Search Results - "Trencsényi, Gyorgy"
-
1
Stable and Inert Mn(II)-Based and pH-Responsive Contrast Agents
Published in Journal of the American Chemical Society (29-01-2020)“…Smart/intelligent contrast agent candidates for MRI based on Mn(II) ion are rare, as it usually forms labile complexes with polyaminocarboxylate-type ligands…”
Get full text
Journal Article -
2
Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results
Published in International journal of molecular sciences (01-01-2024)“…Targeted alpha-particle therapy using radionuclides with alpha emission is a rapidly developing area in modern cancer treatment. To selectively deliver…”
Get full text
Journal Article -
3
Scandium-44: Diagnostic Feasibility in Tumor-Related Angiogenesis
Published in International journal of molecular sciences (01-04-2023)“…Angiogenesis-related cell-surface molecules, including integrins, aminopeptidase N, vascular endothelial growth factor, and gastrin-releasing peptide receptor…”
Get full text
Journal Article -
4
Insights into recent preclinical studies on labelled cyclodextrin-based imaging probes: Towards a novel oncological era
Published in International journal of pharmaceutics (10-06-2023)“…[Display omitted] As malignancies remain one of the major health concerns worldwide, increasing focus has been centered around the application of cyclodextrins…”
Get full text
Journal Article -
5
Subrenal Capsule Assay - SRCA: The Promising Re-Emergence of a Long-Forgotten Method in Preclinical Nuclear Medical Cancer Diagnostics
Published in Journal of Cancer (2023)“…Since metastases are responsible for the majority of cancer-related death, in-depth understanding of metastatisation may provide an opportunity for the…”
Get full text
Journal Article -
6
Diagnosis of Melanoma with 61Cu-Labeled PET Tracer
Published in Journal of medicinal chemistry (13-06-2024)“…Until the recent years, substances containing radioactive 61Cu were strongly considered as potential positron-emitting radiopharmaceuticals for use in positron…”
Get full text
Journal Article -
7
NGR-Based Radiopharmaceuticals for Angiogenesis Imaging: A Preclinical Review
Published in International journal of molecular sciences (01-08-2023)“…Angiogenesis plays a crucial role in tumour progression and metastatic spread; therefore, the development of specific vectors targeting angiogenesis has…”
Get full text
Journal Article -
8
Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2018)“…Our study aimed at finding a mechanistic relationship between the gut microbiome and breast cancer. Breast cancer cells are not in direct contact with these…”
Get full text
Journal Article -
9
Mn(II)-Based MRI Contrast Agent Candidate for Vascular Imaging
Published in Journal of medicinal chemistry (11-06-2020)“…Toxicity concerns related to Gd(III)-based magnetic resonance imaging (MRI) agents prompted an intensive research toward their replacement by complexes of…”
Get full text
Journal Article -
10
[52Mn]Mn‑BPPA-Trastuzumab: A Promising HER2‑Specific PET Radiotracer
Published in Journal of medicinal chemistry (23-05-2024)“…This study aimed to develop a novel radiotracer using trastuzumab and the long-lived [52Mn]Mn isotope for HER2-targeted therapy selection and monitoring. A new…”
Get full text
Journal Article -
11
A generic gas chromatography method for determination of residual solvents in PET radiopharmaceuticals
Published in Journal of pharmaceutical and biomedical analysis (05-01-2022)“…•A single GC method was proposed for analysis of volatile compounds in PET tracers.•Quantitation of solvents could be performed at ethanol concentration of up…”
Get full text
Journal Article -
12
Implant Imaging: Perspectives of Nuclear Imaging in Implant, Biomaterial, and Stem Cell Research
Published in Bioengineering (Basel) (25-04-2023)“…Until now, very few efforts have been made to specifically trace, monitor, and visualize implantations, artificial organs, and bioengineered scaffolds for…”
Get full text
Journal Article -
13
Caffeine-Induced Acute and Delayed Responses in Cerebral Metabolism of Control and Schizophrenia-like Wisket Rats
Published in International journal of molecular sciences (01-08-2022)“…Recently, morphological impairments have been detected in the brain of a triple-hit rat schizophrenia model (Wisket), and delayed depressive effects of…”
Get full text
Journal Article -
14
Boosting Bismuth(III) Complexation for Targeted α‐Therapy (TAT) Applications with the Mesocyclic Chelating Agent AAZTA
Published in Angewandte Chemie International Edition (24-10-2022)“…Targeted α therapy (TAT) is a promising tool in the therapy of cancer. The radionuclide 213BiIII shows favourable physical properties for this application, but…”
Get full text
Journal Article -
15
AAZTA‐Like Ligands Bearing Phenolate Arms as Efficient Chelators for 68Ga Labelling in vitro and in vivo
Published in Chemistry : a European journal (13-04-2023)“…The introduction of a phenolate pendant arm in place of an acetate on AAZTA‐ and DATA‐like ligands resulted in hepta‐ and hexadentate chelators able to form…”
Get full text
Journal Article -
16
PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [68Ga]Ga-NODAGA-AMBA and [44Sc]Sc-NODAGA-AMBA
Published in International journal of molecular sciences (02-09-2022)“…Gastrin-releasing peptide receptors (GRPR) are overexpressed in prostate cancer (PCa). Since bombesin analogue aminobenzoic-acid (AMBA) binds to GRPR with high…”
Get full text
Journal Article -
17
In Vivo Preclinical Assessment of β-Amyloid-Affine [ 11 C]C-PIB Accumulation in Aluminium-Induced Alzheimer's Disease-Resembling Hypercholesterinaemic Rat Model
Published in International journal of molecular sciences (12-11-2022)“…Aluminum (Al) excess and hypercholesterinaemia are established risks of Alzheimer's disease (AD). The aim of this study was to establish an AD-resembling…”
Get full text
Journal Article -
18
In Vivo Assessments of Mesoblastic Nephroma (Ne/De) and Myelomonoblastic Leukaemia (My1/De) Tumour Development in Hypercholesterolemia Rat Models
Published in International journal of molecular sciences (27-10-2022)“…Given the rising prevalence of lipid metabolic disorders and malignant diseases, we aimed to establish an in vivo hypercholesterinaemic tumour-bearing rat…”
Get full text
Journal Article -
19
Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of 68Ga-, 205/206Bi-, and 177Lu-Labeled NAPamide-Based Radiopharmaceuticals
Published in Pharmaceuticals (Basel, Switzerland) (11-09-2023)“…Although radiolabeled alpha-melanocyte stimulating hormone-analogue NAPamide derivatives are valuable melanoma-specific diagnostic probes, their rapid…”
Get full text
Journal Article -
20
Evaluation of the therapeutic efficacy of 213Bi-labelled DOTA-conjugated alpha-melanocyte stimulating hormone peptide analogues in melanocortin-1 receptor positive preclinical melanoma model
Published in International journal of pharmaceutics (25-09-2023)“…[Display omitted] Melanocortin-1 receptor (MC1-R) targeting alpha-melanocyte stimulating hormone-analogue (α-MSH) biomolecules labelled with α-emitting…”
Get full text
Journal Article