Search Results - "Trends in genetics"

Navigating the DNA methylation landscape of cancer by Nishiyama, Atsuya, Nakanishi, Makoto

“…DNA methylation is a chemical modification that defines cell type and lineage through the control of gene expression and genome stability. Disruption of DNA…”
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Emerging concepts of miRNA therapeutics: from cells to clinic by Diener, Caroline, Keller, Andreas, Meese, Eckart

“…MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a single miRNA can direct entire cellular pathways via interacting with…”
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DNA methylation: a historical perspective by Mattei, Alexandra L., Bailly, Nina, Meissner, Alexander

“…In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the…”
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The Third Revolution in Sequencing Technology by van Dijk, Erwin L., Jaszczyszyn, Yan, Naquin, Delphine, Thermes, Claude

“…Forty years ago the advent of Sanger sequencing was revolutionary as it allowed complete genome sequences to be deciphered for the first time. A second…”
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Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies by Centore, Richard C., Sandoval, Gabriel J., Soares, Luis Miguel Mendes, Kadoch, Cigall, Chan, Ho Man

“…Small molecule-based targeting of chromatin regulatory factors has emerged as a promising therapeutic strategy in recent years. The development and ongoing…”
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Opening the Black Box: Interpretable Machine Learning for Geneticists by Azodi, Christina B., Tang, Jiliang, Shiu, Shin-Han

“…Because of its ability to find complex patterns in high dimensional and heterogeneous data, machine learning (ML) has emerged as a critical tool for making…”
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Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression by Sun, Qinyu, Hao, Qinyu, Prasanth, Kannanganattu V.

“…A significant portion of the human genome encodes genes that transcribe long nonprotein-coding RNAs (lncRNAs). A large number of lncRNAs localize in the…”
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How genomics can help biodiversity conservation by Theissinger, Kathrin, Fernandes, Carlos, Formenti, Giulio, Bista, Iliana, Bleidorn, Christoph, Bombarely, Aureliano, Crottini, Angelica, Gallo, Guido R., Godoy, José A., Jentoft, Sissel, Mouton, Alice, Oomen, Rebekah A., Paez, Sadye, Palsbøll, Per J., Pampoulie, Christophe, Ruiz-López, María J., Theofanopoulou, Constantina, de Vries, Jan, Waldvogel, Ann-Marie, Zhang, Guojie, Jarvis, Erich D., Ciofi, Claudio, Mazzoni, Camila J., Höglund, Jacob, Aghayan, Sargis A., Alioto, Tyler S., Almudi, Isabel, Alvarez, Nadir, Alves, Paulo C., Amorim do Rosario, Isabel R., Antunes, Agostinho, Arribas, Paula, Baldrian, Petr, Bertorelle, Giorgio, Böhne, Astrid, Bonisoli-Alquati, Andrea, Boštjančić, Ljudevit L., Boussau, Bastien, Buzan, Elena, Campos, Paula F., Carreras, Carlos, Castro, L. FIlipe C., Chueca, Luis J., Conti, Elena, Croll, Daniel, Dennis, Alice B., Dimitrov, Dimitar, Favre, Adrien, Fedrigo, Olivier D., Fernández, Rosa, Ficetola, Gentile Francesco, Gabaldón, Toni, Agius, Dolores R., Gilbert, M. Thomas P., Grebenc, Tine, Guschanski, Katerina, Guyot, Romain, Hausdorf, Bernhard, Hawlitschek, Oliver, Heintzman, Peter D., Heinze, Berthold, Hiller, Michael, Husemann, Martin, Kloch, Agnieszka, Kusche, Henrik, Layton, Kara K.S., Lerat, Emmanuelle, Manousaki, Tereza, Marques-Bonet, Tomas, Matschiner, Michael, Mc Cartney, Ann M., Meiri, Shai, Melo-Ferreira, José, Mengual, Ximo, Monaghan, Michael T., Montagna, Matteo, Mysłajek, Robert W., Novo, Marta, Ozretić, Petar, Pârvulescu, Lucian, Pascual, Marta, Paulo, Octávio S., Pavlek, Martina, Pesole, Graziano, Primmer, Craig R., Riesgo, Ana, Rubolini, Diego, Salvi, Daniele, Seehausen, Ole, Seidel, Matthias, Studer, Bruno, Theodoridis, Spyros, Thines, Marco, Vasemägi, Anti, Vernes, Sonja C., Vernesi, Cristiano, Vieites, David R., Wörheide, Gert, Wurm, Yannick, Zammit, Gabrielle

“…Genomics provides effective tools to characterize biodiversity, but the full implementation of genomic techniques in practical conservation is still limited…”
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Circular RNA Expression: Its Potential Regulation and Function by Salzman, Julia

“…In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express…”
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Advances in the Evolutionary Understanding of MHC Polymorphism by Radwan, Jacek, Babik, Wiesław, Kaufman, Jim, Lenz, Tobias L., Winternitz, Jamie

“…Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on…”
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The Landscape of long noncoding RNA classification by St. Laurent, Georges, Wahlestedt, Claes, Kapranov, Philipp

“…Highlights • ncRNAs constitute the majority of transcriptional output of the human genome. • Lack of functional knowledge of most of ncRNAs has led to…”
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DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing by Xue, Chaoyou, Greene, Eric C.

“…Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based genome editing technologies take advantage of…”
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Ten years of next-generation sequencing technology by van Dijk, Erwin L, Auger, Hélène, Jaszczyszyn, Yan, Thermes, Claude

“…Highlights • Impressive advances in NGS have enabled an immense diversity of novel applications. • The barrier of the $1000 genome has recently been broken. •…”
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Lateral Thinking: How Histone Modifications Regulate Gene Expression by Lawrence, Moyra, Daujat, Sylvain, Schneider, Robert

“…The DNA of each cell is wrapped around histone octamers, forming so-called ‘nucleosomal core particles’. These histone proteins have tails that project from…”
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Classical and noncanonical functions of miRNAs in cancers by Dragomir, Mihnea P., Knutsen, Erik, Calin, George A.

“…Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the…”
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Where Are the Disease-Associated eQTLs? by Umans, Benjamin D., Battle, Alexis, Gilad, Yoav

“…Most disease-associated variants, although located in putatively regulatory regions, do not have detectable effects on gene expression. One explanation could…”
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Supervised Machine Learning for Population Genetics: A New Paradigm by Schrider, Daniel R., Kern, Andrew D.

“…As population genomic datasets grow in size, researchers are faced with the daunting task of making sense of a flood of information. To keep pace with this…”
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Single-Cell Multiomics: Multiple Measurements from Single Cells by Macaulay, Iain C, Ponting, Chris P, Voet, Thierry

“…Single-cell sequencing provides information that is not confounded by genotypic or phenotypic heterogeneity of bulk samples. Sequencing of one molecular type…”
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Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation by Kan, Ryan L., Chen, Jianjun, Sallam, Tamer

“…Epigenetic modifications occur on genomic DNA and histones to influence gene expression. More recently, the discovery that mRNA undergoes similar chemical…”
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To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases by Supek, Fran, Lehner, Ben, Lindeboom, Rik G.H.

“…The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the…”
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