Search Results - "Trapella, C"

JWH-018 impairs sensorimotor functions in mice by Ossato, A, Vigolo, A, Trapella, C, Seri, C, Rimondo, C, Serpelloni, G, Marti, M

“…Highlights • JWH-018 impairs sensorimotor responses in mice by stimulation of CB1 receptors. • JWH-018 reduces more powerfully than Δ9 -THC sensorimotor…”
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Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice by Vigolo, A., Ossato, A., Trapella, C., Vincenzi, F., Rimondo, C., Seri, C., Varani, K., Serpelloni, G., Marti, M.

“…JWH-018 is a synthetic CB1 and CB2 agonist illegally marketed as products named “Spice” or “herbal blend” for its psychoactive effects which are much higher…”
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Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2 by Malfacini, D, Ambrosio, C, Gro', M C, Sbraccia, M, Trapella, C, Guerrini, R, Bonora, M, Pinton, P, Costa, T, Calo', G

“…Nociceptin/orphanin FQ (N/OFQ) controls several biological functions by selectively activating an opioid like receptor named N/OFQ peptide receptor (NOP)…”
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Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin test by Rizzi, A., Ruzza, C., Bianco, S., Trapella, C., Calo’, G.

“…•Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions, including pain.•NOP(-/-) mice displayed a pronociceptive phenotype in the orofacial…”
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Synthetic cannabinoid JWH-018 and its halogenated derivatives JWH-018-Cl and JWH-018-Br impair Novel Object Recognition in mice: Behavioral, electrophysiological and neurochemical evidence by Barbieri, M., Ossato, A., Canazza, I., Trapella, C., Borelli, A.C., Beggiato, S., Rimondo, C., Serpelloni, G., Ferraro, L., Marti, M.

“…It is well known that an impairment of learning and memory function is one of the major physiological effects caused by natural or synthetic cannabinoid…”
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New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting by Rondanin, R., Lettini, G., Oliva, P., Baruchello, R., Costantini, C., Trapella, C., Simoni, D., Bernardi, T., Sisinni, L., Pietrafesa, M., Ponterini, G., Costi, M.P., Vignudelli, T., Luciani, R., Matassa, D.S., Esposito, F., Landriscina, M.

“…[Display omitted] •Analogues of known Hsp90 inhibitors with a permanent or ionizable cationic head.•Inhibition of TRAP1 ATPase activity and detection in…”
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Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands by Bird, M.F., Vardanyan, R.S., Hruby, V.J., Calò, G., Guerrini, R., Salvadori, S., Trapella, C., McDonald, J., Rowbotham, D.J., Lambert, D.G.

“…Opioid tolerance is a limiting factor in chronic pain. Delta opioid peptide (DOP)(δ) receptor antagonism has been shown to reduce tolerance. Here, the common…”
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C subunit of F1/FO-ATP synthase as target for preventing the detrimental effect of myocardial ischemia/reperfusion injury by Aquila, G., Morciano, G., De Marco, D., Preti, D., Pedriali, G., Trapella, C., Campo, G., Rizzo, P., Pinton, P.

“…Objective: The pathophysiological effects of coronary heart diseases are imputable to the hurtful consequences of ischemia-reperfusion injury (IRI).The opening…”
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Nocistatin inhibits 5‐hydroxytryptamine release in the mouse neocortex via presynaptic G i/o protein linked pathways by Fantin, M, Fischetti, C, Trapella, C, Morari, M

“…Background and purpose: Nocistatin (NST) is a neuropeptide generated from cleavage of the nociceptin/orphanin FQ (N/OFQ) precursor. Evidence has been presented…”
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In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1 by Camarda, V., Ruzza, C., Rizzi, A., Trapella, C., Guerrini, R., Reinscheid, R.K., Calo, G.

“…•The in vitro and in vivo pharmacological profile of novel NPSR ligands was assessed.•In vitro QA1 and PI1 behaved as pure and potent NPSR antagonists.•In…”
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Nocistatin inhibits 5‐hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways by Fantin, M, Fischetti, C, Trapella, C, Morari, M

“…Background and purpose: Nocistatin (NST) is a neuropeptide generated from cleavage of the nociceptin/orphanin FQ (N/OFQ) precursor. Evidence has been presented…”
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Synthesis and biological evaluation of new vinyl ester pseudotripeptide proteasome inhibitors by Marastoni, M., Baldisserotto, A., Trapella, C., Gavioli, R., Tomatis, R.

“…Here we report the synthesis and biological activities of new tripeptidic-based vinyl ester derivative proteasome inhibitors. Starting from Hmb-Val-Ser-Leu-VE…”
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Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist by Trapella, Claudio, Guerrini, Remo, Piccagli, Laura, Calo’, Girolamo, Carra’, Giacomo, Spagnolo, Barbara, Rubini, Samantha, Fanton, Giulia, Hebbes, Christopher, McDonald, John, Lambert, David G., Regoli, Domenico, Salvadori, Severo

“…The compound coded as Trap-101 is an achiral analogue of the nociceptin/orphanin FQ receptor antagonist J-113397 that combines a pharmacological profile…”
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HIV protease inhibitors: synthesis and activity of N-aryl- N′-hydroxyalkyl hydrazide pseudopeptides by Marastoni, M., Baldisserotto, A., Trapella, C., McDonald, J., Bortolotti, F., Tomatis, R.

“…We describe the synthesis and activities of a series of pseudopeptides containing an N-aryl- N′-hydroxyalkyl hydrazide core structure to inhibit human…”
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CONTRAST-ENHANCED HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY OF ARTICULAR CARTILAGE: IMAGING OUTCOME AND CORRELATION WITH TISSUE’S MECHANICS by Fantoni, S., Berni, M., Assenza, M., Cardarelli, P., Taibi, A., Trapella, C., Cristofori, V., Baruffaldi, F., Lopomo, N.F., Baleani, M.

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NOP receptor pharmacological profile - A dynamic mass redistribution study by Malfacini, Davide, Simon, Katharina, Trapella, Claudio, Guerrini, Remo, Zaveri, Nurulain T, Kostenis, Evi, Calo', Girolamo

“…The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (Gi/o) whose activation leads to the…”
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Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2 by Carra', G., Calo', G., Spagnolo, B., Guerrini, R., Arduin, M., Marzola, E., Trapella, C., Regoli, D., Salvadori, S.

“…:  In the present study we describe the in vitro pharmacological characterization of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) ligand Ac‐RYYRWK‐NH2 and…”
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Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity by Guerrini, R., Carra', G., Calo', G., Trapella, C., Marzola, E., Rizzi, D., Regoli, D., Salvadori, S.

“…:  Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the G‐protein coupled receptor referred to as N/OFQ peptide (NOP) receptor. NOP receptor…”
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The Nociceptin/Orphanin FQ Receptor Antagonist J-113397 and L-DOPA Additively Attenuate Experimental Parkinsonism through Overinhibition of the Nigrothalamic Pathway by Marti, Matteo, Trapella, Claudio, Viaro, Riccardo, Morari, Michele

“…By using a battery of behavioral tests, we showed that nociceptin/orphanin FQ receptor (NOP receptor) antagonists attenuated parkinsonian-like symptoms in…”
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A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ by Guerrini, Remo, Marzola, Erika, Trapella, Claudio, Pela’, Michela, Molinari, Stefano, Cerlesi, Maria Camilla, Malfacini, Davide, Rizzi, Anna, Salvadori, Severo, Calo’, Girolamo

“…Branched peptides have been found to be useful in several research fields however their synthesis and purification is complicated. Here we present a novel and…”
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