Search Results - "Tremblay, Roch"
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Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis
Published in Nature communications (30-11-2021)“…Eukaryotic cells have evolved highly orchestrated protein catabolic machineries responsible for the timely and selective disposal of proteins and organelles,…”
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Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome
Published in JCI insight (23-05-2022)“…The eukaryotic CDC45/MCM2-7/GINS (CMG) helicase unwinds the DNA double helix during DNA replication. The GINS subcomplex is required for helicase activity and…”
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Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins
Published in Molecular and cellular biology (2023)“…In , newly synthesized histones H3 are acetylated on lysine 56 (H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind…”
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