Search Results - "Tremblay, Benjamin J. M."
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Interplay between coding and non-coding regulation drives the Arabidopsis seed-to-seedling transition
Published in Nature communications (26-02-2024)“…Translation of seed stored mRNAs is essential to trigger germination. However, when RNAPII re-engages RNA synthesis during the seed-to-seedling transition has…”
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Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains
Published in Nature communications (06-09-2023)“…The analysis of microbial genomes from human archaeological samples offers a historic snapshot of ancient pathogens and provides insights into the origins of…”
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Enhancing diversity analysis by repeatedly rarefying next generation sequencing data describing microbial communities
Published in Scientific reports (16-11-2021)“…Amplicon sequencing has revolutionized our ability to study DNA collected from environmental samples by providing a rapid and sensitive technique for microbial…”
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Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
Published in The European respiratory journal (01-09-2020)“…In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV, the…”
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PhyloCorrelate: inferring bacterial gene–gene functional associations through large-scale phylogenetic profiling
Published in Bioinformatics (Oxford, England) (09-04-2021)“…Abstract Motivation Statistical detection of co-occurring genes across genomes, known as ‘phylogenetic profiling’, is a powerful bioinformatic technique for…”
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Mechanisms of epigenetic regulation of transcription by lncRNAs in plants
Published in IUBMB life (01-05-2023)“…Long noncoding RNAs (lncRNAs) are an ubiquitous feature of eukaryotic genomes and in recent decades have been shown to be highly abundant and varied. Many…”
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Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus
Published in Journal of general virology (01-12-2020)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been…”
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Endogenous CRISPR-Cas Systems in Group I Clostridium botulinum and Clostridium sporogenes Do Not Directly Target the Botulinum Neurotoxin Gene Cluster
Published in Frontiers in microbiology (09-02-2022)“…Most strains of proteolytic group I (G1 ) and some strains of possess genes encoding botulinum neurotoxin (BoNT), a potent neuroparalytic agent. Within G1 ,…”
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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses
Published in iScience (21-05-2021)“…Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit…”
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ABCF1 Regulates dsDNA-induced Immune Responses in Human Airway Epithelial Cells
Published in Frontiers in cellular and infection microbiology (16-09-2020)“…The airway epithelium represents a critical component of the human lung that helps orchestrate defenses against respiratory tract viral infections, which are…”
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Expression of endocannabinoid system components in human airway epithelial cells: impact of sex and chronic respiratory disease status
Published in ERJ open research (01-10-2020)“…Cannabis smoking is the dominant route of delivery, with the airway epithelium functioning as the site of first contact. The endocannabinoid system is…”
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Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B
Published in PLoS pathogens (28-12-2020)“…Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two…”
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Quaqc: Efficient and quick ATAC-seq quality control and filtering
Published in Bioinformatics (Oxford, England) (01-11-2024)“…quaqc allows for ATAC-seq-specific quality control and read filtering of NGS data with minimal processing time and extremely low memory overhead. An efficient…”
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