Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146

Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146

CD146, also known as melanoma cell adhesion molecule or MCAM, is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis. CD146 promotes tumor progression of many cancers including melanoma and prostate. Strikingly, its expression is frequently lost in breast carcinoma cel...

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Bibliographic Details
Published in:Biochimica et biophysica acta Vol. 1795; no. 2; pp. 130 - 136
Main Authors: Ouhtit, Allal, Gaur, Rajiv L., Abd Elmageed, Zakaria Y., Fernando, Augusta, Thouta, Rajesh, Trappey, Alison K., Abdraboh, Mohamed E., El-Sayyad, Hassan I., Rao, Prakash, Raj, Madhwa G.H.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-04-2009
Subjects:
Angiogenesis
Animals
Breast cancer
Breast Neoplasms - etiology
CD146
CD146 Antigen - chemistry
CD146 Antigen - physiology
Endothelial Cells - physiology
Female
Humans
Male
Melanoma - etiology
Prostatic Neoplasms - etiology
Signal transduction
Signal Transduction - physiology
Tumor suppressor
Angiogenesis
Signal transduction
Breast cancer
CD146
Tumor suppressor
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Summary:CD146, also known as melanoma cell adhesion molecule or MCAM, is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis. CD146 promotes tumor progression of many cancers including melanoma and prostate. Strikingly, its expression is frequently lost in breast carcinoma cells, and it may act as a suppressor of breast cancer progression. While upstream mechanisms regulating CD146 are well documented, our understanding of the downstream molecular events underlying its mode of action remains to be elucidated. This review aims to focus on the progress in understanding the signaling mechanisms and the functional relevance of CD146, a multifaceted molecule, in cancer with particular emphasis on its role in inhibiting breast cancer progression.
ISSN:0304-419X
0006-3002
1879-2561
DOI:10.1016/j.bbcan.2009.01.002