Search Results - "Treff, N. R."

Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit by Franasiak, J. M., Werner, M. D., Juneau, C. R., Tao, X., Landis, J., Zhan, Y., Treff, N. R., Scott, R. T.

“…Purpose Characterization of the human microbiome has become more precise with the application of powerful molecular tools utilizing the unique 16S ribosomal…”
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Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates by Forman, E.J., Tao, X., Ferry, K.M., Taylor, D., Treff, N.R., Scott, R.T.

“…BACKGROUND Single embryo transfer (SET) provides the most certain means to reduce the risk of multiple gestation. Regrettably, prospective trials of SET have…”
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A deleterious mutation in the PEX2 gene causes Zellweger syndrome in individuals of Ashkenazi Jewish descent by Fedick, A., Jalas, C., Treff, N.R.

“…Zellweger syndrome is known to be caused by numerous mutations that occur in at least 12 of the PEX genes. While phenotypes vary, many are severely…”
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Carrier screening of RTEL1 mutations in the Ashkenazi Jewish population by Fedick, A.M., Shi, L., Jalas, C., Treff, N.R., Ekstein, J., Kornreich, R., Edelmann, L., Mehta, L., Savage, S.A.

“…Hoyeraal–Hreidarsson syndrome (HH) is a clinically severe variant of dyskeratosis congenita (DC), characterized by cerebellar hypoplasia, microcephaly,…”
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Carrier frequency of two BBS2 mutations in the Ashkenazi population by Fedick, A., Jalas, C., Abeliovich, D., Krakinovsky, Y., Ekstein, J., Ekstein, A., Treff, N.R.

“…Bardet–Biedl syndrome (BBS) is known to be caused by numerous mutations that occur in at least 15 of the BBS genes. As the disease follows an autosomal…”
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A founder mutation in the TCIRG1 gene causes osteopetrosis in the Ashkenazi Jewish population by Anderson, S.L., Jalas, C., Fedick, A., Reid, K.F., Carpenter, T.O., Chirnomas, D., Treff, N.R., Ekstein, J., Rubin, B.Y.

“…Osteopetrosis is a rare and heterogeneous genetic disorder characterized by dense bone mass that is a consequence of defective osteoclast function and/or…”
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SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts by Northrop, L.E., Treff, N.R., Levy, B., Scott, R.T.

“…Although selection of chromosomally normal embryos has the potential to improve outcomes for patients undergoing IVF, the clinical impact of aneuploidy…”
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Preclinical validation of a targeted next generation sequencing-based comprehensive chromosome screening methodology in human blastocysts by Zimmerman, R S, Tao, X, Marin, D, Werner, M D, Hong, K H, Lonczak, A, Landis, J, Taylor, D, Zhan, Y, Scott, R T, Treff, N R

“…Abstract STUDY QUESTION Can a novel targeted next generation sequencing (tNGS) platform accurately detect whole chromosome aneuploidy in a trophectoderm biopsy…”
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Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid by Forman, E.J., Treff, N.R., Stevens, J.M., Garnsey, H.M., Katz-Jaffe, M.G., Scott, R.T., Schoolcraft, W.B.

“…STUDY QUESTION When a chromosome aneuploidy is detected in the first polar body and a reciprocal loss or gain of the same chromosome is detected in the second…”
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Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential by Salvaggio, C. N., Forman, E. J., Garnsey, H. M., Treff, N. R., Scott, R. T.

“…Purpose Polar body (polar body) biopsy represents one possible solution to performing comprehensive chromosome screening (CCS). This study adds to what is…”
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High-mobility group A1a protein regulates Ras ERK signaling in MCF-7 human breast cancer cells by Treff, Nathan R, Pouchnik, Derek, Dement, Gregory A, Britt, Rachel L, Reeves, Raymond

“…High-mobility group (HMG) A1 proteins are gene regulatory factors whose overexpression is frequently observed in naturally occurring human cancers. The…”
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Dynamic mitochondrial localization of nuclear transcription factor HMGA1 by Dement, Gregory A., Treff, Nathan R., Magnuson, Nancy S., Franceschi, Vincent, Reeves, Raymond

“…It has been well established that high mobility group A1 (HMGA1) proteins act within the nucleus of mammalian cells as architectural transcription factors that…”
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Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells by TREFF, Nathan R, DEMENT, Gregory A, ADAIR, Jennifer E, BRITT, Rachel L, RONG NIE, SHIMA, James E, TAYLOR, Wayne E, REEVES, Raymond

“…KIT ligand (KL) and its receptor, c-kit, are coexpressed in many types of cancer cells and have been implicated in tumor growth and angiogenesis. While Sertoli…”
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Sequence and analysis of the murine Hmgiy ( Hmga1) gene locus by Pedulla, Marisa L, Treff, Nathan R, Resar, Linda M.S, Reeves, Raymond

“…The HMGIY non-histone proteins play important roles as architectural transcription factors that regulate gene transcription in mammalian cells and also act as…”
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SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH by Treff, Nathan R., Levy, Brynn, Su, Jing, Northrop, Lesley E., Tao, Xin, Scott, Richard T.

“…Many studies estimate that chromosomal mosaicism within the cleavage-stage human embryo is high. However, comparison of two unique methods of aneuploidy…”
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SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts : Molecular Diagnostics in Assisted Reproduction by NORTHROP, L. E, TREFF, N. R, LEVY, B, SCOTT, R. T

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Tracking embryo implantation using cell-free fetal DNA enriched from maternal circulation at 9 weeks gestation by Treff, Nathan R., Tao, Xin, Su, Jing, Lonczak, Agnieszka, Northrop, Lesley E., Ruiz, Andrew A., Scott, Richard T.

“…Embryo DNA fingerprinting represents an important tool for tracking embryo-specific outcomes after multiple embryo transfer during IVF. The situation in which…”
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RESTRAINT STRESS DOES NOT ALTER PLACENTAL ANDROSTENEDIONE SECRETION IN PREGNANT RATS by Carlberg, K. A., Vanhoose, A. M., Shaffer, M., Treff, N. R.

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