Search Results - "Trauger, J W"

Regulation of gene expression by small molecules by Gottesfeld, Joel M, Neely, Laura, Trauger, John W, Baird, Eldon E, Dervan, Peter B

“…Small molecules that target specific DNA sequences have the potential to control gene expression. Ligands designed for therapeutic application must bind any…”
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Generality of Peptide Cyclization Catalyzed by Isolated Thioesterase Domains of Nonribosomal Peptide Synthetases by Kohli, Rahul M, Trauger, John W, Schwarzer, Dirk, Marahiel, Mohamed A, Walsh, Christopher T

“…The C-terminal thioesterase (TE) domains from nonribosomal peptide synthetases (NRPSs) catalyze the final step in the biosynthesis of diverse biologically…”
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Footprinting methods for analysis of pyrrole-imidazole polyamide/DNA complexes by Trauger, J W, Dervan, P B

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Cyclization of Backbone-Substituted Peptides Catalyzed by the Thioesterase Domain from the Tyrocidine Nonribosomal Peptide Synthetase by Trauger, John W, Kohli, Rahul M, Walsh, Christopher T

“…The excised C-terminal thioesterase (TE) domain from the multidomain tyrocidine nonribosomal peptide synthetase (NRPS) was recently shown to catalyze…”
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Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase by Walsh, Christopher T, Trauger, John W, Kohli, Rahul M, Mootz, Henning D, Marahiel, Mohamed A

“…In the biosynthesis of many macrocyclic natural products by multidomain megasynthases, a carboxy-terminal thioesterase (TE) domain is involved in cyclization…”
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Recognition of DNA by designed ligands at subnanomolar concentrations by Trauger, J W, Baird, E E, Dervan, P B

“…Small molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome would be useful tools in molecular biology and…”
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Inhibition of RNA Polymerase II Transcription in Human Cells by Synthetic DNA-Binding Ligands by Dickinson, Liliane A., Gulizia, Richard J., Trauger, John W., Baird, Eldon E., Mosier, Donald E., Gottesfeld, Joel M., Dervan, Peter B.

“…Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular…”
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Recognition of DNA by designed ligands at subnanomolar concentrations by Trauger, John W, Baird, Eldon E, Dervan, Peter B

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Heterologous expression in Escherichia coli of the first module of the nonribosomal peptide synthetase for chloroeremomycin, a vancomycin-type glycopeptide antibiotic by Trauger, J W, Walsh, C T

“…The gene cluster from Amycolotopsis orientalis responsible for biosynthesis of the vancomycin-type glycopeptide antibiotic chloroeremomycin was recently…”
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Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer by Trauger, John W, Baird, Eldon E, Dervan, Peter B

“…Cell-permeable small molecules that bind predetermined DNA sequences with affinities and specificities comparable to those of natural DNA-binding proteins have…”
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Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-κB, and DNA by a Designed DNA-binding Ligand by Dickinson, Liliane A., Trauger, John W., Baird, Eldon E., Dervan, Peter B., Graves, Barbara J., Gottesfeld, Joel M.

“…Sequence-specific pyrrole-imidazole polyamides can be designed to interfere with transcription factor binding and to regulate gene expression, both in vitro…”
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Chain Termination Steps in Nonribosomal Peptide Synthetase Assembly Lines: Directed Acyl-S-Enzyme Breakdown in Antibiotic and Siderophore Biosynthesis by Keating, Thomas A., Ehmann, David E., Kohli, Rahul M., Marshall, C. Gary, Trauger, John W., Walsh, Christopher T.

“…The multidomain enzymes that biosynthesize important natural peptide products such as cyclosporin and vancomycin carry the growing biopolymer chains covalently…”
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Extension of Sequence-Specific Recognition in the Minor Groove of DNA by Pyrrole−Imidazole Polyamides to 9−13 Base Pairs by Trauger, John W, Baird, Eldon E, Mrksich, Milan, Dervan, Peter B

“…The sequence-specific recognition of the minor groove of DNA by pyrrole−imidazole polyamides has been extended to 9−13 base pairs (bp). Four polyamides,…”
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Anti-repression of RNA Polymerase II Transcription by Pyrrole−Imidazole Polyamides by Dickinson, Liliane A, Trauger, John W, Baird, Eldon E, Ghazal, Peter, Dervan, Peter B, Gottesfeld, Joel M

“…Pyrrole−imidazole polyamides are ligands that bind in the minor groove of DNA with high affinity and sequence selectivity. Molecules of this class have been…”
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Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex by Neely, Laura, Trauger, John W., Baird, Eldon E., Dervan, Peter B., Gottesfeld, Joel M.

“…The gene-specific transcription factor IIIA (TFIIIA) binds to the internal promoter element of the 5 S rRNA gene through nine zinc fingers which make specific…”
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Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand by McBryant, S J, Baird, E E, Trauger, J W, Dervan, P B, Gottesfeld, J M

“…Transcription factor IIIB (TFIIIB) is composed of the TATA box binding protein (TBP) and class III gene-specific TBP-associated factors (TAFs). TFIIIB is…”
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Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity by Kraus, Richard L., Pasieczny, Rodger, Lariosa‐Willingham, Karen, Turner, Mary S., Jiang, Alice, Trauger, John W.

“…Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti‐inflammatory and anti‐apoptotic…”
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Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases by Ehmann, David E, Trauger, John W, Stachelhaus, Torsten, Walsh, Christopher T

“…Background: Nonribosomal peptide synthetases (NRPSs) are large multidomain proteins that catalyze the formation of a wide range of biologically active natural…”
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Heterologous Expression in Escherichia coli of the First Module of the Nonribosomal Peptide Synthetase for Chloroeremomycin, a Vancomycin-Type Glycopeptide Antibiotic by Trauger, John W., Walsh, Christopher T.

“…The gene cluster from Amycolotopsis orientalis responsible for biosynthesis of the vancomycin-type glycopeptide antibiotic chloroeremomycin was recently…”
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Kinetics of Allopregnanolone Formation Catalyzed by Human 3α-Hydroxysteroid Dehydrogenase Type III (AKR1C2) by Trauger, John W, Jiang, Alice, Stearns, Brian A, LoGrasso, Philip V

“…Allopregnanolone is a neurosteroid which exhibits anxiolytic and anticonvulsant activities through potentiation of the GABAA receptor. The reduction of…”
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