Search Results - "Traves, Suzanne"

Th17 cells in airway diseases by Traves, Suzanne L, Donnelly, Louise E

“…Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the…”
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Chemokine release from human rhinovirus–infected airway epithelial cells promotes fibroblast migration by Shelfoon, Christopher, BSc, Shariff, Sami, BSc, Traves, Suzanne L., PhD, Kooi, Cora, PhD, Leigh, Richard, MD, PhD, Proud, David, PhD

“…Background Thickening of the lamina reticularis, a feature of remodeling in the asthmatic airways, is now known to be present in young children who wheeze…”
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Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD by Arnason, Jason W, Murphy, James C, Kooi, Cora, Wiehler, Shahina, Traves, Suzanne L, Shelfoon, Christopher, Maciejewski, Barbara, Dumonceaux, Curtis J, Lewenza, W Shawn, Proud, David, Leigh, Richard

“…Viral-bacterial co-infections are associated with severe exacerbations of COPD. Epithelial antimicrobial peptides, including human β-defensin-2 (HBD-2), are…”
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Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD by Costa, Claudia, Traves, Suzanne L, Tudhope, Susan J, Fenwick, Peter S, Belchamber, Kylie B R, Russell, Richard E K, Barnes, Peter J, Donnelly, Louise E

“…Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in the lung parenchyma and the airways, which is characterised by an…”
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Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration by Shariff, Sami, Shelfoon, Christopher, Holden, Neil S, Traves, Suzanne L, Wiehler, Shahina, Kooi, Cora, Proud, David, Leigh, Richard

“…Airway remodeling, a characteristic feature of asthma, begins in early life. Recurrent human rhinovirus (HRV) infections are a potential inciting stimulus for…”
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Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33 by Mehta, Amit K., PhD, Duan, Wei, PhD, Doerner, Astrid M., PhD, Traves, Suzanne L., PhD, Broide, David H., MB, ChB, Proud, David, PhD, Zuraw, Bruce L., MD, Croft, Michael, PhD

“…Background Rhinovirus infection at an early age has been associated with development of asthma, but how rhinovirus influences the immune response is not clear…”
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Rhinovirus and Bacteria Synergistically Induce IL-17C Release from Human Airway Epithelial Cells To Promote Neutrophil Recruitment by Jamieson, Kyla C, Traves, Suzanne L, Kooi, Cora, Wiehler, Shahina, Dumonceaux, Curtis J, Maciejewski, Barbara A, Arnason, Jason W, Michi, Aubrey N, Leigh, Richard, Proud, David

“…Virus-bacteria coinfections are associated with more severe exacerbations and increased risk of hospital readmission in patients with chronic obstructive…”
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Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells by Mostafa, Mahmoud M, Rider, Christopher F, Shah, Suharsh, Traves, Suzanne L, Gordon, Paul M K, Miller-Larsson, Anna, Leigh, Richard, Newton, Robert

“…Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment…”
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Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes by Proud, David, Hudy, Magdalena H, Wiehler, Shahina, Zaheer, Raza S, Amin, Minaa A, Pelikan, Jonathan B, Tacon, Claire E, Tonsaker, Tabitha O, Walker, Brandie L, Kooi, Cora, Traves, Suzanne L, Leigh, Richard

“…Human rhinovirus (HRV) infections trigger acute exacerbations of chronic obstructive pulmonary disease (COPD) and asthma. The human airway epithelial cell is…”
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Transcriptional and epigenetic modulation of human rhinovirus-induced CXCL10 production by cigarette smoke by Hudy, Magdalena H, Traves, Suzanne L, Proud, David

“…Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the…”
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CXCR3 and CCR5 chemokines in induced sputum from patients with COPD by Costa, Claudia, Rufino, Rogerio, Traves, Suzanne L, Lapa E Silva, Jose Roberto, Barnes, Peter J, Donnelly, Louise E

“…COPD is associated with increased numbers of CD4(+) and CD8(+) lymphocytes and macrophages in the small airways and lung parenchyma. The chemokines regulating…”
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Rhinovirus-bacteria coexposure synergistically induces CCL20 production from human bronchial epithelial cells by Maciejewski, Barbara A, Jamieson, Kyla C, Arnason, Jason W, Kooi, Cora, Wiehler, Shahina, Traves, Suzanne L, Leigh, Richard, Proud, David

“…Exacerbations of chronic obstructive pulmonary disease are triggered by viral or bacterial pathogens, with human rhinovirus (HRV) and nontypeable (NTHI) among…”
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Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS by Shah, Suharsh, Mostafa, Mahmoud M, McWhae, Andrew, Traves, Suzanne L, Newton, Robert

“…TNF is central to inflammation and may play a role in the pathogenesis of asthma. The 3'-untranslated region of the TNF transcript contains AU-rich elements…”
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Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2 by Traves, Suzanne L., Smith, Susan J., Barnes, Peter J., Donnelly, Louise E.

“…Leukocyte migration is critical to maintaining host defense, but uncontrolled cellular infiltration into tissues can lead to chronic inflammation. In the lung,…”
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Effect of incremental exercise on airway and systemic inflammation in patients with COPD by Davidson, Warren J, Verity, Wendy S, Traves, Suzanne L, Leigh, Richard, Ford, Gordon T, Eves, Neil D

“…Airway and systemic inflammation are features of chronic obstructive pulmonary disease (COPD), and there is growing interest in clarifying the inflammatory…”
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An inhaled dose of budesonide induces genes involved in transcription and signaling in the human airways: enhancement of anti‐ and proinflammatory effector genes by Leigh, Richard, Mostafa, Mahmoud M., King, Elizabeth M., Rider, Christopher F., Shah, Suharsh, Dumonceaux, Curtis, Traves, Suzanne L., McWhae, Andrew, Kolisnik, Tyler, Kooi, Cora, Slater, Donna M., Kelly, Margaret M., Bieda, Mark, Miller‐Larsson, Anna, Newton, Robert

“…Although inhaled glucocorticoids, or corticosteroids (ICS), are generally effective in asthma, understanding their anti‐inflammatory actions in vivo remains…”
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Viral-associated exacerbations of asthma and COPD by Traves, Suzanne L, Proud, David

“…Exacerbations of asthma and chronic obstructive pulmonary disease are major burdens on the healthcare system, and contribute significantly to the mortality and…”
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Selective Prostacyclin Receptor Agonism Augments Glucocorticoid-Induced Gene Expression in Human Bronchial Epithelial Cells by Wilson, Sylvia M, Shen, Pamela, Rider, Christopher F, Traves, Suzanne L, Proud, David, Newton, Robert, Giembycz, Mark A

“…Prostacyclin receptor (IP-receptor) agonists display anti-inflammatory and antiviral activity in cell-based assays and in preclinical models of asthma and…”
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4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release by Ayer, Linda M, Wilson, Sylvia M, Traves, Suzanne L, Proud, David, Giembycz, Mark A

“…The extent to which the prostacyclin (IP) receptor regulates the release of two proinflammatory chemokines from human airway epithelial cells was investigated…”
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Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1) by Shah, Suharsh, Mostafa, Mahmoud M., McWhae, Andrew, Traves, Suzanne L., Newton, Robert

“…TNF is central to inflammation and may play a role in the pathogenesis of asthma. The 3′-untranslated region of the TNF transcript contains AU-rich elements…”
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