Search Results - "Trauzold, A"

Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2 by Bertsch, U, Röder, C, Kalthoff, H, Trauzold, A

“…Localized in the plasma membrane, death domain-containing TNF-related apoptosis-inducing ligand (TRAIL) receptors, TRAIL-R1 and TRAIL-R2, induce apoptosis and…”
Get full text

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation by Heinrich, M, Neumeyer, J, Jakob, M, Hallas, C, Tchikov, V, Winoto-Morbach, S, Wickel, M, Schneider-Brachert, W, Trauzold, A, Hethke, A, Schütze, S

“…Acidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these proteases and the acidic endolysosomal…”
Get full text

Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo by Brockschmidt, C, Hirner, H, Huber, N, Eismann, T, Hillenbrand, A, Giamas, G, Radunsky, B, Ammerpohl, O, Bohm, B, Henne-Bruns, D, Kalthoff, H, Leithäuser, F, Trauzold, A, Knippschild, U

“…Pancreatic ductal adenocarcinomas (PDACs) are highly resistant to treatment due to changes in various signalling pathways. CK1 isoforms play important…”
Get more information

In silico analysis of the transportome in human pancreatic ductal adenocarcinoma by Zaccagnino, A., Pilarsky, C., Tawfik, D., Sebens, S., Trauzold, A., Novak, I., Schwab, A., Kalthoff, H.

“…The altered expression and/or activity of ion channels and transporters (transportome) have been associated with malignant behavior of cancer cells and were…”
Get full text

c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells by Geismann, C, Grohmann, F, Sebens, S, Wirths, G, Dreher, A, Häsler, R, Rosenstiel, P, Hauser, C, Egberts, J-H, Trauzold, A, Schneider, G, Sipos, B, Zeissig, S, Schreiber, S, Schäfer, H, Arlt, A

“…Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-…”
Get full text

c-Rel is a critical mediator of NF-[kappa]B-dependent TRAIL resistance of pancreatic cancer cells by Geismann, C, Grohmann, F, Sebens, S, Wirths, G, Dreher, A, Häsler, R, Rosenstiel, P, Hauser, C, Egberts, J-h, Trauzold, A, Schneider, G, Sipos, B, Zeissig, S, Schreiber, S, Schäfer, H, Arlt, A

“…Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies…”
Get full text

Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo by Alsadeq, A, Strube, S, Krause, S, Carlet, M, Jeremias, I, Vokuhl, C, Loges, S, Aguirre-Ghiso, J A, Trauzold, A, Cario, G, Stanulla, M, Schrappe, M, Schewe, D M

“…P38α/β has been described as a tumor-suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However, p38α/β also regulates…”
Get full text

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation by Ehrenschwender, M, Siegmund, D, Wicovsky, A, Kracht, M, Dittrich-Breiholz, O, Spindler, V, Waschke, J, Kalthoff, H, Trauzold, A, Wajant, H

“…Constitutively active PI3K catalytic subunit α ( PIK3CA ) interfered with apoptosis induction downstream of death receptor-signaling complex formation allowing…”
Get full text

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells by AMMERPOHL, O, TRAUZOLD, A, KALTHOFF, H, SCHNIEWIND, B, GRIEP, U, PILARSKY, C, GRUTZMANN, R, SAEGER, H.-D, JANSSEN, O, SIPOS, B, KLOPPEL, G

“…Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease and one of the cancer entities with the lowest life expectancy. Beside surgical therapy, no…”
Get full text

TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma by Trauzold, A, Siegmund, D, Schniewind, B, Sipos, B, Egberts, J, Zorenkov, D, Emme, D, Röder, C, Kalthoff, H, Wajant, H

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention for its potential use in tumor therapy, as some…”
Get full text

Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells by TRAUZOLD, A, SCHMIEDEL, S, KALTHOFF, H, RÖDER, C, TAMS, C, CHRISTGEN, M, OESTERN, S, ARLT, A, WESTPHAL, S, KAPISCHKE, M, UNGEFROREN, H

“…Inability to die by apoptosis is one of the reasons for the deregulated growth of tumour cells and the frequently observed failure of chemotherapy. In this…”
Get full text

FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis by Ungefroren, H, Kruse, M L, Trauzold, A, Roeschmann, S, Roeder, C, Arlt, A, Henne-Bruns, D, Kalthoff, H

“…In this study we investigated the functional role of FAP-1 as a potential inhibitor of CD95 (Fas, APO-1)-mediated apoptosis in pancreatic cancer cells. Stable…”
Get full text

Plasticity- and neurodegeneration-linked cyclic-AMP responsive element modulator/inducible cyclic-AMP early repressor messenger RNA expression in the rat brain by Konopka, D, Szklarczyk, A.W, Filipkowski, R.K, Trauzold, A, Nowicka, D, Hetman, M, Kaczmarek, L

“…In order to explore the role of CREM (cyclic-AMP responsive element modulator) gene expression in the function of the central nervous system, the gene…”
Get full text

243 Penile cancer cell lines of primary tumors and lymph node metastases are resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cell death by Naumann, C.M, Hamann, M.F, Van Der Horst, C, Colberg, C, Osmonov, D, Engelmann, D, Jünemann, K.P, Kalthoff, H, Trauzold, A

Get full text

Effects of p38[alpha]/[beta] inhibition on acute lymphoblastic leukemia proliferation and survival in vivo by Loges, S, Vokuhl, C, Strube, S, Alsadeq, A, Krause, S, Carlet, M, Jeremias, I

“…P38[alpha]/[beta] has been described as a tumor-suppressor controlling cell cycle checkpoints and senescence in epithelial malignancies. However,…”
Get full text

Dasatinib treatment results in a markedly diminished frequency of bone metastases after intracardiac injection of osteotropic MDA-MB-231 breast cancer cells in a xenograft mouse model by Heilmann, T, Roscher, M, Rumpf, AL, Gerle, M, Tietgen, M, Will, O, Damm, T, Maass, N, Glüer, CC, Tiwari, S, Trauzold, A, Schem, C

“…Abstract only…”
Get full text

CD95 and TRAF2 promote invasiveness of pancreatic cancer cells by Trauzold, Anna, Röder, Christian, Sipos, Bence, Karsten, Kristin, Arlt, Alexander, Jiang, Ping, Martin-Subero, Jose Ignacio, Siegmund, Daniela, Můerköster, Susanne, Pagerols-Raluy, Laia, Siebert, Reiner, Wajant, Harald, Kalthoff, Holger

“…ABSTRACT Pancreatic adenocarcinoma represents a tumor type with extremely poor prognosis. High apoptosis resistance and a strong invasive and early metastatic…”
Get full text

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells by Trauzold, Anna, Wermann, Hendrik, Arlt, Alexander, Schutze, Stefan, Schafer, Heiner, Oestern, Stefanie, Roder, Christian, Ungefroren, Hendrik, Lampe, Esther, Heinrich, Michael, Walczak, Henning, Kalthoff, Holger

“…The molecular alterations in tumour cells leading to resistance towards apoptosis induced by CD95 and TRAIL-receptors are not fully understood. We report here…”
Get full text

PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells by Trauzold, Anna, Schmiedel, Stefan, Sipos, Bence, Wermann, Hendrik, Westphal, Sabine, Roder, Christian, Klapper, Wolfram, Arlt, Alexander, Lehnert, Lasse, Ungefroren, Hendrik, Johannes, Franz-Josef, Kalthoff, Holger

“…Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown…”
Get full text

Knockdown of TRAIL-R2 in breast cancer cells impairs bone metastases formation in a preclinical mouse model by Heilmann, T, Fritsche, H, Towers, R, Campbell, G, Rauner, M, Hauser, C, Tiwari, S, Jonat, W, Schem, C, Kalthoff, H, Trauzold, A

“…Abstract only…”
Get full text