Search Results - "Tremethick, David J."

Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells by Cole, Lauren, Kurscheid, Sebastian, Nekrasov, Maxim, Domaschenz, Renae, Vera, Daniel L., Dennis, Jonathan H., Tremethick, David J.

“…Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity. The histone variant H2A.Z has been shown to contribute to this…”
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The Histone Variant H2A.Z Is a Master Regulator of the Epithelial-Mesenchymal Transition by Domaschenz, Renae, Kurscheid, Sebastian, Nekrasov, Maxim, Han, Shuyi, Tremethick, David J.

“…Epithelial-mesenchymal transition (EMT) is a profound example of cell plasticity that is crucial for embryonic development and cancer. Although it has long…”
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A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B by Soboleva, Tatiana A, Parker, Brian J, Nekrasov, Maxim, Hart-Smith, Gene, Tay, Ying Jin, Tng, Wei-Quan, Wilkins, Marc, Ryan, Daniel, Tremethick, David J

“…The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B…”
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The Role of the Histone Variant H2A.Z in Metazoan Development by Dijkwel, Yasmin, Tremethick, David J.

“…During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to…”
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Gene editing of the multi-copy H2A.B gene and its importance for fertility by Anuar, Nur Diana, Kurscheid, Sebastian, Field, Matt, Zhang, Lei, Rebar, Edward, Gregory, Philip, Buchou, Thierry, Bowles, Josephine, Koopman, Peter, Tremethick, David J, Soboleva, Tatiana A

“…Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene…”
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Histone variants at the transcription start-site by Soboleva, Tatiana A, Nekrasov, Maxim, Ryan, Daniel P, Tremethick, David J

“…Highlights • The transcription start-site (TSS) is not histone-free and is associated with specific histone variants in higher eukaryotes. • The TSS of an…”
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Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics by Nekrasov, Maxim, Amrichova, Jana, Parker, Brian J, Soboleva, Tatiana A, Jack, Cameron, Williams, Rohan, Huttley, Gavin A, Tremethick, David J

“…Histone H2A.Z-containing nucleosomes flank the transcription start sites (TSSs) of active mammalian genes. A new study reveals that histone H2A.Z at the TSS is…”
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H2A.Z contributes to the unique 3D structure of the centromere by Greaves, Ian K, Rangasamy, Danny, Ridgway, Patricia, Tremethick, David J

“…Mammalian centromere function depends upon a specialized chromatin organization where distinct domains of CENP-A and dimethyl K4 histone H3, forming centric…”
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Short Histone H2A Variants: Small in Stature but not in Function by Jiang, Xuanzhao, Soboleva, Tatiana A, Tremethick, David J

“…The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to…”
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New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? by Luger, Karolin, Dechassa, Mekonnen L., Tremethick, David J.

“…Key Points Nucleosomes exist in an assortment of structural states that differ from the various crystal structures. The equilibrium between the nucleosomal…”
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The X and Y Chromosomes Assemble into H2A.Z, Containing Facultative Heterochromatin, following Meiosis by Greaves, Ian K., Rangasamy, Danny, Devoy, Michael, Marshall Graves, Jennifer A., Tremethick, David J.

“…ERRATUM ( vol. 26 , p. 7343 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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A New Fluorescence Resonance Energy Transfer Approach Demonstrates That the Histone Variant H2AZ Stabilizes the Histone Octamer within the Nucleosome by Park, Young-Jun, Dyer, Pamela N, Tremethick, David J, Luger, Karolin

“…Nucleosomes are highly dynamic macromolecular complexes that are assembled and disassembled in a modular fashion. One important way in which this dynamic…”
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Crystal structure of a nucleosome core particle containing the variant histone H2A.Z by Luger, Karolin, Suto, Robert K, Clarkson, Michael J, Tremethick, David J

“…Activation of transcription within chromatin has been correlated with the incorporation of the essential histone variant H2A.Z into nucleosomes. H2A.Z and…”
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Dynamic Histone Variant Exchange Accompanies Gene Induction in T Cells by Sutcliffe, Elissa L., Parish, Ian A., He, Yi Qing, Juelich, Torsten, Tierney, M. Louise, Rangasamy, Danny, Milburn, Peter J., Parish, Christopher R., Tremethick, David J., Rao, Sudha

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA by Bao, Yunhe, Konesky, Kasey, Park, Young-Jun, Rosu, Simona, Dyer, Pamela N, Rangasamy, Danny, Tremethick, David J, Laybourn, Paul J, Luger, Karolin

“…H2A.Bbd is an unusual histone variant whose sequence is only 48% conserved compared to major H2A. The major sequence differences are in the docking domain that…”
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Histone-mediated Transduction as an Efficient Means for Gene Delivery by Wagstaff, Kylie M, Glover, Dominic J, Tremethick, David J, Jans, David A

“…Gene delivery into the nucleus of eukaryotic cells is inefficient, largely because of the significant barriers within the target cell of the plasma membrane…”
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Histone variant H2A.Z is required for early mammalian development by Faast, Renate, Thonglairoam, Varaporn, Schulz, Thomas C, Beall, Jacquie, Wells, Julian R.E, Taylor, Helen, Matthaei, Klaus, Rathjen, Peter D, Tremethick, David J, Lyons, Ian

“…Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression. This requires transcription of a precise subset…”
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Higher-Order Structures of Chromatin: The Elusive 30 nm Fiber by Tremethick, David J.

“…Despite progress in understanding chromatin function, the structure of the 30 nm chromatin fiber has remained elusive. However, with the recent crystal…”
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Multifunctional histone variants in genome function by Wong, Lee H, Tremethick, David J

“…Histones are integral components of eukaryotic chromatin that have a pivotal role in the organization and function of the genome. The dynamic regulation of…”
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Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness by Yang, Ming, Rangasamy, Danny, Matthaei, Klaus I, Frew, Ailsa J, Zimmmermann, Nives, Mahalingam, Suresh, Webb, Dianne C, Tremethick, David J, Thompson, Philip J, Hogan, Simon P, Rothenberg, Marc E, Cowden, William B, Foster, Paul S

“…Increased arginase I activity is associated with allergic disorders such as asthma. How arginase I contributes to and is regulated by allergic inflammatory…”
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