Search Results - "Traynor, J R"

A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse by Fantegrossi, W.E, Ciullo, J.R, Wakabayashi, K.T, De La Garza, R, Traynor, J.R, Woods, J.H

“…Abstract 3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) are amphetamine analogues with similar persistent neurochemical effects in the…”
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Positive allosteric modulators of the μ‐opioid receptor: a novel approach for future pain medications by Burford, N T, Traynor, J R, Alt, A

“…Morphine and other agonists of the μ‐opioid receptor are used clinically for acute and chronic pain relief and are considered to be the gold standard for pain…”
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Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model by Clark, M J, Linderman, J J, Traynor, J R

“…Regulator of G protein signaling (RGS) proteins accelerate the endogenous GTPase activity of Galpha(i/o) proteins to increase the rate of deactivation of…”
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delta-Opioid receptor subtypes and cross-talk with mu-receptors by Traynor, J R, Elliott, J

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Orphanin FQ inhibits capsaicin‐induced thermal nociception in monkeys by activation of peripheral ORL1 receptors by Ko, M C H, Naughton, N N, Traynor, J R, Song, M S, Woods, J H, Rice, K C, McKnight, A T

“…Orphanin FQ (OFQ), an endogenous peptide for ORL1 receptors, has been identified. Although the actions of OFQ have much in common with those of opioid peptides…”
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Themed section by Christie, M J, Connor, M, Traynor, J R

“…Linked Articles This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit…”
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Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH‐SY5Y cells by Alt, A, Clark, M J, Woods, J H, Traynor, J R

“…There is evidence for interactions between mu and delta opioid systems both in vitro and in vivo. This work examines the hypothesis that interaction between…”
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Differential binding properties of oripavines at cloned μ- and δ-opioid receptors by Lee, Katherine O, Akil, Huda, Woods, James H, Traynor, John R

“…This study examines the possibility that oripavine opioid receptor agonists bind equally to both high and low affinity states of the μ-opioid receptor. Studies…”
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Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, beta-funaltrexamine, and beta-chlornaltrexamine by Broadbear, J H, Sumpter, T L, Burke, T F, Husbands, S M, Lewis, J W, Woods, J H, Traynor, J R

“…The irreversible mu-opioid antagonists beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) are important pharmacological tools but have a…”
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Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists by Kumar, V., Clark, M.J., Traynor, J.R., Lewis, J.W., Husbands, S.M.

“…Opioid ligands have found use in a number of therapeutic areas, including for the treatment of pain and opiate addiction (using agonists) and alcohol addiction…”
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Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells by Traynor, J R, Nahorski, S R

“…The ability of mu-opioid agonists to activate G proteins has been demonstrated by studying the binding of the GTP analogue…”
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3-Deoxyclocinnamox:  The First High-Affinity, Nonpeptide μ-Opioid Antagonist Lacking a Phenolic Hydroxyl Group by Derrick, Ian, Neilan, Claire L, Andes, Jennifer, Husbands, Stephen M, Woods, James H, Traynor, John R, Lewis, John W

“…The C3-substituent in morphinan opioids is of critical importance; the 3-OH group is usually associated with very much higher affinity for μ-receptors than H…”
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Antinociceptive and toxic effects of (+)‐epibatidine oxalate attributable to nicotinic agonist activity by Rupniak, N.M.J., Patel, S., Marwood, R., Webb, J., Traynor, J.R., Elliott, J., Freedman, S.B., Fletcher, S.R., Hill, R.G.

“…1 Epibatidine is an analgesic substance, isolated from the skin of the poisonous frog Epipedobates tricolor, for which the mechanism of action was previously…”
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Evidence for lack of modulation of μ‐opioid agonist action by δ‐opioid agonists in the mouse vas deferens and guinea‐pig ileum by Elliott, J., Traynor, J.R.

“…1 There is evidence from in vivo studies for an interaction of μ‐ and δ‐opioid ligands. In the present work this concept has been investigated using the mouse…”
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BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice by Broom, D C, Guo, L, Coop, A, Husbands, S M, Lewis, J W, Woods, J H, Traynor, J R

“…N-Cyclopropylmethyl-[7alpha,8alpha,2', 3']-cyclohexano-1'[S]-hydroxy-6,14-endo-ethenotetrahydronororip avine (BU48) is a novel, ring-constrained analog of…”
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14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity by Moynihan, H, Jales, A R, Greedy, B M, Rennison, D, Broadbear, J H, Purington, L, Traynor, J R, Woods, J H, Lewis, J W, Husbands, S M

“…14-O-Cinnamoyl esters of naltrexone (6) were synthesized and evaluated in isolated tissue assays in vitro and in vivo in mouse antinociceptive assays. Their…”
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Neutral antagonist activity of naltrexone and 6β‐naltrexol in naïve and opioid‐dependent C6 cells expressing a µ‐opioid receptor by Divin, MF, Bradbury, FA, Carroll, FI, Traynor, JR

“…Background and purpose:  Adenylyl cyclase sensitization occurs on chronic agonist activation of µ‐opioid receptors and is manifested by an increase in cAMP…”
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14β-O-Cinnamoylnaltrexone and Related Dihydrocodeinones are Mu Opioid Receptor Partial Agonists with Predominant Antagonist Activity by Moynihan, H, Jales, A. R, Greedy, B. M, Rennison, D, Broadbear, J. H, Purington, L, Traynor, J. R, Woods, J. H, Lewis, J. W, Husbands, S. M

“…14-O-Cinnamoyl esters of naltrexone (6) were synthesized and evaluated in isolated tissue assays in vitro and in vivo in mouse antinociceptive assays. Their…”
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Differential effects of Mg2+ and other divalent cations on the binding of tritiated opioid ligands by Rodriguez, F D, Bardaji, E, Traynor, J R

“…The effects of MgCl2 on the binding of tritiated ligands to opioid binding sites in homogenates of guinea-pig brain in HEPES buffer have been studied. The…”
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Dynorphin A(1-8): stability and implications for in vitro opioid activity by Bell, K M, Traynor, J R

“…The opioid binding profile and in vitro activity of the endogenous opioid peptide dynorphin A(1-8) have been studied. At opioid receptors in guinea-pig brain…”
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