Search Results - "Tremblay, Michel L"

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics by Hardy, Serge, Zolotarov, Yevgen, Coleman, Jacob, Roitman, Simon, Khursheed, Hira, Aubry, Isabelle, Uetani, Noriko, Tremblay, Michel L

“…Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2, PTP4A3, respectively) control intracellular magnesium levels by…”
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Modulation of Leptin Resistance by Protein Tyrosine Phosphatases by St-Pierre, Julie, Tremblay, Michel L.

“…Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain…”
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Physiological and oncogenic roles of the PRL phosphatases by Hardy, Serge, Kostantin, Elie, Hatzihristidis, Teri, Zolotarov, Yevgen, Uetani, Noriko, Tremblay, Michel L.

“…The human Phosphatase of Regenerative Liver (PRL) family comprises three members (PRL‐1, ‐2, ‐3; gene name PTP4A1, PTP4A2, PTP4A3) that are highly expressed in…”
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TC-PTP and PTP1B: Regulating JAK–STAT signaling, controlling lymphoid malignancies by Pike, Kelly A., Tremblay, Michel L.

“…•The JAK–STAT pathway is frequently mutated in leukemia and lymphoma.•STATs play a critical role in establishing a cell’s transcriptional program.•PTPs PTP1B…”
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Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia by Penafuerte, Claudia A, Gagnon, Bruno, Sirois, Jacinthe, Murphy, Jessica, MacDonald, Neil, Tremblay, Michel L

“…Background: Cachexia is a metabolic disorder characterised by muscle wasting, diminished response to anti-cancer treatments and poor quality of life. Our…”
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Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism by Hardy, Serge, Kostantin, Elie, Wang, Shan Jin, Hristova, Tzvetena, Galicia-Vázquez, Gabriela, Baranov, Pavel V., Pelletier, Jerry, Tremblay, Michel L.

“…Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association…”
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Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol by Cencic, Regina, Carrier, Marilyn, Galicia-Vázquez, Gabriela, Bordeleau, Marie-Eve, Sukarieh, Rami, Bourdeau, Annie, Brem, Brigitte, Teodoro, Jose G, Greger, Harald, Tremblay, Michel L, Porco, Jr, John A, Pelletier, Jerry

“…Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation…”
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Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease by Pike, Kelly A, Tremblay, Michel L

“…Protein tyrosine phosphatases (PTPs) play a critical role in co-ordinating the signaling networks that maintain lymphocyte homeostasis and direct lymphocyte…”
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In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis by Stuible, Matthew, Tremblay, Michel L

“…Receptor tyrosine kinases (RTKs) control the cellular response to a range of stimuli by binding extracellular factors and transmitting appropriate signals to…”
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ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer by Deblois, Geneviève, Smith, Harvey W., Tam, Ingrid S., Gravel, Simon-Pierre, Caron, Maxime, Savage, Paul, Labbé, David P., Bégin, Louis R., Tremblay, Michel L., Park, Morag, Bourque, Guillaume, St-Pierre, Julie, Muller, William J., Giguère, Vincent

“…Despite the initial benefits of treating HER2-amplified breast cancer patients with the tyrosine kinase inhibitor lapatinib, resistance inevitably develops…”
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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice by Wiede, Florian, Shields, Benjamin J, Kyparissoudis, Sock Hui Chew Konstantinos, van Vliet, Catherine, Galic, Sandra, Tremblay, Michel L, Russell, Sarah M, Godfrey, Dale I, Tiganis, Tony

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Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation by Kim, Dae Joon, Tremblay, Michel L, Digiovanni, John

“…Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na(3)VO(4) desensitized keratinocytes to UVB-induced…”
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Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity by Svensson, Mattias Nd, Doody, Karen M, Schmiedel, Benjamin J, Bhattacharyya, Sourya, Panwar, Bharat, Wiede, Florian, Yang, Shen, Santelli, Eugenio, Wu, Dennis J, Sacchetti, Cristiano, Gujar, Ravindra, Seumois, Gregory, Kiosses, William B, Aubry, Isabelle, Kim, Gisen, Mydel, Piotr, Sakaguchi, Shimon, Kronenberg, Mitchell, Tiganis, Tony, Tremblay, Michel L, Ay, Ferhat, Vijayanand, Pandurangan, Bottini, Nunzio

“…Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA)…”
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Osteopontin is a therapeutic target that drives breast cancer recurrence by Gu, Yu, Taifour, Tarek, Bui, Tung, Zuo, Dongmei, Pacis, Alain, Poirier, Alexandre, Attalla, Sherif, Fortier, Anne-Marie, Sanguin-Gendreau, Virginie, Pan, Tien-Chi, Papavasiliou, Vasilios, Lin, Nancy U., Hughes, Melissa E., Smith, Kalie, Park, Morag, Tremblay, Michel L., Chodosh, Lewis A., Jeselsohn, Rinath, Muller, William J.

“…Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the…”
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PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease by Poirier, Alexandre, Picard, Cynthia, Labonté, Anne, Aubry, Isabelle, Auld, Daniel, Zetterberg, Henrik, Blennow, Kaj, Tremblay, Michel L., Poirier, Judes

“…We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly available…”
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Cancer anorexia‐cachexia syndrome is characterized by more than one inflammatory pathway by Gagnon, Bruno, Murphy, Jessica, Simonyan, David, Penafuerte, Claudia A., Sirois, Jacinthe, Chasen, Martin, Tremblay, Michel L.

“…Background The interdependence of cytokines and appetite‐modifying hormones implicated in cancer anorexia‐cachexia syndrome (CACS) remains unclear. This study…”
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Brief exposure of neuronal cells to levels of SCFAs observed in human systemic circulation impair lipid metabolism resulting in apoptosis by Fillier, Tiffany A., Shah, Shrushti, Doody, Karen M., Pham, Thu H., Aubry, Isabelle, Tremblay, Michel L., Cheema, Sukhinder K., Blundell, Jacqueline, Thomas, Raymond H.

“…Communication between gut microbiota and the brain is an enigma. Alterations in the gut microbial community affects enteric metabolite levels, such as short…”
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Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2 -induced mammary tumorigenesis and protects from lung metastasis by Kennedy, Brian P, Julien, Sofi G, Read, Michelle, Dubé, Nadia, Muller, William J, Han, Yongxin, Penney, Janice, Tremblay, Michel L, Paquet, Marilene

“…We investigated the role of protein tyrosine phosphatase 1B (PTP1B) in mammary tumorigenesis using both genetic and pharmacological approaches. It has been…”
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A sulfated carbohydrate epitope inhibits axon regeneration after injury by Brown, Joshua M., Xia, Jiang, Zhuang, BinQuan, Cho, Kin-Sang, Rogers, Claude J., Gama, Cristal I., Rawat, Manish, Tully, Sarah E., Uetani, Noriko, Mason, Daniel E., Tremblay, Michel L., Peters, Eric C., Habuchi, Osami, Chen, Dong F., Hsieh-Wilson, Linda C.

“…Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of…”
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Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells by Bunin, Anna, Sisirak, Vanja, Ghosh, Hiyaa S., Grajkowska, Lucja T., Hou, Z. Esther, Miron, Michelle, Yang, Cliff, Ceribelli, Michele, Uetani, Noriko, Chaperot, Laurence, Plumas, Joel, Hendriks, Wiljan, Tremblay, Michel L., Häcker, Hans, Staudt, Louis M., Green, Peter H., Bhagat, Govind, Reizis, Boris

“…Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by…”
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