Search Results - "Trcka, Daniel"

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell by Ayyaz, Arshad, Kumar, Sandeep, Sangiorgi, Bruno, Ghoshal, Bibaswan, Gosio, Jessica, Ouladan, Shaida, Fink, Mardi, Barutcu, Seda, Trcka, Daniel, Shen, Jess, Chan, Kin, Wrana, Jeffrey L., Gregorieff, Alex

“…The turnover of the intestinal epithelium is driven by multipotent LGR5 + crypt-base columnar cells (CBCs) located at the bottom of crypt zones 1 . However,…”
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Cell competition during reprogramming gives rise to dominant clones by Shakiba, Nika, Fahmy, Ahmed, Jayakumaran, Gowtham, McGibbon, Sophie, David, Laurent, Trcka, Daniel, Elbaz, Judith, Puri, Mira C, Nagy, Andras, van der Kooy, Derek, Goyal, Sidhartha, Wrana, Jeffrey L, Zandstra, Peter W

“…The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have…”
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A glucose meter interface for point-of-care gene circuit-based diagnostics by Amalfitano, Evan, Karlikow, Margot, Norouzi, Masoud, Jaenes, Katariina, Cicek, Seray, Masum, Fahim, Sadat Mousavi, Peivand, Guo, Yuxiu, Tang, Laura, Sydor, Andrew, Ma, Duo, Pearson, Joel D., Trcka, Daniel, Pinette, Mathieu, Ambagala, Aruna, Babiuk, Shawn, Pickering, Bradley, Wrana, Jeff, Bremner, Rod, Mazzulli, Tony, Sinton, David, Brumell, John H., Green, Alexander A., Pardee, Keith

“…Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors with the potential to provide decentralized and low-cost molecular…”
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Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2 by Pires, Layla, Wilson, Brian C., Bremner, Rod, Lang, Amanda, Larouche, Jeremie, McDonald, Ryan, Pearson, Joel D., Trcka, Daniel, Wrana, Jeff, Wu, James, Whyne, Cari M.

“…The lack of therapeutic options to fight Covid-19 has contributed to the current global pandemic. Despite the emergence of effective vaccines, development of…”
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A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2 by Aynaud, Marie-Ming, Hernandez, J. Javier, Barutcu, Seda, Braunschweig, Ulrich, Chan, Kin, Pearson, Joel D., Trcka, Daniel, Prosser, Suzanna L., Kim, Jaeyoun, Barrios-Rodiles, Miriam, Jen, Mark, Song, Siyuan, Shen, Jess, Bruce, Christine, Hazlett, Bryn, Poutanen, Susan, Attisano, Liliana, Bremner, Rod, Blencowe, Benjamin J., Mazzulli, Tony, Han, Hong, Pelletier, Laurence, Wrana, Jeffrey L.

“…Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity testing for effective management. Here, we describe “Systematic Parallel…”
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Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods by Pearson, Joel D, Trcka, Daniel, Lu, Suying, Hyduk, Sharon J, Jen, Mark, Aynaud, Marie-Ming, Hernández, J Javier, Peidis, Philippos, Barrios-Rodiles, Miriam, Chan, Kin, Woodgett, Jim, Mazzulli, Tony, Attisano, Liliana, Pelletier, Laurence, Cybulsky, Myron I, Wrana, Jeffrey L, Bremner, Rod

“…Sensitive, rapid, and accessible diagnostics continue to be critical to track the COVID-19 pandemic caused by the SARS-CoV-2 virus. RT-qPCR is the gold…”
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A single cell survey of the microbial impacts on the mouse small intestinal epithelium by Tsang, Derek K.L., Wang, Ryan J., De Sa, Oliver, Ayyaz, Arshad, Foerster, Elisabeth G., Bayer, Giuliano, Goyal, Shawn, Trcka, Daniel, Ghoshal, Bibaswan, Wrana, Jeffrey L., Girardin, Stephen E., Philpott, Dana J.

“…The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote…”
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The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks by Nakahata, Yasukazu, Akashi, Makoto, Trcka, Daniel, Yasuda, Akio, Takumi, Toru

“…Circadian rhythms are endogenous, self-sustained oscillations with approximately 24-hr rhythmicity that are manifested in various physiological and metabolic…”
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Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration by Fink, Mardi, Njah, Kizito, Patel, Shyam J., Cook, David P., Man, Vanessa, Ruso, Francesco, Rajan, Arsheen, Narimatsu, Masahiro, Obersterescu, Andreea, Pye, Melanie J., Trcka, Daniel, Chan, Kin, Ayyaz, Arshad, Wrana, Jeffrey L.

“…Cell state dynamics underlying successful tissue regeneration are undercharacterized. In the intestine, damage prompts epithelial reprogramming into revival…”
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Microbiota regulate the induction and proliferation of revival intestinal stem cells through inflammatory cytokines by Tsang, Derek K.L., Wang, Ryan J., Maisonneuve, Charles, Ayyaz, Arshad, Trcka, Daniel, Wana, Jeffrey L., Girardin, Stephen E., Philpott, Dana J.

“…Abstract Gut microbiota are critical mediators of inflammation and regeneration of the intestinal epithelium. Intestinal restitution is a coordinated response…”
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PTEN regulates cilia through Dishevelled by Shnitsar, Iryna, Bashkurov, Mikhail, Masson, Glenn R., Ogunjimi, Abiodun A., Mosessian, Sherly, Cabeza, Eduardo Aguiar, Hirsch, Calley L., Trcka, Daniel, Gish, Gerald, Jiao, Jing, Wu, Hong, Winklbauer, Rudolf, Williams, Roger L., Pelletier, Laurence, Wrana, Jeffrey L., Barrios-Rodiles, Miriam

“…Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial…”
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Robust production of uniform human cerebral organoids from pluripotent stem cells by Sivitilli, Adam A, Gosio, Jessica T, Ghoshal, Bibaswan, Evstratova, Alesya, Trcka, Daniel, Ghiasi, Parisa, Hernandez, J Javier, Beaulieu, Jean Martin, Wrana, Jeffrey L, Attisano, Liliana

“…Human cerebral organoid (hCO) models offer the opportunity to understand fundamental processes underlying human-specific cortical development and…”
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Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer by Langille, Ellen, Al-Zahrani, Khalid N, Ma, Zhibo, Liang, Minggao, Uuskula-Reimand, Liis, Espin, Roderic, Teng, Katie, Malik, Ahmad, Bergholtz, Helga, Ghamrasni, Samah El, Afiuni-Zadeh, Somaieh, Tsai, Ricky, Alvi, Sana, Elia, Andrew, Lü, YiQing, Oh, Robin H, Kozma, Katelyn J, Trcka, Daniel, Narimatsu, Masahiro, Liu, Jeff C, Nguyen, Thomas, Barutcu, Seda, Loganathan, Sampath K, Bremner, Rod, Bader, Gary D, Egan, Sean E, Cescon, David W, Sørlie, Therese, Wrana, Jeffrey L, Jackson, Hartland W, Wilson, Michael D, Witkiewicz, Agnieszka K, Knudsen, Erik S, Pujana, Miguel Angel, Wahl, Geoffrey M, Schramek, Daniel

“…Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for…”
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Discoidin Domain Receptor-1 Deficiency Attenuates Atherosclerotic Calcification and Smooth Muscle Cell-Mediated Mineralization by Ahmad, Pamela J, Trcka, Daniel, Xue, Siming, Franco, Christopher, Speer, Mei Y, Giachelli, Cecilia M, Bendeck, Michelle P

“…Intimal calcification is a feature of advanced atherosclerotic disease that predicts a two- to eightfold increase in the risk of coronary events. Type I…”
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A single cell survey of the microbial impacts on the mouse small intestinal epithelium by Tsang, Derek K.L., Wang, Ryan J., De Sa, Oliver, Ayyaz, Arshad, Foerster, Elisabeth G., Bayer, Giuliano, Goyal, Shawn, Trcka, Daniel, Ghoshal, Bibaswan, Wrana, Jeffrey L., Girardin, Stephen E., Philpott, Dana J.

“…The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote…”
Get full text