Search Results - "Trembleau, Laurent"

A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif by Wang, Shan, Lin, Sixing, Fang, Qing, Gyampoh, Roland, Lu, Zhou, Gao, Yingli, Clarke, David J., Wu, Kewen, Trembleau, Laurent, Yu, Yi, Kyeremeh, Kwaku, Milne, Bruce F., Tabudravu, Jioji, Deng, Hai

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are structurally complex natural products with diverse bioactivities. Here we report…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain by Koehnke, Jesko, Bent, Andrew, Houssen, Wael E, Zollman, David, Morawitz, Falk, Shirran, Sally, Vendome, Jeremie, Nneoyiegbe, Ada F, Trembleau, Laurent, Botting, Catherine H, Smith, Margaret C M, Jaspars, Marcel, Naismith, James H

“…The subtilisin-like domain of PatG can catalyze the macrocyclization of linear peptide. The crystal structure of the PatG macrocyclase domain, along with…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.

“…A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both…”
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Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors by Al-Wahaibi, Lamya H, Mostafa, Yaser A, Abdelrahman, Mostafa H, El-Bahrawy, Ali H, Trembleau, Laurent, Youssif, Bahaa G. M

“…The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to…”
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Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A by Liu, Yating, Su, Li, Fang, Qing, Tabudravu, Jioji, Yang, Xiaohui, Rickaby, Kirstie, Trembleau, Laurent, Kyeremeh, Kwaku, Deng, Zixin, Deng, Hai, Yu, Yi

“…Tricyclic carbazole is an important scaffold in many naturally occurring metabolites, as well as valuable building blocks. Here we report the reconstitution of…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G M

“…A small set of indole-based derivatives, and - , was designed and synthesized. Compounds - demonstrated promising antiproliferative activity, with GI values…”
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A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway by Parajuli, Anirudra, Kwak, Daniel H., Dalponte, Luca, Leikoski, Niina, Galica, Tomas, Umeobika, Ugochukwu, Trembleau, Laurent, Bent, Andrew, Sivonen, Kaarina, Wahlsten, Matti, Wang, Hao, Rizzi, Ermanno, De Bellis, Gianluca, Naismith, James, Jaspars, Marcel, Liu, Xinyu, Houssen, Wael, Fewer, David Peter

“…Cyanobactins are a rapidly growing family of linear and cyclic peptides produced by cyanobacteria. Kawaguchipeptins A and B, two macrocyclic undecapeptides…”
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Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide by Idress, Mohannad, Milne, Bruce F, Thompson, Gary S, Trembleau, Laurent, Jaspars, Marcel, Houssen, Wael E

“…As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by…”
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A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models by Mielnik, Catharine A., Sugamori, Kim S., Finlay, David B., Thorpe, Hayley H. A., Schapira, Matthieu, Sivananthan, Nirunthan, Li, Chun Kit, Lam, Vincent M., Harrington, Sean, Abdelrahman, Mostafa H., Trembleau, Laurent A., McIntyre Burnham, W., Khokhar, Jibran Y., Salahpour, Ali, Ramsey, Amy J., Glass, Michelle, Greig, Iain R., Ross, Ruth A.

“…Abstract The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs…”
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Helical Conformation of Alkanes in a Hydrophobic Cavitand by Trembleau, Laurent, Rebek, Julius

“…Alkanes adopt extended conformations in solution that minimize steric interactions and maximize surface area. Folding can reduce the amount of hydrophobic…”
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Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity by Al-Wahaibi, Lamya H, Abou-Zied, Hesham A, Abdelrahman, Mostafa H, Morcoss, Martha M, Trembleau, Laurent, Youssif, Bahaa G M, Bräse, Stefan

“…The present study details the design, synthesis, and bio-evaluation of indoles as dual inhibitors of aromatase and inducible nitric oxide synthase (iNOS)with…”
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Helical Folding of Alkanes in a Self-Assembled, Cylindrical Capsule by Scarso, Alessandro, Trembleau, Laurent, Rebek, Julius

“…The reversible encapsulation of a series of normal alkane guests in a cylindrical host was studied by NMR methods. For small hydrocarbons such as n-pentane or…”
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Synthesis and characterisation of biologically compatible TiO2 nanoparticles by Cheyne, Richard W, Smith, Tim AD, Trembleau, Laurent, Mclaughlin, Abbie C

“…We describe for the first time the synthesis of biocompatible TiO 2 nanoparticles containing a functional NH 2 group which are easily dispersible in water. The…”
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Multigram-Scale Synthesis of Short Peptides via a Simplified Repetitive Solution-Phase Procedure by Meneses, Célia, Nicoll, Sarah L, Trembleau, Laurent

“…A rapid repetitive solution-phase synthesis of peptides is described. The procedure involves coupling of amino acids and peptide acids, instead of the usual…”
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Kinetically Stable Complexes in Water:  The Role of Hydration and Hydrophobicity by Biros, Shannon M, Ullrich, Elke C, Hof, Fraser, Trembleau, Laurent, Rebek, Julius

“…We describe here the synthesis and characterization of a molecular receptor that forms kinetically and thermodynamically stable host−guest complexes in water…”
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Galmic, a Nonpeptide Galanin Receptor Agonist, Affects Behaviors in Seizure, Pain, and Forced-Swim Tests by Bartfai, Tamas, Lu, Xiaoying, Badie-Mahdavi, Hedieh, Barr, Alasdair M., Mazarati, Andrey, Hua, Xiao-Ying, Yaksh, Tony, Haberhauer, Gebhard, Ceide, Susana Conde, Trembleau, Laurent, Somogyi, Laszlo, Kröck, Lenz, Rebek, Julius

“…The pharmacological exploitation of the galanin receptors as drug targets for treatment of epilepsy, depression, and pain has been hampered by the lack of…”
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A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms by Schaefer, Katja, Dambuza, Ivy M, Dall'Angelo, Sergio, Yuecel, Raif, Jaspars, Marcel, Trembleau, Laurent, Zanda, Matteo, Brown, Gordon D, Netea, Mihai G, Gow, Neil A R

“…The discovery of liquid water at several locations in the solar system raises the possibility that microbial life may have evolved outside Earth and as such…”
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Different N—H...π interactions in two indole derivatives by Kerr, Jamie R., Trembleau, Laurent, Storey, John M. D., Wardell, James L., Harrison, William T. A.

“…We describe the syntheses and crystal structures of two indole derivatives, namely 6-isopropyl-3-(2-nitro-1-phenylethyl)-1 H -indole, C 19 H 20 N 2 O 2 , (I),…”
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Weak interactions in the crystal structures of two indole derivatives by Kerr, Jamie R., Trembleau, Laurent, Storey, John M. D., Wardell, James L., Harrison, William T. A.

“…We describe the syntheses and crystal structures of two indole derivatives, namely a second monoclinic polymorph of ethyl 5-chloro-1 H -indole-2-carboxylate C…”
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