Search Results - "Trasi, Niraj S."

Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs-Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products by Trasi, Niraj S, Taylor, Lynne S

“…There is increasing interest in formulating combination products that contain two or more drugs. Furthermore, it is also common for different drug products to…”
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Impact of surfactants on the crystal growth of amorphous celecoxib by Mosquera-Giraldo, Laura I., Trasi, Niraj S., Taylor, Lynne S.

“…The purpose of this study was to investigate the impact of surfactants on the rate of crystal growth of amorphous celecoxib, both in the presence and absence…”
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Non-Sink Dissolution Behavior and Solubility Limit of Commercial Tacrolimus Amorphous Formulations by Trasi, Niraj S, Purohit, Hitesh S, Wen, Hong, Sun, Dajun D, Taylor, Lynne S

“…An increasing number of drugs with low aqueous solubility are being formulated and marketed as amorphous solid dispersions because the amorphous form can…”
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Amorphous solid dispersion formation via solvent granulation – A case study with ritonavir and lopinavir by Trasi, Niraj S., Bhujbal, Sonal, Zhou, Qi Tony, Taylor, Lynne S.

“…[Display omitted] Herein, we evaluate the potential of using a simple solvent granulation process to prepare a binary drug amorphous solid dispersion (ASD)…”
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Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach by Trasi, Niraj S., Bhujbal, Sonal V., Zemlyanov, Dmitry Y., Zhou, Qi (Tony), Taylor, Lynne S.

“…Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility, have been shown to improve bioavailability relative to crystalline…”
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Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion by Bhardwaj, Vivekanand, Trasi, Niraj S., Zemlyanov, Dmitry Y., Taylor, Lynne S.

“…[Display omitted] Amorphous solid dispersions of itraconazole (ITZ) and copovidone (PVPVA 64) at 1:1 to 1:9 drug-polymer ratios were prepared using…”
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Dissolution performance of binary amorphous drug combinations—Impact of a second drug on the maximum achievable supersaturation by Trasi, Niraj S., Taylor, Lynne S.

“…[Display omitted] An increased number of amorphous formulations of poorly water soluble drugs are being introduced into the market due to their higher…”
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Evaluation of the Crystallization Tendency of Commercially Available Amorphous Tacrolimus Formulations Exposed to Different Stress Conditions by Trasi, Niraj S., Purohit, Hitesh S., Taylor, Lynne S.

“…Purpose Tacrolimus, an immunosuppressant, is a poorly water soluble compound whereby the commercially available capsule formulations contain the drug in…”
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Factors Influencing Crystal Growth Rates from Undercooled Liquids of Pharmaceutical Compounds by Trasi, Niraj S, Baird, Jared A, Kestur, Umesh S, Taylor, Lynne S

“…Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of…”
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Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide by Trasi, Niraj S, Taylor, Lynne S

“…Understanding the effect of polymers on the crystallization behavior of low molecular weight organic compounds is important to a number of areas. Since…”
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Mechanically Induced Amorphization of Drugs: A Study of the Thermal Behavior of Cryomilled Compounds by Trasi, Niraj S., Byrn, Stephen R.

“…The purpose of this work was to determine what aspect of the milled compound influences its thermal profile. For this, six different compounds with different…”
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Nilutamide by Trasi, Niraj S, Fanwick, Phillip E, Taylor, Lynne S

“…THE CRYSTAL STRUCTURE OF NILUTAMIDE [SYSTEMATIC NAME: 5,5-dimethyl-3-[4-nitro-3-(trifluoro-meth-yl)phen-yl]imidazolidine-2,4-dione], C(12)H(10)F(3)N(3)O(4),…”
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Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations by Purohit, Hitesh S, Trasi, Niraj S, Osterling, Donald J, Stolarik, Deanne F, Jenkins, Gary J, Gao, Wenqing, Zhang, Geoff G. Z, Taylor, Lynne S

“…Crystallization of drug from an amorphous formulation is expected to negatively impact its bioperformance following oral delivery. In evaluating this in vivo,…”
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Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions by Correa-Soto, Clara, Trasi, Niraj S., Schmitt, Paul D., Su, Yongchao, Liu, Zhen, Miller, Elise, Variankaval, Narayan, Marsac, Patrick J., Simpson, Garth J., Taylor, Lynne S.

“…•Second harmonic generation (SHG) microscopy was applied for sensitive detection of crystallinity in spray dried particles.•SHG detected crystallinity at an…”
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Finding the Needle in the Haystack: Characterization of Trace Crystallinity in a Commercial Formulation of Paclitaxel Protein-Bound Particles by Raman Spectroscopy Enabled by Second Harmonic Generation Microscopy by Schmitt, Paul D, Trasi, Niraj S, Taylor, Lynne S, Simpson, Garth J

“…Second harmonic generation (SHG) microscopy was used to rapidly identify regions of interest for localized confocal Raman spectroscopy measurements in order to…”
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Investigation of the Milling-Induced Thermal Behavior of Crystalline and Amorphous Griseofulvin by Trasi, Niraj S, Boerrigter, Stephan X. M, Byrn, Stephen Robert

“…Purpose To gain a better understanding of the physical state and the unusual thermal behavior of milled griseofulvin. Methods Griseofulvin crystals and…”
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Ab Initio Prediction of the Diversity of Second Harmonic Generation from Pharmaceutically Relevant Materials by Toth, Scott J, Schmitt, Paul D, Snyder, Greg R, Trasi, Niraj S, Sullivan, Shane Z, George, Irene A, Taylor, Lynne S, Simpson, Garth J

“…A model for predicting the anticipated second harmonic generation (SHG) activity of crystalline active pharmaceutical ingredients (APIs) was developed based on…”
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Investigating the effect of dehydration conditions on the compactability of glucose by Trasi, Niraj S., Boerrigter, Stephan X.M., Byrn, Stephen R., Carvajal, Teresa M.

“…Hydrates are commonly found in pharmaceutical ingredients either in excipients or in the active pharmaceutical ingredient form. There is always the possibility…”
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