene…”
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Disease Modeling in Stem Cell-Derived 3D Organoid Systems by Dutta, Devanjali, Heo, Inha, Clevers, Hans

“…Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can recapitulate the in vivo architecture, functionality and genetic…”
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Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus by Reeves, Benjamin C., Karimy, Jason K., Kundishora, Adam J., Mestre, Humberto, Cerci, H. Mert, Matouk, Charles, Alper, Seth L., Lundgaard, Iben, Nedergaard, Maiken, Kahle, Kristopher T.

“…Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain…”
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Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines by Moll, Guido, Ankrum, James A., Kamhieh-Milz, Julian, Bieback, Karen, Ringdén, Olle, Volk, Hans-Dieter, Geissler, Sven, Reinke, Petra

“…Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials…”
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Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response by Linares-Fernández, Sergio, Lacroix, Céline, Exposito, Jean-Yves, Verrier, Bernard

“…mRNA vaccine platforms present numerous advantages, such as versatility, rapid production, and induction of cellular and humoral responses. Moreover, mRNAs…”
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Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis by Trougakos, Ioannis P., Terpos, Evangelos, Alexopoulos, Harry, Politou, Marianna, Paraskevis, Dimitrios, Scorilas, Andreas, Kastritis, Efstathios, Andreakos, Evangelos, Dimopoulos, Meletios A.

“…Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19) pandemic, and mRNA vaccines are central to the ongoing vaccination campaign…”
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Abandoning the Notion of Non-Small Cell Lung Cancer by Relli, Valeria, Trerotola, Marco, Guerra, Emanuela, Alberti, Saverio

“…Non-small cell lung cancers (NSCLCs) represent 85% of lung tumors. NSCLCs encompass multiple cancer types, such as adenocarcinomas (LUADs), squamous cell…”
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Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA by Luo, Huiyan, Wei, Wei, Ye, Ziyi, Zheng, Jiabo, Xu, Rui-hua

“…Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a promising noninvasive diagnostic approach in oncology. Abnormal…”
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PRMTs and Arginine Methylation: Cancer’s Best-Kept Secret? by Jarrold, James, Davies, Clare C.

“…Post-translational modification (PTM) of proteins is vital for increasing proteome diversity and maintaining cellular homeostasis. If the writing, reading, and…”
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Antibiotic-Induced Changes in the Intestinal Microbiota and Disease by Becattini, Simone, Taur, Ying, Pamer, Eric G

“…The gut microbiota is a key player in many physiological and pathological processes occurring in humans. Recent investigations suggest that the efficacy of…”
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MicroRNAs in cancer: biomarkers, functions and therapy by Hayes, Josie, Peruzzi, Pier Paolo, Lawler, Sean

“…Highlights • MicroRNAs have emerged as key regulators of cancer cell biology. • MicroRNA signatures can define tumor types, susceptibility, prognosis, and…”
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G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies by Carvalho, Josué, Mergny, Jean-Louis, Salgado, Gilmar F., Queiroz, João A., Cruz, Carla

“…The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical…”
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Manufacturing Exosomes: A Promising Therapeutic Platform by Colao, Ivano Luigi, Corteling, Randolph, Bracewell, Daniel, Wall, Ivan

“…Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical…”
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