Search Results - "Traylor, Matthew"

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants by Persyn, Elodie, Hanscombe, Ken B., Howson, Joanna M. M., Lewis, Cathryn M., Traylor, Matthew, Markus, Hugh S.

“…Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three…”
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Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants by Rutten-Jacobs, Loes Ca, Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew

“…To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Prospective population based cohort study. UK Biobank Study,…”
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Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations by BEVAN, Steve, TRAYLOR, Matthew, MARKUS, Hugh S, ADIB-SAMII, Poneh, MALIK, Rainer, PAUL, Nicola L. M, JACKSON, Caroline, FARRALL, Martin, ROTHWELL, Peter M, SUDLOW, Cathie, DICHGANS, Martin

“…The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows…”
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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke by Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

“…Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal…”
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Genome-wide association study of cerebral small vessel disease reveals established and novel loci by Chung, Jaeyoon, Marini, Sandro, Pera, Joanna, Norrving, Bo, Jimenez-Conde, Jordi, Roquer, Jaume, Fernandez-Cadenas, Israel, Tirschwell, David L, Selim, Magdy, Brown, Devin L, Silliman, Scott L, Worrall, Bradford B, Meschia, James F, Demel, Stacie, Greenberg, Steven M, Slowik, Agnieszka, Lindgren, Arne, Schmidt, Reinhold, Traylor, Matthew, Sargurupremraj, Muralidharan, Tiedt, Steffen, Malik, Rainer, Debette, Stéphanie, Dichgans, Martin, Langefeld, Carl D, Woo, Daniel, Rosand, Jonathan, Anderson, Christopher D

“…Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established…”
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Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities by Malik, Rainer, Beaufort, Nathalie, Frerich, Simon, Gesierich, Benno, Georgakis, Marios K, Rannikmäe, Kristiina, Ferguson, Amy C, Haffner, Christof, Traylor, Matthew, Ehrmann, Michael, Sudlow, Cathie L M, Dichgans, Martin

“…White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and…”
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ukbtools: An R package to manage and query UK Biobank data by Hanscombe, Ken B, Coleman, Jonathan R I, Traylor, Matthew, Lewis, Cathryn M

“…The UK Biobank (UKB) is a resource that includes detailed health-related data on about 500,000 individuals and is available to the research community. However,…”
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Homogeneous case subgroups increase power in genetic association studies by Traylor, Matthew, Markus, Hugh, Lewis, Cathryn M

“…Genome-wide association studies of clinically defined cases against controls have transformed our understanding of the genetic causes of many diseases…”
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Evolution-Guided Biosynthesis of Terpenoid Inhibitors by Sarkar, Ankur, Foderaro, Tom, Kramer, Levi, Markley, Andrew L., Lee, Jessica, Traylor, Matthew J., Fox, Jerome M.

“…Terpenoids, the largest and most structurally diverse group of natural products, include a striking variety of biologically active compounds, from flavors to…”
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The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare by Hanscombe, Ken B, Persyn, Elodie, Traylor, Matthew, Glanville, Kylie P, Hamer, Mark, Coleman, Jonathan R I, Lewis, Cathryn M

“…Cardiorespiratory fitness (CRF) and physical activity (PA) are well-established predictors of morbidity and all-cause mortality. However, CRF is not routinely…”
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Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study by Larsson, Susanna C, Traylor, Matthew, Markus, Hugh S, Michaëlsson, Karl

“…We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD)…”
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Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe by Lu, Mengfei, Lewis, Cathryn M, Traylor, Matthew

“…Rapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer (DTC) genetic…”
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Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms by Lubitz, Steven A, Parsons, Owen E, Anderson, Christopher D, Benjamin, Emelia J, Malik, Rainer, Weng, Lu-Chen, Dichgans, Martin, Sudlow, Cathie L, Rothwell, Peter M, Rosand, Jonathan, Ellinor, Patrick T, Markus, Hugh S, Traylor, Matthew

“…Atrial fibrillation (AF) is a leading cause of cardioembolic stroke, but the relationship between AF and noncardioembolic stroke subtypes are unclear. Because…”
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Genetically Encoded Detection of Biosynthetic Protease Inhibitors by Kramer, Levi, Sarkar, Ankur, Foderaro, Tom, Markley, Andrew L., Lee, Jessica, Edstrom, Hannah, Sharma, Shajesh, Gill, Eden, Traylor, Matthew J., Fox, Jerome M.

“…Proteases are an important class of drug targets that continue to drive inhibitor discovery. These enzymes are prone to resistance mutations, yet their promise…”
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Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study by Larsson, Susanna C, Traylor, Matthew, Markus, Hugh S

“…Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian…”
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Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study by Traylor, Matthew, Curtis, Charles, Patel, Hamel, Breen, Gerome, Hyuck Lee, Sang, Xu, Xiaohui, Newhouse, Stephen, Dobson, Richard, Steer, Sophia, Cope, Andrew P, Markus, Hugh S, Lewis, Cathryn M, Scott, Ian C

“…To evaluate whether genetic and environmental factors associated with RA in European and Asian ancestry populations are also associated with RA in African…”
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Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: Purification, activity, and binding properties toward multiple pesticides by Cheesman, Matthew J., Traylor, Matthew J., Hilton, Margaret E., Richards, Katelyn E., Taylor, Matthew C., Daborn, Phillip J., Russell, Robyn J., Gillam, Elizabeth M.J., Oakeshott, John G.

“…Cytochrome P450 CYP6G1 has been implicated in the resistance of Drosophila melanogaster to numerous pesticides. While in vivo and in vitro studies have…”
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Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases by Traylor, Matthew, Knevel, Rachel, Cui, Jing, Taylor, John, Harm-Jan, Westra, Conaghan, Philip G, Cope, Andrew P, Curtis, Charles, Emery, Paul, Newhouse, Stephen, Patel, Hamel, Steer, Sophia, Gregersen, Peter, Shadick, Nancy A, Weinblatt, Michael E, Van Der Helm-van Mil, Annette, Barrett, Jennifer H, Morgan, Ann W, Lewis, Cathryn M, Scott, Ian C

“…Previous studies of radiological damage in rheumatoid arthritis (RA) have used candidate-gene approaches, or evaluated single genome-wide association studies…”
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Genetically Determined Levels of Circulating Cytokines and Risk of Stroke by Georgakis, Marios K, Gill, Dipender, Rannikmäe, Kristiina, Traylor, Matthew, Anderson, Christopher D, Lee, Jin-Moo, Kamatani, Yoichiro, Hopewell, Jemma C, Worrall, Bradford B, Bernhagen, Jürgen, Sudlow, Cathie L M, Malik, Rainer, Dichgans, Martin

“…Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their…”
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Recombinant expression and characterization of Lucilia cuprina CYP6G3: Activity and binding properties toward multiple pesticides by Traylor, Matthew J., Baek, Jong-Min, Richards, Katelyn E., Fusetto, Roberto, Huang, W., Josh, Peter, Chen, Zhenzhong, Bollapragada, Padma, O'Hair, Richard A.J., Batterham, Philip, Gillam, Elizabeth M.J.

“…The Australian sheep blowfly, Lucilia cuprina, is a primary cause of sheep flystrike and a major agricultural pest. Cytochrome P450 enzymes have been…”
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