Search Results - "Tree, T I"

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes by Mannering, S.I, Wong, F.S, Durinovic-Belló, I, Brooks-Worrell, B, Tree, T.I, Cilio, C.M, Schloot, N.C, Mallone, R

“…Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no…”
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Allograft‐Specific Cytokine Profiles Associate with Clinical Outcome After Islet Cell Transplantation by Huurman, V. A. L., Velthuis, J. H. L., Hilbrands, R., Tree, T. I. M., Gillard, P., Van Der Meer‐Prins, P. M. W., Duinkerken, G., Pinkse, G. G. M., Keymeulen, B., Roelen, D. L., Claas, F. H. J., Pipeleers, D. G., Roep, B. O.

“…Islet cell transplantation can cure type 1 diabetes, but allograft rejection and recurrent autoimmunity may contribute to decreasing insulin independence over…”
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Historical and new insights into pathogenesis of type 1 diabetes (2) by Wong, F. S., Tree, T. I.

“…Summary In this second and final part of the collection of articles for the Immunology of Diabetes Society review series on insights into pathogenesis of type…”
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Historical and new insights into pathogenesis of type 1 diabetes by Wong, F. S., Tree, T. I.

“…Summary In recent years, there have been exciting new insights into pathogenesis of type 1 diabetes in a number of areas of immunology. In this edition, a…”
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Persistent C‐peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice? by Marren, S. M., Hammersley, S., McDonald, T. J., Shields, B. M., Knight, B. A., Hill, A., Bolt, R., Tree, T. I., Roep, B. O., Hattersley, A. T., Jones, A. G., Oram, R. A.

“…Aims Most people with Type 1 diabetes have low levels of persistent endogenous insulin production. The Diabetes Control and Complications Trial showed that…”
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Identifying the ‘Achilles heel’ of type 1 diabetes by Battaglia, M., Buckner, J. H., Levings, M. K., Richardson, S. J., Wong, F. S., Tree, T. I.

“…Summary When Thetis dipped her son Achilles into the River Styx to make him immortal, she held him by the heel, which was not submerged, and thus created a…”
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Increased resistance to CD4+CD25hi regulatory T cell‐mediated suppression in patients with type 1 diabetes by Lawson, J. M., Tremble, J., Dayan, C., Beyan, H., Leslie, R. D. G., Peakman, M., Tree, T. I. M.

“…Summary Type I diabetes (T1D) is a T cell‐mediated autoimmune disease characterized by loss of tolerance to islet autoantigens, leading to the destruction of…”
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Persistent C-peptide is associated with reduced hypoglycaemia but not HbA 1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice? by Marren, S M, Hammersley, S, McDonald, T J, Shields, B M, Knight, B A, Hill, A, Bolt, R, Tree, T I, Roep, B O, Hattersley, A T, Jones, A G, Oram, R A

“…Most people with Type 1 diabetes have low levels of persistent endogenous insulin production. The Diabetes Control and Complications Trial showed that close to…”
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Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules by ASTILL, T. P, ELLIS, R. J, ARIF, S, TREE, T. I. M, PEAKMAN, M

“…Presentation of peptide epitopes derived from beta-cell autoantigens, such as insulin and its precursor molecules, by MHC class II molecules to autoreactive…”
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Evidence for recognition of novel islet T cell antigens by granule‐specific T cell lines from new onset type 1 diabetic patients by Tree, T. I. M., O'Byrne, D., Tremble, J. M., Macfarlane, W. M., Haskins, K., James, R. F. L., Docherty, K., Hutton, J. C., Banga, J. P.

“…Type 1 diabetes is a T cell‐mediated autoimmune disease where a number of islet β‐cell target autoantigens have been characterized on the basis of reactivity…”
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Resistance to Onchocerca volvulus: Differential Cellular and Humoral Responses to a Recombinant Antigen, OvMBP20/11 by Bradley, Janette E., Elson, Lynne, Tree, Timothy I. M., Stewart, Graham, Guderian, Ronald, Calvopiña, Manual, Paredes, Wilson, Araujo, Edmundo, Nutman, Thomas B.

“…Persons putatively immune (PI) to Onchocerca volvulus (Ov) infection were identified in Ecuador on the basis of epidemiologic, clinical, and parasitologic…”
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The novel cuticular collagen Ovcol-1 of Onchocerca volvulus is preferentially recognized by immunoglobulin G3 from putatively immune individuals by STEWART, G. R, ZHU, Y, PARREDES, W, TREE, T. I. M, GUDERIAN, R, BRADLEY, J. E

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of Autoreactive T-cells in type 1 Diabetes report of phase II of the second international Immunology of Diabetes Society workshop for standardization of T-cell assays in type 1 Diabetes by PEAKMAN, Mark, TREE, Timothy I, ENDL, Josef, VAN ENDERT, Peter, ATKINSON, Mark A, ROEP, Bart O

“…The identification, quantification, and characterization of T-cells reactive with the islet autoantigens GAD65, proinsulin (PI), and tyrosine phosphatase-like…”
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Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients by TREE, T. I. M, O'BYRNE, D, TREMBLE, J. M, MACFARLANE, W. M, HASKINS, K, JAMES, R. F. L, DOCHERTY, K, HUTTON, J. C, BANGA, J. P

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Heterogeneity of IgG antibody responses to cloned Onchocerca volvulus antigens in microfiladermia positive individuals from Esmeraldas Province, Ecuador by Trenholme, K R, Tree, T I, Gillespie, A J, Guderian, R, Maizels, R M, Bradley, J E

“…The prevalence of IgG antibodies to three recombinant O. volvulus antigens, OvMBP/10, OvMBP/11 and OvMBP/29 was determined in a group of 94 microfilaria…”
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Onchocerca volvulus: characterization of an immunodominant hypodermal antigen present in adult and larval parasites by Bradley, J E, Tuan, R S, Shepley, K J, Tree, T I, Maizels, R M, Helm, R, Gregory, W F, Unnasch, T R

“…Biochemical and immunological data suggest that a relatively limited number of polypeptide antigens of viable Onchocerca volvulus-infective larvae are…”
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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health by Arif, Sefina, Tree, Timothy I., Astill, Thomas P., Tremble, Jennifer M., Bishop, Amanda J., Dayan, Colin M., Roep, Bart O., Peakman, Mark

“…According to the quality of response they mediate, autoreactive T cells recognizing islet β cell peptides could represent both disease effectors in the…”
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Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies by Tree, T I, Morgenthaler, N G, Duhindan, N, Hicks, K E, Madec, A M, Scherbaum, W A, Banga, J P

“…Glutamic acid decarboxylase 65 is a major autoantigen in Type I (insulin-dependent) diabetes mellitus, autoimmune polyendocrine syndrome and stiff-man…”
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Two amino acids in glutamic acid decarboxylase act in concert for maintainance of conformational determinants recognised by Type I diabetic autoantibodies by TREE, T. I. M, MORGENTHALER, N. G, DUHINDAN, N, HICKS, K. E, MADEC, A.-M, SCHERBAUM, W. A, BANGA, J. P

“…Aims/hypothesis. Glutamic acid decarboxylase 65 is a major autoantigen in Type I (insulin-dependent) diabetes mellitus, autoimmune polyendocrine syndrome and…”
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Characterisation of an immunodominant glycoprotein antigen of Onchocerca volvulus with homologues in other filarial nematodes and Caenorhabditis elegans by Tree, Timothy I.M., Gillespie, Andrew J., Shepley, Kenneth J., Blaxter, Mark L., Tuan, Rocky S., Bradley, Janette E.

“…The full-length cDNA corresponding to an Onchocerca volvulus antigen, OvMBP 11 , which had been selected as a serodiagnostic tool was isolated, sequenced, and…”
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