Search Results - "Trendelenburg, George"

Molecular Regulation of Cell Fate in Cerebral Ischemia: Role of the Inflammasome and Connected Pathways by Trendelenburg, George

“…Analogous to Toll-like receptors, NOD-like receptors represent a class of pattern recognition receptors, which are cytosolic and constitute part of different…”
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Acute neurodegeneration and the inflammasome: central processor for danger signals and the inflammatory response? by Trendelenburg, George

“…Activation of the inflammatory response is a crucial event in the adverse outcome of cerebral ischemia, which is promoted by proinflammatory cytokines such as…”
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Defective cholesterol clearance limits remyelination in the aged central nervous system by Cantuti-Castelvetri, Ludovico, Fitzner, Dirk, Bosch-Queralt, Mar, Weil, Marie-Theres, Su, Minhui, Sen, Paromita, Ruhwedel, Torben, Mitkovski, Miso, Trendelenburg, George, Lütjohann, Dieter, Möbius, Wiebke, Simons, Mikael

“…Age-associated decline in regeneration capacity limits the restoration of nervous system functionality after injury. In a model for demyelination, we found…”
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Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning by Trendelenburg, George, Dirnagl, Ulrich

“…Following focal cerebral ischemia (“stroke”) a complex and dynamic interaction of vascular cells, glial cells, and neurons determines the extent of the ensuing…”
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The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia by Witzenrath, Martin, Pache, Florence, Lorenz, Daniel, Koppe, Uwe, Gutbier, Birgitt, Tabeling, Christoph, Reppe, Katrin, Meixenberger, Karolin, Dorhoi, Anca, Ma, Jiangtao, Holmes, Ashleigh, Trendelenburg, George, Heimesaat, Markus M, Bereswill, Stefan, van der Linden, Mark, Tschopp, Jürg, Mitchell, Timothy J, Suttorp, Norbert, Opitz, Bastian

“…Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the…”
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Assessment of the Therapeutic Potential of Metallothionein-II Application in Focal Cerebral Ischemia In Vitro and In Vivo by Eidizadeh, Abass, Khajehalichalehshtari, Manuel, Freyer, Dorette, Trendelenburg, George

“…Metallothionein-II (MT-II) is an ubiquitously expressed small-molecular-weight protein and highly induced in various species and tissues upon stress,…”
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Evaluation of the Therapeutic Potential of Anti-TLR4-Antibody MTS510 in Experimental Stroke and Significance of Different Routes of Application by Andresen, Lena, Theodorou, Konstantina, Grünewald, Sarah, Czech-Zechmeister, Bozena, Könnecke, Birte, Lühder, Fred, Trendelenburg, George

“…Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition…”
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Focusing on the protective effects of metallothionein-Ⅰ/Ⅱ in cerebral ischemia by Eidizadeh, Abass, Trendelenburg, George

“…Ischemic stroke is a leading cause of death and has a remarkable social and economical impact, which rises with the increasing age of the industrial…”
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CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia by Harhausen, Denise, Prinz, Vincent, Ziegler, Gina, Gertz, Karen, Endres, Matthias, Lehrach, Hans, Gasque, Philippe, Botto, Marina, Stahel, Philip F, Dirnagl, Ulrich, Nietfeld, Wilfried, Trendelenburg, George

“…The stem-cell marker CD93 (AA4.1/C1qRp) has been described as a potential complement C1q-receptor. Its exact molecular function, however, remains unknown. By…”
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Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice by Harhausen, Denise, Khojasteh, Uldus, Stahel, Philip F, Morgan, B Paul, Nietfeld, Wilfried, Dirnagl, Ulrich, Trendelenburg, George

“…The complement system is a crucial mediator of inflammation and cell lysis after cerebral ischemia. However, there is little information about the exact…”
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HEV-Associated Neuralgic Amyotrophy: A Multicentric Case Series by Bannasch, Johannes H., Berger, Benjamin, Schwartkop, Claus-Peter, Berning, Marco, Goetze, Oliver, Panning, Marcus, Fritz-Weltin, Miriam, Trendelenburg, George, Gelderblom, Mathias, Lütgehetmann, Marc, Stute, Fridrike, Horvatits, Thomas, Dirks, Meike, Antoni, Christoph, Behrendt, Patrick, Pischke, Sven

“…Background: Neuralgic amyotrophy (NA) has been described as a possible extrahepatic manifestation of hepatitis E virus (HEV) infection. Usually, HEV-associated…”
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Mannose-binding lectin—the forgotten molecule? by Osthoff, Michael, Trendelenburg, George, Eisen, Damon P, Trendelenburg, Marten

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Serial Analysis of Gene Expression Identifies Metallothionein-II as Major Neuroprotective Gene in Mouse Focal Cerebral Ischemia by Trendelenburg, George, Prass, Konstantin, Priller, Josef, Kapinya, Krisztian, Polley, Andreas, Muselmann, Claudia, Ruscher, Karsten, Kannbley, Ute, Schmitt, Armin O, Castell, Stefanie, Wiegand, Frank, Meisel, Andreas, Rosenthal, Andre, Dirnagl, Ulrich

“…We applied serial analysis of gene expression (SAGE) to study differentially expressed genes in mouse brain 14 hr after the induction of focal cerebral…”
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Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons by Ruscher, Karsten, Isaev, Nikolaj, Trendelenburg, George, Weih, Markus, Iurato, Linda, Meisel, Andreas, Dirnagl, Ulrich

“…Hypoxia-inducible factor 1 (HIF-1) is a posttranscriptionally regulated transcription factor, controlling several hypoxia-inducible genes. Here we show a rapid…”
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Induction of tolerance in rat cortical neurons: hypoxic preconditioning by Bruer, Ulrike, Weih, Markus K, Isaev, Nikolaj K, Meisel, Andreas, Ruscher, Karsten, Bergk, Alexandra, Trendelenburg, George, Wiegand, Frank, Victorov, Ilya V, Dirnagl, Ulrich

“…Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study we modeled preconditioning…”
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COVID‐19 Vaccine‐Associated Cerebral Venous Thrombosis in Germany by Schulz, Jörg B., Berlit, Peter, Diener, Hans‐Christoph, Gerloff, Christian, Greinacher, Andreas, Klein, Christine, Petzold, Gabor C., Piccininni, Marco, Poli, Sven, Röhrig, Rainer, Steinmetz, Helmuth, Thiele, Thomas, Kurth, Tobias, Alonso, Angelika, Bartsch, Thorsten, Baumsteiger, Christoph, Bode, Felix, Cangür, Hakan, Daffertshofer, Michael, Dafotakis, Manuel, Dieterich, Marianne, Fabian, Friederike, Fousse, Mathias, Godau, Jana, Grond, Martin, Günther, Albrecht, Gutschalk, Alexander, Hagemann, Georg, Hartmann, Corinna, Hilker‐Roggendorf, Rüdiger, Höglinger, Günter, Ikenberg, Benno, Ismail, Fatme Seval, Jesse, Sarah, Kallmünzer, Bernd, Kern, Rolf, Klietz, Martin, Knauß, Samuel, Knier, Benjamin, Limmroth, Volker, Mengel, Annerose, Meyne, Johannes, Morgenthaler, Martin, Müller, Matthias, Nagel, Simon, Niels, Ralf Dittrich, Onur, Oezguer A., Pelz, Johann, Plenge, Johannes, Poli, Sven, Roth, Christian, Röther, Joachim, Saß, Christian, Schönenberger, Silvia, Schubert, Roger, Simon, Ole, Agaplesion, Ina Specht, Sperfeld, Anne, Spreer, Annette, Steinbrecher, Andreas, Steiner, Jochen, Stetefeld, Henning, Trendelenburg, George, Vatankhah, Nils Bijan, Wahl, Christoph Michael, Wartenberg, Katja, Witt, Karsten, Wittstock, Matthias, Wolf, Björn, Wolf, Joachim, Zimmermann, Julian

“…Objective We aimed to estimate the incidence of cerebral sinus and venous thrombosis (CVT) within 1 month from first dose administration and the frequency of…”
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Improved protocol for SAGE tag-to-gene allocation by Kannbley, Ute, Kapinya, Krisztian, Dirnagl, Ulrich, Trendelenburg, George

“…Serial analysis of gene expression (SAGE) is a powerful method for large-scale analysis of gene expression patterns. SAGE yields digital information on…”
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Blocking TLR2 in vivo Protects against Accumulation of Inflammatory Cells and Neuronal Injury in Experimental Stroke by Ziegler, Gina, Freyer, Dorette, Harhausen, Denise, Khojasteh, Uldus, Nietfeld, Wilfried, Trendelenburg, George

“…Reduced infarct volume in TLR2-knockout mice compared with C57Bl/6 wild-type mice has recently been shown in experimental stroke and confirmed in this study…”
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Knockout of Silent Information Regulator 2 (SIRT2) Preserves Neurological Function after Experimental Stroke in Mice by Krey, Lea, Lühder, Fred, Kusch, Kathrin, Czech-Zechmeister, Bozena, Könnecke, Birte, Outeiro, Tiago Fleming, Trendelenburg, George

“…Sirtuin-2 (Sirt2) is a member of the NAD+-dependent protein deacetylase family. Various members of the sirtuin class have been found to be involved in…”
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Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival by Langenkamp, Elise, Zhang, Lei, Lugano, Roberta, Huang, Hua, Elhassan, Tamador Elsir Abu, Georganaki, Maria, Bazzar, Wesam, Lööf, Johan, Trendelenburg, George, Essand, Magnus, Pontén, Fredrik, Smits, Anja, Dimberg, Anna

“…Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in…”
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