Search Results - "Trends in cell biology"

EMT Transition States during Tumor Progression and Metastasis by Pastushenko, Ievgenia, Blanpain, Cédric

“…Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal features. In cancer, EMT is associated with tumor…”
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Emerging Mechanisms and Disease Relevance of Ferroptosis by Stockwell, Brent R., Jiang, Xuejun, Gu, Wei

“…Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating…”
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EMT, MET, Plasticity, and Tumor Metastasis by Bakir, Basil, Chiarella, Anna M., Pitarresi, Jason R., Rustgi, Anil K.

“…Cancer cell identity and plasticity are required in transition states, such as epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition…”
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Hallmarks of Cellular Senescence by Hernandez-Segura, Alejandra, Nehme, Jamil, Demaria, Marco

“…Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to…”
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Protein Phase Separation: A New Phase in Cell Biology by Boeynaems, Steven, Alberti, Simon, Fawzi, Nicolas L., Mittag, Tanja, Polymenidou, Magdalini, Rousseau, Frederic, Schymkowitz, Joost, Shorter, James, Wolozin, Benjamin, Van Den Bosch, Ludo, Tompa, Peter, Fuxreiter, Monika

“…Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu…”
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Extracellular vesicles and nanoparticles: emerging complexities by Jeppesen, Dennis K., Zhang, Qin, Franklin, Jeffrey L., Coffey, Robert J.

“…Research from the past few years has overturned our understanding of the field of extracellular vesicles (EVs) and nanoparticles (NPs) by demonstrating a much…”
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The Complex Interplay between Antioxidants and ROS in Cancer by Harris, Isaac S., DeNicola, Gina M.

“…Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular signaling, differentiation, and survival. In this review, we discuss the…”
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Tight Junction Structure and Function Revisited by Otani, Tetsuhisa, Furuse, Mikio

“…Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of…”
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Lipid Rafts: Controversies Resolved, Mysteries Remain by Levental, Ilya, Levental, Kandice R., Heberle, Frederick A.

“…The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize biological membranes into domains of distinct structures,…”
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Gasdermins: Effectors of Pyroptosis by Kovacs, Stephen B, Miao, Edward A

“…Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of…”
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The Roles of CD8+ T Cell Subsets in Antitumor Immunity by St. Paul, Michael, Ohashi, Pamela S.

“…Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that produce interferon-(IFN) γ. However, recent findings have…”
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Extracellular Vesicles: Unique Intercellular Delivery Vehicles by Maas, Sybren L.N, Breakefield, Xandra O, Weaver, Alissa M

“…Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers with complex cargoes including proteins, lipids, and nucleic acids…”
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Cell cycle on the crossroad of tumorigenesis and cancer therapy by Liu, Jing, Peng, Yunhua, Wei, Wenyi

“…Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying tumorigenesis, making regulators of the cell cycle machinery rational…”
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Ferroptosis: Death by Lipid Peroxidation by Yang, Wan Seok, Stockwell, Brent R

“…Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation…”
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Metabolic Interactions in the Tumor Microenvironment by Lyssiotis, Costas A., Kimmelman, Alec C.

“…Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a unique physiology. Within this network, the malignant cells encounter…”
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Principles and Properties of Stress Granules by Protter, David S.W, Parker, Roy

“…Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that form from mRNAs stalled in translation initiation. Stress granules…”
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Lipid Metabolism in Regulation of Macrophage Functions by Yan, Jiawei, Horng, Tiffany

“…Macrophages are cells of the innate immune system that regulate the maintenance of tissue homeostasis, host defense during pathogen infection, and tissue…”
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Cytoskeletal Crosstalk in Cell Migration by Seetharaman, Shailaja, Etienne-Manneville, Sandrine

“…Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly comprises the actin microfilaments, microtubules, and intermediate…”
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PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells by Noordermeer, Sylvie M., van Attikum, Haico

“…Poly-(ADP)-ribose polymerase (PARP) inhibition is synthetic lethal with deficiency for homologous recombination (HR), a pathway essential for DNA double-strand…”
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Long Noncoding RNA in Cancer: Wiring Signaling Circuitry by Lin, Chunru, Yang, Liuqing

“…Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained…”
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