Search Results - "Tregouet, David A."

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension by Germain, Marine, Eyries, Mélanie, Montani, David, Poirier, Odette, Girerd, Barbara, Dorfmüller, Peter, Coulet, Florence, Nadaud, Sophie, Maugenre, Svetlana, Guignabert, Christophe, Carpentier, Wassila, Vonk-Noordegraaf, Anton, Lévy, Marilyne, Chaouat, Ari, Lambert, Jean-Charles, Bertrand, Marion, Dupuy, Anne-Marie, Letenneur, Luc, Lathrop, Mark, Amouyel, Philippe, de Ravel, Thomy J L, Delcroix, Marion, Austin, Eric D, Robbins, Ivan M, Hemnes, Anna R, Loyd, James E, Berman-Rosenzweig, Erika, Barst, Robyn J, Chung, Wendy K, Simonneau, Gerald, Trégouët, David A, Humbert, Marc, Soubrier, Florent

“…Florent Soubrier and colleagues report a genome-wide association study of pulmonary arterial hypertension. They identify a susceptibility locus near CBLN2…”
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Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy by Suffee, Nadine, Moore-Morris, Thomas, Jagla, Bernd, Mougenot, Nathalie, Dilanian, Gilles, Berthet, Myriam, Proukhnitzky, Julie, Le Prince, Pascal, Tregouet, David A., Pucéat, Michel, Hatem, Stéphane N.

“…Fibro-fatty infiltration of subepicardial layers of the atrial wall has been shown to contribute to the substrate of atrial fibrillation. Here, we examined if…”
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Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men by Russo, Paola, Strazzullo, Pasquale, Cappuccio, Francesco P., Tregouet, David A., Lauria, Fabio, Loguercio, Maria, Barba, Gianvincenzo, Versiero, Marco, Siani, Alfonso

“…Context: The endocannabinoid system modulates food intake and body weight in animal models. Treatment with the cannabinoid type 1 receptor blocker, rimonabant,…”
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Effect of cytochrome P450 2C19 genotype on voriconazole exposure in cystic fibrosis lung transplant patients by Berge, Maud, Guillemain, Romain, Trégouet, David A, Amrein, Catherine, Boussaud, Veronique, Chevalier, Patrick, Lillo-Lelouet, Agnes, Le Beller, Christine, Laurent-Puig, Pierre, Beaune, Philippe H, Billaud, Eliane M, Loriot, Marie-Anne

“…Purpose Voriconazole is widely used to treat invasive aspergillosis after lung transplantation. In cystic fibrosis patients, the interindividual variability in…”
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A large‐scale exome array analysis of venous thromboembolism by Lindström, Sara, Brody, Jennifer A., Turman, Constance, Germain, Marine, Bartz, Traci M., Smith, Erin N., Chen, Ming‐Huei, Puurunen, Marja, Chasman, Daniel, Hassler, Jeffrey, Pankratz, Nathan, Basu, Saonli, Guan, Weihua, Gyorgy, Beata, Ibrahim, Manal, Empana, Jean‐Philippe, Olaso, Robert, Jackson, Rebecca, Brækkan, Sigrid K., McKnight, Barbara, Deleuze, Jean‐Francois, O’Donnell, Cristopher J., Jouven, Xavier, Frazer, Kelly A., Psaty, Bruce M., Wiggins, Kerri L., Taylor, Kent, Reiner, Alexander P., Heckbert, Susan R., Kooperberg, Charles, Ridker, Paul, Hansen, John‐Bjarne, Tang, Weihong, Johnson, Andrew D., Morange, Pierre‐Emmanuel, Trégouët, David A., Kraft, Peter, Smith, Nicholas L., Kabrhel, Christopher

“…Although recent Genome‐Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome‐wide search for…”
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The Factor XII −4C>T Variant and Risk of Common Thrombotic Disorders: A HuGE Review and Meta-Analysis of Evidence From Observational Studies by Johnson, Candice Y., Tuite, Ashleigh, Morange, Pierre E., Tregouet, David A., Gagnon, France

“…Coagulation factor XII is involved in thrombus formation and therefore may play a role in the etiology of thrombotic disorders. A common variant in the factor…”
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Association between Angiotensin-Converting Enzyme gene polymorphisms and diabetic nephropathy : Case-control, haplotype, and family-based study in three European Populations by HADJADJ, Samy, TARNOW, Lise, THEVA, Alexandre, GAUGUIER, Dominique, FARRALL, Martin, COX, Roger, MATSUDA, Fumihiko, LATHROP, Mark, HAGER-VIONNET, Nathalie, FORSBLOM, Carol, KAZEEM, Gbenga, MARRE, Michel, GROOP, Per-Henrik, PARVING, Hans-Henrik, CAMBIEN, Francois, TREGOUET, David A, GUT, Ivo G

“…Angiotensin 1-converting enzyme gene (ACE) is a risk factor for diabetic nephropathy (DN) in patients with type 1 diabetes. The selection of this candidate…”
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Gender-Specific Association of a Perilipin Gene Haplotype with Obesity Risk in a White Population by Qi, Lu, Shen, Haiqing, Larson, Ilona, Schaefer, Ernst J., Greenberg, Andrew S., Tregouet, David A., Corella, Dolores, Ordovas, Jose M.

“…Objective: Perilipin is a class of protein‐coating lipid droplets in adipocytes and steroidogenic cells. Our purpose was to examine the association between…”
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Common Risk Factors Add to Inherited Thrombophilia to Predict Venous Thromboembolism Risk in Families by Suchon, Pierre, Resseguier, Noemie, Ibrahim, Manal, Robin, Alexia, Venton, Geoffroy, Barthet, Marie-Christine, Brunet, Dominique, Saut, Noemie, Alessi, Marie-Christine, Trégouët, David A, Morange, Pierre E

“…The clinical venous thromboembolism (VTE) pattern often shows wide heterogeneity within relatives of a VTE-affected family, although they carry the same…”
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Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth by JAQUET, Delphine, TREGOUËT, David A, GODEFROY, Thierry, NICAUD, Viviane, CHEVENNE, Didi, TIRET, Laurence, CZERNICHOW, Paul, LEVY-MARCHAL, Claire

“…Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth Delphine Jaquet 1 , David A. Trégouët 2 ,…”
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Associations of PPARGC1A haplotypes with plaque score but not with intima-media thickness of carotid arteries in middle-aged subjects by IGLSEDER, Bernhard, OBERKOFLER, Hannes, FELDER, Thomas K, KLEIN, Kerstin, PAULWEBER, Bernhard, KREMPLER, Franz, TREGOUET, David A, PATSCH, Wolfgang

“…Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC-1alpha, PPARGC1A) integrates the transcriptional program of mitochondrial biogenesis…”
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A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy by VILLARD, Eric, PERRET, Claire, DUBOURG, Olivier, TAVAZZI, Luigi, AUMONT, Marie-Claude, DEGROOTE, Pascal, FAUCHIER, Laurent, TROCHU, Jean-Noël, GIBELIN, Pierre, AUPETIT, Jean-François, STARK, Klaus, ERDMANN, Jeanette, GARY, Françoise, HETZER, Roland, ROBERT, Angharad M, BARTON, Paul J. R, REGITZ-ZAGROSEK, Vera, ASLAM, Uzma, DUBOSCQ-BIDOT, Laëtitia, MEYBORG, Matthias, MAISCH, Bernhard, MADEIRA, Hugo, WALDENSTRÖM, Anders, PROUST, Carole, GALVE, Enrique, CLELAND, John G, DORENT, Richard, ROIZES, Gerard, ZELLER, Tanja, BLANKENBERG, Stefan, GOODALL, Alison H, COOK, Stuart, TREGOUET, David A, TIRET, Laurence, DITANIAN, Gilles, ISNARD, Richard, KOMAJDA, Michel, CHARRON, Philippe, CAMBIEN, François, HENGSTENBERG, Christian, RUPPERT, Volker, ARBUSTINI, Eloisa, WICHTER, Thomas, GERMAIN, Marine

“…Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We…”
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Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study by Lindström, Sara, Germain, Marine, Crous-Bou, Marta, Smith, Erin N., Morange, Pierre-Emmanuel, van Hylckama Vlieg, Astrid, de Haan, Hugoline G., Chasman, Daniel, Ridker, Paul, Brody, Jennifer, de Andrade, Mariza, Heit, John A., Tang, Weihong, DeVivo, Immaculata, Grodstein, Francine, Smith, Nicholas L., Tregouet, David, Kabrhel, Christopher

“…Observational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due…”
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Exome Sequencing Studies Identify Mutations in STAB2 As a Genetic Risk for Venous Thromboembolic Disease by Desch, Karl, Ozel, Ayse Bilge, Halvorsen, Matthew, Michels, Alison L., Swystun, Laura L, Mokry, Lauren, Richards, Brent, Germain, Marine, Tregouet, David A., Reitsma, Pieter H., Kearon, Clive, Li, Jun Z, Goldstein, David B., Lillicrap, David, Ginsburg, David

“…Deep vein thrombosis and pulmonary embolism, collectively referred to as venous thromboembolism (VTE), are the third leading cause of cardiovascular death in…”
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A PRDX1 mutant allele causes a MMACHC secondary epimutation in cblC patients by Guéant, Jean-Louis, Chéry, Céline, Oussalah, Abderrahim, Nadaf, Javad, Coelho, David, Josse, Thomas, Flayac, Justine, Robert, Aurélie, Koscinski, Isabelle, Gastin, Isabelle, Filhine-Tresarrieu, Pierre, Pupavac, Mihaela, Brebner, Alison, Watkins, David, Pastinen, Tomi, Montpetit, Alexandre, Hariri, Fadi, Tregouët, David, Raby, Benjamin A, Chung, Wendy K., Morange, Pierre-Emmanuel, Froese, D. Sean, Baumgartner, Matthias R., Benoist, Jean-François, Ficicioglu, Can, Marchand, Virginie, Motorin, Yuri, Bonnemains, Chrystèle, Feillet, François, Majewski, Jacek, Rosenblatt, David S.

“…To date, epimutations reported in man have been somatic and erased in germlines. Here, we identify a cause of the autosomal recessive cblC class of inborn…”
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Abstract 564: Influence of Coronary Artery Disease-Associated Genetic Variants on Risk of Venous Thromboembolism by Bruzelius, Maria, Strawbridge, Rona J, Tregouet, David A, Bergendal, Annica, Silveira, Angela, Gertow, Karl, Sundström, Anders, Kieler, Helle, Syvänen, Ann-Christine, Morange, Pierre-Emmanuel, Odeberg, Jacob, Hamsten, Anders

“…Abstract only Objective To determine whether genetic variation robustly associated with coronary artery disease (CAD) also influences risk of venous…”
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Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm by TREGOUET, D.-A, TIRET, L

“…It is now widely recognized that haplotype information inferred from genotypes can be of great interest to better characterize the role of a candidate gene in…”
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