Search Results - "Tremolanti, Chiara"
-
1
Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation
Published in International journal of molecular sciences (10-09-2019)“…A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about…”
Get full text
Journal Article -
2
Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles
Published in Nanomaterials (Basel, Switzerland) (23-04-2019)“…Therapeutic proteins and enzymes are a group of interesting candidates for the treatment of numerous diseases, but they often require a carrier to avoid…”
Get full text
Journal Article -
3
De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein
Published in International journal of molecular sciences (18-03-2021)“…Neuroactive steroids are potent modulators of microglial functions and are capable of counteracting their excessive reactivity. This action has mainly been…”
Get full text
Journal Article -
4
Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis
Published in Molecular neurobiology (01-03-2022)“…Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells,…”
Get full text
Journal Article -
5
A Public Dataset of 24-h Multi-Levels Psycho-Physiological Responses in Young Healthy Adults
Published in Data (Basel) (01-12-2020)“…Wearable devices now make it possible to record large quantities of physiological data, which can be used to obtain a clearer view of a person’s health status…”
Get full text
Journal Article -
6
The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein
Published in Biochimica et biophysica acta. Molecular basis of disease (01-08-2023)“…Neurodegenerative disease-associated microglia commonly exhibit harmful cholesterol accumulation that impairs their ability to resolve the neuroinflammatory…”
Get more information
Journal Article -
7
Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis
Published in Biochimica et biophysica acta. Molecular basis of disease (01-06-2024)“…Mature oligodendrocytes (OLs) arise from oligodendrocyte precursor cells that, in case of demyelination, are recruited at the lesion site to remyelinate the…”
Get full text
Journal Article -
8
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
Published in European journal of medicinal chemistry (05-10-2021)“…Long-term survivors of glioblastoma multiforme (GBM) are at high risk of developing second primary neoplasms, including leukemia. For these patients, the use…”
Get full text
Journal Article