Search Results - "Travé, G."
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A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells
Published in Oncogene (05-02-2009)“…High-risk mucosal human papillomaviruses (HPV), mainly HPV16 and HPV18, are implicated in cervical carcinogenesis. HPV16 E6 oncoprotein binds and often targets…”
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Formation of Soluble Inclusion Bodies by HPV E6 Oncoprotein Fused to Maltose-Binding Protein
Published in Protein expression and purification (01-10-2001)“…Many polypeptides overexpressed in bacteria are produced misfolded and accumulate as solid structures called inclusion bodies. Inclusion-body-prone proteins…”
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Use of Reclaimed Geomembranes for Modification of Mechanical Performance of Bituminous Binders
Published in Journal of materials in civil engineering (01-07-2016)“…AbstractThe use of modified binders plays a very important role in the construction of more durable pavements. However, the addition of modifiers to the…”
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A strategy for optimizing the monodispersity of fusion proteins: application to purification of recombinant HPV E6 oncoprotein
Published in Protein engineering (01-04-2001)“…Recombinant production of HPV oncoprotein E6 is notoriously difficult. The unfused sequence is produced in inclusion bodies. By contrast, fusions of E6 to the…”
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NMR in the SPINE Structural Proteomics project
Published in Acta crystallographica. Section D, Biological crystallography. (01-10-2006)“…This paper describes the developments, role and contributions of the NMR spectroscopy groups in the Structural Proteomics In Europe (SPINE) consortium…”
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Analysing industrial manufacturing in-plant and in-service performance of asphalt mixtures cleaner technologies
Published in Journal of cleaner production (10-05-2016)“…Roads play a significant role in the development of societies. Considerable quantities of asphalt mixes are employed in their construction, with hot asphalt…”
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Mechanical Performance of SMA Mixtures Manufactured with Reclaimed Geomembrane–Modified Binders
Published in Journal of materials in civil engineering (01-02-2018)“…AbstractGiven the high costs associated with using polymer-modified bitumen in asphalt pavement for roads, this research set out to develop more competitive…”
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Specific recognition of four-way DNA junctions by the C-terminal zinc-binding domain of HPV oncoprotein E6
Published in Journal of molecular biology (26-01-2001)“…E6 is an oncoprotein implicated in cervical cancers produced by “ high risk “ human papillomaviruses. E6 binds specifically to several cellular proteins,…”
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Molecular mechanism of the calcium‐induced conformational change in the spectrin EF‐hands
Published in The EMBO journal (16-10-1995)“…Calcium is a universally employed cytosolic messenger in eukaryotic cells. Most of the proteins that bind signalling calcium are members of the calmodulin…”
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Comparison of the effect of recycled crumb rubber and polymer concentration on the performance of binders for asphalt mixtures
Published in Materiales de construcción (Madrid) (01-07-2016)“…Crumb rubber modified binders are environmental-friendly alternatives to polymer modified bitumens in asphalt mixtures. This paper compares the performance of…”
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HPV oncoprotein E6 is a structure-dependent DNA-binding protein that recognizes four-way junctions
Published in Journal of molecular biology (10-03-2000)“…E6 is an oncoprotein implicated in cervical cancers, produced by "high-risk" human papillomaviruses. E6 is thought to promote tumorigenesis by stimulating…”
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Evaluating the mechanical performance of Very Thin Asphalt Overlay (VTAO) as a sustainable rehabilitation strategy in urban pavements
Published in Materiales de construcción (Madrid) (01-07-2017)“…Very Thin Asphalt Overlay (VTAO) has been introduced as an alternative to traditional thick overlays, seal coats, and micro-surfacings. Nonetheless, there are…”
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Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated Pathogenesis
Published in Molecular cell (03-03-2006)“…Oncoprotein E6 is essential for oncogenesis induced by human papillomaviruses (HPVs). The solution structure of HPV16-E6 C-terminal domain reveals a zinc…”
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Kinetic Analysis of the Interactions of Human Papillomavirus E6 Oncoproteins with the Ubiquitin Ligase E6AP Using Surface Plasmon Resonance
Published in Journal of molecular biology (03-06-2005)“…Cervical cancers evolve from lesions generated by genital human papillomaviruses (HPV). “Low-risk” genital HPVs cause benign proliferations whereas “high-risk”…”
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Fatigue cracking in asphalt mixtures: the effects of ageing and temperature
Published in Road materials and pavement design (03-04-2018)“…Bituminous mixtures are viscoelastic materials whose mechanical performance is highly influenced by temperature. In addition, during their service life, these…”
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Inhibition of human immunodeficiency virus infection by the lectin jacalin and by a derived peptide showing a sequence similarity with gp120
Published in European journal of immunology (01-01-1993)“…Jacalin is a plant lectin known to specifically induce the proliferation of CD4+ T lymphocytes in human. We demonstrate here that jacalin completely blocks…”
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Evaluación del comportamiento mecánico de capas bituminosas ultra delgadas como una adecuada estrategia para la rehabilitación de pavimentos urbanos
Published in Materiales de construcción (Madrid) (26-07-2017)“…Very Thin Asphalt Overlay (VTAO) has been introduced as an alternative to traditional thick overlays, seal coats, and micro-surfacings. Nonetheless, there are…”
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Site-directed mutagenesis of a calcium binding site modifies specifically the different biochemical properties of annexin I
Published in Protein engineering (01-05-1994)“…All the functions of annexins in vitro as well as in vivo are mediated and probably regulated by calcium. We have used recombinant annexin I, synthesized by…”
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The C‐Terminal Domain of α‐Spectrin is Structurally Related to Calmodulin
Published in European journal of biochemistry (01-01-1995)“…An alignment of amino acid sequences suggests that the spectrin domain, which contains two EF‐hand calcium‐binding motifs, is structurally related to…”
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