Search Results - "Treco, Douglas"
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1
Template-directed synthesis of a genetic polymer in a model protocell
Published in Nature (03-07-2008)“…Contemporary phospholipid-based cell membranes are formidable barriers to the uptake of polar and charged molecules ranging from metal ions to complex…”
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2
Effect of Stalling after Mismatches on the Error Catastrophe in Nonenzymatic Nucleic Acid Replication
Published in Journal of the American Chemical Society (28-04-2010)“…The frequency of errors during genome replication limits the amount of functionally important information that can be passed on from generation to generation…”
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3
Nonviral Transfer of the Gene Encoding Coagulation Factor VIII in Patients with Severe Hemophilia A
Published in The New England journal of medicine (07-06-2001)“…In some of the recipients, the plasma levels of factor VIII activity rose and bleeding diminished for up to 10 months. Hemophilia A, an X-linked hemorrhagic…”
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4
Growth and manipulation of yeast
Published in Current protocols in molecular biology (Print) (01-04-2008)“…Yeast cultures can be grown, maintained, and stored in liquid media or on agar plates using techniques similar to those for bacterial cultures. This unit…”
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An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae
Published in Nature (London) (02-03-1989)“…An initiation site for meiotic gene conversion has been identified in the promoter region of the ARG4 gene of Saccharomyces cerevisiae. The chromosome on which…”
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Double-strand breaks at an initiation site for meiotic gene conversion
Published in Nature (London) (01-03-1989)Get full text
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7
Preclinical Evaluation of RA101495, a Potent Cyclic Peptide Inhibitor of C5 for the Treatment of Paroxysmal Nocturnal Hemoglobinuria
Published in Blood (03-12-2015)“…Regulation of the terminal phase of the complement component pathway is a clinically validated approach for the therapeutic treatment of complement disorders…”
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Development of RA101348, a Potent Cyclic Peptide Inhibitor of C5 for Complement-Mediated Diseases
Published in Blood (06-12-2014)“…The involvement of complement in the pathogenesis of serious, life-threatening diseases underscores the importance in developing therapeutics to intervene in…”
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9
Abstract C212: Discovery of high affinity cyclic peptidomimetics binding Mcl-1 and Ras
Published in Molecular cancer therapeutics (01-11-2013)“…Abstract Many well-validated oncology targets regulate signaling pathways through interactions with other proteins. Addressing these targets, which often lack…”
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Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site
Published in Cell (22-03-1991)“…Meiosis-specific double-strand breaks occur at the initiation site for meiotic gene conversion in the yeast ARG4 gene. Here we show that the break fragments…”
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11
Preparation of yeast media
Published in Current protocols in molecular biology (Print) (01-07-1993)“…Preparation of sterile media of consistently high quality is essential for the genetic manipulation of yeast. Recipes for media needed in the protocols in this…”
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12
Double-strand breaks at an initiation site for meiotic gene conversion
Published in Nature (London) (02-03-1989)“…It has been proposed that the initiation of meiotic recombination involves either single-strand or double-strand breaks in DNA. It is difficult to distinguish…”
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13
Growth and manipulation of yeast
Published in Current protocols in molecular biology (Print) (01-05-2001)“…Preparation of sterile media of consistently high quality is essential for the genetic manipulation of yeast. Recipes for media needed in the protocols in this…”
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14
Genome Evolution. Based on the Proceedings of an International Symposium Held in Cambridge, England . G. A. Dover , R. B. Flavell
Published in The Quarterly review of biology (01-06-1983)Get full text
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15
Long-Term Production and Delivery of Human Growth Hormone In vivo
Published in Proceedings of the National Academy of Sciences - PNAS (08-11-1994)“…The application of somatic cell gene therapy to large patient populations will require the development of safe and practical approaches to the generation and…”
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16
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis
Published in Proceedings of the National Academy of Sciences - PNAS (01-10-1990)“…We have used denaturant-gel electrophoresis to provide a physical demonstration of heteroduplex DNA in the products of yeast meiosis. We examined heteroduplex…”
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17
Growth and manipulation of yeast
Published in Current protocols in protein science (01-05-2001)“…This unit describes preparation of selected media for growing yeast and also discusses strain storage and revival. Protocols are provided for the assay of…”
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18
The Evolutionarily Conserved Repetitive Sequence d(TG·AC)n Promotes Reciprocal Exchange and Generates Unusual Recombinant Tetrads During Yeast Meiosis
Published in Molecular and cellular biology (01-11-1986)“…We have studied the genetic behavior of the alternating copolymer d(TG·AC) n inserted into a defined position in the genome of the yeast Saccharomyces…”
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Genome Evolution. Based on the Proceedings of an International Symposium Held in Cambridge, England
Published in The Quarterly Review of Biology (01-06-1983)Get full text
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20
Distribution of Ribosomal Gene Length Variants among Mouse Chromosomes
Published in Proceedings of the National Academy of Sciences - PNAS (01-08-1982)“…The ribosomal genes (rDNA) in mouse inbred strains have a multichromosomal distribution. Using a structural feature of rDNA [variable length rDNA segment…”
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