Search Results - "Treistman, Steven N"

Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol by Pietrzykowski, Andrzej Z., Friesen, Ryan M., Martin, Gilles E., Puig, Sylvie I., Nowak, Cheryl L., Wynne, Patricia M., Siegelmann, Hava T., Treistman, Steven N.

“…Tolerance represents a critical component of addiction. The large-conductance calcium- and voltage-activated potassium channel (BK) is a well-established…”
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Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol by Martin, Gilles E, Hendrickson, Linzy M, Penta, Krista L, Friesen, Ryan M, Pietrzykowski, Andrzej Z, Tapper, Andrew R, Treistman, Steven N

“…Tolerance, described as the loss of drug effectiveness over time, is an important component of addiction. The degree of acute behavioral tolerance to alcohol…”
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Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids by Yuan, Chunbo, Chen, Maohui, Covey, Douglas F, Johnston, Linda J, Treistman, Steven N

“…In the search to uncover ethanol's molecular mechanisms, the calcium and voltage activated, large conductance potassium channel (BK) has emerged as an…”
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Lipids modulate the increase of BK channel calcium sensitivity by the β1 subunit by Yuan, Chunbo, Velázquez-Marrero, Cristina, Bernardo, Alexandra, Treistman, Steven N

“…Co-expression of the auxiliary β1 subunit with the pore forming α subunit of BK dramatically alters apparent calcium sensitivity. Investigation of the…”
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BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice by Kreifeldt, Max, Le, David, Treistman, Steven N, Koob, George F, Contet, Candice

“…Large conductance calcium-activated potassium (BK) channels play a key role in the control of neuronal activity. Ethanol is a potent activator of BK channel…”
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Regulation of the Gating of BKCa Channel by Lipid Bilayer Thickness by Yuan, Chunbo, O'Connell, Robert J., Jacob, Robert F., Mason, R. Preston, Treistman, Steven N.

“…Transmembrane segments of ion channels tend to match the hydrophobic thickness of lipid bilayers to minimize mismatch energy and to maintain their proper…”
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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers by Crowley, John J, Treistman, Steven N, Dopico, Alejandro M

“…The activity of large conductance, Ca2+-sensitive K+ (BKCa) channels, known to control neuronal excitability, is increased by ethanol (EtOH) exposure…”
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Acute Alcohol Tolerance Is Intrinsic to the BKCa Protein, but Is Modulated by the Lipid Environment by Yuan, Chunbo, O'Connell, Robert J., Wilson, Andrew, Pietrzykowski, Andrzej Z., Treistman, Steven N.

“…Ethanol tolerance, in which exposure leads to reduced sensitivity, is an important component of alcohol abuse and addiction. The molecular mechanisms…”
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Requirement of JIP scaffold proteins for NMDA-mediated signal transduction by Kennedy, Norman J, Martin, Gilles, Ehrhardt, Anka G, Cavanagh-Kyros, Julie, Kuan, Chia-Yi, Rakic, Pasko, Flavell, Richard A, Treistman, Steven N, Davis, Roger J

“…JIP scaffold proteins are implicated in the regulation of protein kinase signal transduction pathways. To test the physiological role of these scaffold…”
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Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels by Crowley, John J, Treistman, Steven N, Dopico, Alejandro M

“…Large conductance Ca2+ -activated K+ (BK) channel activity and its potentiation by ethanol are both critically modulated by bilayer phosphatidylserine (PS), a…”
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BK Channels: mediators and models for alcohol tolerance by Treistman, Steven N, Martin, Gilles E

“…Enhanced acute tolerance predicts alcohol abuse. We describe work on the role of the calcium- and voltage-gated BK channel in alcohol tolerance, highlighting…”
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Confounding effects of volatile anesthesia on CBV assessment in rodent forebrain following ethanol challenge by Luo, Feng, Li, Zhixin, Treistman, Steven N., Kim, Young Ro, King, Jean A., Fox, Gerard B., Ferris, Craig F.

“…Purpose To compare and contrast the pattern and characteristics of the cerebral blood volume (CBV) response to ethanol (EtOH) in rats under awake and…”
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Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells by Martin, Gilles, O'Connell, Robert J., Pietrzykowski, Andrzej Z., Treistman, Steven N., Ethier, Michael F., Madison, J. Mark

“…Large-conductance, calcium-activated potassium (BK Ca ) channels are regulated by voltage and near-membrane calcium concentrations and are determinants of…”
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Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings by Dopico, Alejandro M., Widmer, Hélène, Wang, Gang, Lemos, José R., Treistman, Steven N.

“…Large conductance, Ca 2+ -activated K + (BK) channels were identified in freshly dissociated rat supraoptic neurones using patch clamp techniques. The single…”
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Integrated channel plasticity contributes to alcohol tolerance in neurohypophysial terminals by Knott, Thomas K, Dopico, Alejandro M, Dayanithi, Govindan, Lemos, José, Treistman, Steven N

“…Short-term ethanol challenge results in the reduction of peptide hormone release from the rat neurohypophysis. However, rats that have been maintained on an…”
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Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling by Velázquez-Marrero, Cristina, Burgos, Alexandra, García, José O, Palacio, Stephanie, Marrero, Héctor G, Bernardo, Alexandra, Pérez-Laspiur, Juliana, Rivera-Oliver, Marla, Seale, Garrett, Treistman, Steven N

“…It has been suggested that drug tolerance represents a form of learning and memory, but this has not been experimentally established at the molecular level. We…”
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Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons by Palacio, Stephanie, Velázquez-Marrero, Cristina, Marrero, Héctor G., Seale, Garrett E., Yudowski, Guillermo A., Treistman, Steven N.

“…Background The large conductance Ca2+‐ and voltage‐activated K+ channel (BK) is an important player in molecular and behavioral alcohol tolerance. Trafficking…”
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Ethanol Effect on BK Channels is Modulated by Magnesium by Marrero, Héctor G., Treistman, Steven N., Lemos, José R.

“…Background Alcoholics have been reported to have reduced levels of magnesium in both their extracellular and intracellular compartments. Calcium‐dependent…”
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μ-Opioid inhibition of Ca2+ currents and secretion in isolated terminals of the neurohypophysis occurs via ryanodine-sensitive Ca2+ stores by Velázquez-Marrero, Cristina, Ortiz-Miranda, Sonia, Marrero, Héctor G, Custer, Edward E, Treistman, Steven N, Lemos, José R

“…μ-Opioid agonists have no effect on calcium currents (I(Ca)) in neurohypophysial terminals when recorded using the classic whole-cell patch-clamp…”
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The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear by Velázquez-Marrero, Cristina, Wynne, Patricia, Bernardo, Alexandra, Palacio, Stephanie, Martin, Gilles, Treistman, Steven N

“…The neuronal calcium- and voltage-activated BK potassium channel is modulated by ethanol, and plays a role in behavioral tolerance in vertebrates and…”
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