Search Results - "Treffers, Louise W"

Neutrophils in cancer by Treffers, Louise W., Hiemstra, Ida H., Kuijpers, Taco W., van den Berg, Timo K., Matlung, Hanke L.

“…Summary Neutrophils play an important role in cancer. This does not only relate to the well‐established prognostic value of the presence of neutrophils, either…”
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Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis by Matlung, Hanke L., Babes, Liane, Zhao, Xi Wen, van Houdt, Michel, Treffers, Louise W., van Rees, Dieke J., Franke, Katka, Schornagel, Karin, Verkuijlen, Paul, Janssen, Hans, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Leusen, Jeanette H.W., Boelens, Jaap J., Kuhnle, Ingrid, van der Werff Ten Bosch, Jutte, Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Matozaki, Takashi, Suzuki, Eiji, Menke-van der Houven van Oordt, Catharina Willemien, van Bruggen, Robin, Roos, Dirk, van Lier, Rene A.W., Kuijpers, Taco W., Kubes, Paul, van den Berg, Timo K.

“…Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be…”
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SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage by Hendriks, Ivo A., Treffers, Louise W., Verlaan-de Vries, Matty, Olsen, Jesper V., Vertegaal, Alfred C.O.

“…Small ubiquitin-like modifiers play critical roles in the DNA damage response (DDR). To increase our understanding of SUMOylation in the mammalian DDR, we…”
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FcγRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils by Treffers, Louise W, van Houdt, Michel, Bruggeman, Christine W, Heineke, Marieke H, Zhao, Xi Wen, van der Heijden, Joris, Nagelkerke, Sietse Q, Verkuijlen, Paul J J H, Geissler, Judy, Lissenberg-Thunnissen, Suzanne, Valerius, Thomas, Peipp, Matthias, Franke, Katka, van Bruggen, Robin, Kuijpers, Taco W, van Egmond, Marjolein, Vidarsson, Gestur, Matlung, Hanke L, van den Berg, Timo K

“…The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and abundantly expressed on human granulocytes, is not clear. Unlike the…”
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C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro by Temming, A Robin, Tammes Buirs, Matthias, Bentlage, Arthur E H, Treffers, Louise W, Feringa, Hannah, de Taeye, Steven W, Kuijpers, Taco W, Nagelkerke, Sietse Q, Brasser, Giso, Mok, Juk Yee, van Esch, Wim J E, van den Berg, Timo K, Rispens, Theo, van der Schoot, C Ellen, Vidarsson, Gestur

“…Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell…”
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Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile by Bruggeman, Christine W, Dekkers, Gillian, Bentlage, Arthur E H, Treffers, Louise W, Nagelkerke, Sietse Q, Lissenberg-Thunnissen, Suzanne, Koeleman, Carolien A M, Wuhrer, Manfred, van den Berg, Timo K, Rispens, Theo, Vidarsson, Gestur, Kuijpers, Taco W

“…Abs of the IgG isotype are glycosylated in their Fc domain at a conserved asparagine at position 297. Removal of the core fucose of this glycan greatly…”
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Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody‐dependent cellular cytotoxicity towards cancer cells by Treffers, Louise W., Zhao, Xi Wen, der Heijden, Joris, Nagelkerke, Sietse Q., Rees, Dieke J., Gonzalez, Patricia, Geissler, Judy, Verkuijlen, Paul, Houdt, Michel, Boer, Martin, Kuijpers, Taco W., van den Berg, Timo K., Matlung, Hanke L.

“…The efficacy of cancer therapeutic antibodies varies considerably among patients. Anti‐cancer antibodies act through different mechanisms, including…”
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Sodium stibogluconate and CD47-SIRPα blockade overcome resistance of anti-CD20–opsonized B cells to neutrophil killing by van Rees, Dieke J., Brinkhaus, Maximilian, Klein, Bart, Verkuijlen, Paul, Tool, Anton T.J., Schornagel, Karin, Treffers, Louise W., van Houdt, Michel, Kater, Arnon P., Vidarsson, Gestur, Gennery, Andrew R., Kuijpers, Taco W., van Bruggen, Robin, Matlung, Hanke L., van den Berg, Timo K.

“…Anti-CD20 antibodies such as rituximab are broadly used to treat B-cell malignancies. These antibodies can induce various effector functions, including immune…”
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