Search Results - "Treiber, Daniel K."

Comprehensive analysis of kinase inhibitor selectivity by Davis, Mindy I, Hunt, Jeremy P, Herrgard, Sanna, Ciceri, Pietro, Wodicka, Lisa M, Pallares, Gabriel, Hocker, Michael, Treiber, Daniel K, Zarrinkar, Patrick P

“…Davis et al . extend their previous efforts to use inhibitor-kinase interactions to understand kinase inhibitor selectivity by profiling the binding of 72…”
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Progress towards a public chemogenomic set for protein kinases and a call for contributions by Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M

“…Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human…”
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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology by Ciceri, Pietro, Müller, Susanne, O'Mahony, Alison, Fedorov, Oleg, Filippakopoulos, Panagis, Hunt, Jeremy P, Lasater, Elisabeth A, Pallares, Gabriel, Picaud, Sarah, Wells, Christopher, Martin, Sarah, Wodicka, Lisa M, Shah, Neil P, Treiber, Daniel K, Knapp, Stefan

“…Kinases are a widely targeted enzyme class in cancer chemotherapy. Several clinically used kinase inhibitors also inhibit bromodomains, epigenetic ‘readers’ of…”
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A quantitative analysis of kinase inhibitor selectivity by Zarrinkar, Patrick P, Karaman, Mazen W, Herrgard, Sanna, Treiber, Daniel K, Gallant, Paul, Atteridge, Corey E, Campbell, Brian T, Chan, Katrina W, Ciceri, Pietro, Davis, Mindy I, Edeen, Philip T, Faraoni, Raffaella, Floyd, Mark, Hunt, Jeremy P, Lockhart, Daniel J, Milanov, Zdravko V, Morrison, Michael J, Pallares, Gabriel, Patel, Hitesh K, Pritchard, Stephanie, Wodicka, Lisa M

“…Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets 1 , 2 . The biological consequences of multi-kinase activity…”
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Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK) by Asquith, Christopher R.M., Treiber, Daniel K., Zuercher, William J.

“…[Display omitted] We demonstrate an innovative approach for optimization of kinase inhibitor potency and selectivity utilising kinase mini-panels and…”
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Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit by Gerstenberger, Brian S, Trzupek, John D, Tallant, Cynthia, Fedorov, Oleg, Filippakopoulos, Panagis, Brennan, Paul E, Fedele, Vita, Martin, Sarah, Picaud, Sarah, Rogers, Catherine, Parikh, Mihir, Taylor, Alexandria, Samas, Brian, O’Mahony, Alison, Berg, Ellen, Pallares, Gabriel, Torrey, Adam D, Treiber, Daniel K, Samardjiev, Ivan J, Nasipak, Brian T, Padilla-Benavides, Teresita, Wu, Qiong, Imbalzano, Anthony N, Nickerson, Jeffrey A, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Owen, Dafydd R

“…The acetyl post-translational modification of chromatin at selected histone lysine residues is interpreted by an acetyl-lysine specific interaction with…”
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Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases by Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.

“…To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in…”
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Kinetic Intermediates Trapped by Native Interactions in RNA Folding by Treiber, Daniel K., Rook, Martha S., Zarrinkar, Patrick P., Williamson, James R.

“…In the magnesium ion-dependent folding of the Tetrahymena ribozyme, a kinetic intermediate accumulates in which the P4-P6 domain is formed, but the P3-P7…”
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Ins and Outs of Kinase DFG Motifs by Treiber, Daniel K., Shah, Neil P.

“…In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known “gatekeeper” residue,…”
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Donated chemical probes for open science by Müller, Susanne, Ackloo, Suzanne, Arrowsmith, Cheryl H, Bauser, Marcus, Baryza, Jeremy L, Blagg, Julian, Böttcher, Jark, Bountra, Chas, Brown, Peter J, Bunnage, Mark E, Carter, Adrian J, Damerell, David, Dötsch, Volker, Drewry, David H, Edwards, Aled M, Edwards, James, Elkins, Jon M, Fischer, Christian, Frye, Stephen V, Gollner, Andreas, Grimshaw, Charles E, IJzerman, Adriaan, Hanke, Thomas, Hartung, Ingo V, Hitchcock, Steve, Howe, Trevor, Hughes, Terry V, Laufer, Stefan, Li, Volkhart Mj, Liras, Spiros, Marsden, Brian D, Matsui, Hisanori, Mathias, John, O'Hagan, Ronan C, Owen, Dafydd R, Pande, Vineet, Rauh, Daniel, Rosenberg, Saul H, Roth, Bryan L, Schneider, Natalie S, Scholten, Cora, Singh Saikatendu, Kumar, Simeonov, Anton, Takizawa, Masayuki, Tse, Chris, Thompson, Paul R, Treiber, Daniel K, Viana, Amélia Yi, Wells, Carrow I, Willson, Timothy M, Zuercher, William J, Knapp, Stefan, Mueller-Fahrnow, Anke

“…Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical…”
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An Optimal Mg2+ Concentration for Kinetic Folding of the Tetrahymena Ribozyme by Rook, Martha S., Treiber, Daniel K., Williamson, James R.

“…Divalent metal ions, such as Mg2+, are generally required for tertiary structure formation in RNA. Although the role of Mg2+ binding in RNA-folding equilibria…”
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A small molecule-kinase interaction map for clinical kinase inhibitors by Zarrinkar, Patrick P, Floyd, Mark, Lai, Andiliy G, Atteridge, Corey E, Carter, Todd A, Galvin, Margaret, Mehta, Shamal A, Lélias, Jean-Michel, Wodicka, Lisa M, Benedetti, Michael G, Azimioara, Mihai D, Treiber, Daniel K, Insko, Darren E, Insko, Michael A, Edeen, Philip T, Gerlach, Jay L, Fabian, Miles A, Grotzfeld, Robert M, Lockhart, David J, Patel, Hitesh K, Milanov, Zdravko V, Ciceri, Pietro, Biggs, William H, Herrgard, Sanna, Velasco, Anne Marie, Ford, Julia M

“…Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring…”
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Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor VX-680 by YOUNG, Matthew A, SHAH, Neil P, SAWYERS, Charles L, KURIYAN, John, CHAO, Luke H, SEELIGER, Markus, MILANOV, Zdravko V, BIGGS, William H, TREIBER, Daniel K, PATEL, Hitesh K, ZARRINKAR, Patrick P, LOCKHART, David J

“…We present a high-resolution (2.0 A) crystal structure of the catalytic domain of a mutant form of the Abl tyrosine kinase (H396P; Abl-1a numbering) that is…”
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Beyond kinetic traps in RNA folding by Treiber, Daniel K, Williamson, James R

“…Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics. Several interdependent parameters that…”
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Exposing the kinetic traps in RNA folding by Treiber, Daniel K, Williamson, James R

“…Large ribozymes fold on a ‘glacials timescale compared to the folding of their protein counterparts. The sluggish folding exhibited by large RNAs results from…”
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Activation State-Dependent Binding of Small Molecule Kinase Inhibitors: Structural Insights from Biochemistry by Wodicka, Lisa M., Ciceri, Pietro, Davis, Mindy I., Hunt, Jeremy P., Floyd, Mark, Salerno, Sara, Hua, Xuequn H., Ford, Julia M., Armstrong, Robert C., Zarrinkar, Patrick P., Treiber, Daniel K.

“…Interactions between kinases and small molecule inhibitors can be activation state dependent. A detailed understanding of inhibitor binding therefore requires…”
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Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors by Abraham, Sunny, Hadd, Michael J., Tran, Lan, Vickers, Troy, Sindac, Janice, Milanov, Zdravko V., Holladay, Mark W., Bhagwat, Shripad S., Hua, Helen, Ford Pulido, Julia M., Cramer, Merryl D., Gitnick, Dana, James, Joyce, Dao, Alan, Belli, Barbara, Armstrong, Robert C., Treiber, Daniel K., Liu, Gang

“…The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. The synthesis and SAR for a novel series of…”
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Discovery of Highly Potent and Selective Pan-Aurora Kinase Inhibitors with Enhanced in Vivo Antitumor Therapeutic Index by Liu, Gang, Abraham, Sunny, Tran, Lan, Vickers, Troy D, Xu, Shimin, Hadd, Michael J, Quiambao, Sheena, Holladay, Mark W, Hua, Helen, Ford Pulido, Julia M, Gunawardane, Ruwanthi N, Davis, Mindy I, Eichelberger, Shawn R, Apuy, Julius L, Gitnick, Dana, Gardner, Michael F, James, Joyce, Breider, Mike A, Belli, Barbara, Armstrong, Robert C, Treiber, Daniel K

“…Serine/threonine protein kinases Aurora A, B, and C play essential roles in cell mitosis and cytokinesis. Currently a number of Aurora kinase inhibitors with…”
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Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors by Patel, Hitesh K., Grotzfeld, Robert M., Lai, Andiliy G., Mehta, Shamal A., Milanov, Zdravko V., Chao, Qi, Sprankle, Kelly G., Carter, Todd A., Velasco, Anne Marie, Fabian, Miles A., James, Joyce, Treiber, Daniel K., Lockhart, David J., Zarrinkar, Patrick P., Bhagwat, Shripad S.

“…A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral…”
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Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases by Liu, Gang, Campbell, Brian T, Holladay, Mark W, Ford Pulido, Julia M, Hua, Helen, Gitnick, Dana, Gardner, Michael F, James, Joyce, Breider, Mike A, Brigham, Daniel, Belli, Barbara, Armstrong, Robert C, Treiber, Daniel K

“…A series of potent, selective platelet-derived growth factor receptor-family kinase inhibitors was optimized starting from a globally selective lead molecule 4…”
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