Allelic Loss of Chromosomes 16q and 10q in Human Prostate Cancer

Allelic Loss of Chromosomes 16q and 10q in Human Prostate Cancer

Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 87; no. 22; pp. 8751 - 8755
Main Authors: Carter, Bob S., Ewing, Charles M., Ward, W. Steven, Treiger, Brent F., Aalders, Tilly W., Schalken, Jack A., Epstein, Jonathan I., Isaacs, William B.
Format: Journal Article
Language:English
Published: Washington, DC National Academy of Sciences of the United States of America 01-11-1990
National Acad Sciences
Subjects:
550400 - Genetics
Alleles
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
Blotting, Southern
BODY
Cancer
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
Chromosome Deletion
Chromosome Mapping
CHROMOSOMES
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 16
DISEASES
DNA
DNA HYBRIDIZATION
DNA Probes
GENE REGULATION
Genes, Tumor Suppressor
Genetic loci
GLANDS
Gynecology. Andrology. Obstetrics
HETEROCHROMOSOMES
HUMAN CHROMOSOME 16
HUMAN CHROMOSOMES
Humans
HYBRIDIZATION
Loss of heterozygosity
Male
Male genital diseases
MALE GENITALS
Medical genetics
Medical sciences
MUTATIONS
NEOPLASMS
ORGANS
PATHOGENESIS
PATIENTS
Polymorphism, Restriction Fragment Length
PROSTATE
Prostate cancer
Prostatic Neoplasms - genetics
Tumor suppressor genes
Tumors
Human
Heterozygozity
C10-Chromosome
E16»-Chromosome
Tumor
Suppressor gene
Prostate
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Summary:Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes. We have examined allelic loss in the most common tumor in men, prostate cancer. Twenty-eight prostate cancer specimens have been examined for loss of heterozygosity at 11 different chromosomal arms including 3p, 7q, 9q, 10p, 10q, 11p, 13q, 16p, 16q, 17p, and 18q. Fifty-four percent (13/24) of clinically localized tumors and 4 of 4 metastic tumors showed loss of heterozygosity on at least one chromosome. Chromosomes 16q and 10q exhibited the highest frequency of loss of heterozygosity with 30% of tumors showing loss at these chromosomes. These data demonstrate that allelic loss is a common event in prostate cancer and suggest that chromosomes 16q and 10q may contain the sites of tumor suppressor genes important in the pathogenesis of human prostate cancer.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.87.22.8751