Search Results - "Trapani, Joseph A."

Perforin and granzymes: function, dysfunction and human pathology by Voskoboinik, Ilia, Whisstock, James C., Trapani, Joseph A.

“…Key Points This article reviews recent advances in the structural, cellular and clinical aspects of perforin and granzyme biology. It describes the cellular…”
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Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion by Voli, Florida, Valli, Emanuele, Lerra, Luigi, Kimpton, Kathleen, Saletta, Federica, Giorgi, Federico M, Mercatelli, Daniele, Rouaen, Jourdin R C, Shen, Sylvie, Murray, Jayne E, Ahmed-Cox, Aria, Cirillo, Giuseppe, Mayoh, Chelsea, Beavis, Paul A, Haber, Michelle, Trapani, Joseph A, Kavallaris, Maria, Vittorio, Orazio

“…Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in…”
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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity by Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O’Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

“…Natural killer (NK) cells have been reported to control adaptive immune responses that occur in lymphoid organs at the early stages of immune challenge…”
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Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time by Jenkins, Misty R, Rudd-Schmidt, Jesse A, Lopez, Jamie A, Ramsbottom, Kelly M, Mannering, Stuart I, Andrews, Daniel M, Voskoboinik, Ilia, Trapani, Joseph A

“…Failure of cytotoxic T lymphocytes (CTLs) or natural killer (NK) cells to kill target cells by perforin (Prf)/granzyme (Gzm)-induced apoptosis causes severe…”
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Lipid order and charge protect killer T cells from accidental death by Rudd-Schmidt, Jesse A., Hodel, Adrian W., Noori, Tahereh, Lopez, Jamie A., Cho, Hyun-Jung, Verschoor, Sandra, Ciccone, Annette, Trapani, Joseph A., Hoogenboom, Bart W., Voskoboinik, Ilia

“…Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTLs achieve this by forming an…”
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Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy by Nüssing, Simone, Trapani, Joseph A, Parish, Ian A

“…Immunotherapy has revolutionized the treatment of cancer. Nevertheless, the majority of patients do not respond to therapy, meaning a deeper understanding of…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Conformational changes during pore formation by the perforin-related protein pleurotolysin by Lukoyanova, Natalya, Kondos, Stephanie C, Farabella, Irene, Law, Ruby H P, Reboul, Cyril F, Caradoc-Davies, Tom T, Spicer, Bradley A, Kleifeld, Oded, Traore, Daouda A K, Ekkel, Susan M, Voskoboinik, Ilia, Trapani, Joseph A, Hatfaludi, Tamas, Oliver, Katherine, Hotze, Eileen M, Tweten, Rodney K, Whisstock, James C, Topf, Maya, Saibil, Helen R, Dunstone, Michelle A

“…Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and…”
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Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack by Lopez, Jamie A., Susanto, Olivia, Jenkins, Misty R., Lukoyanova, Natalya, Sutton, Vivien R., Law, Ruby H.P., Johnston, Angus, Bird, Catherina H., Bird, Phillip I., Whisstock, James C., Trapani, Joseph A., Saibil, Helen R., Voskoboinik, Ilia

“…Cytotoxic lymphocytes serve a key role in immune homeostasis by eliminating virus-infected and transformed target cells through the perforin-dependent delivery…”
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Real-time visualization of perforin nanopore assembly by Leung, Carl, Hodel, Adrian W., Brennan, Amelia J., Lukoyanova, Natalya, Tran, Sharon, House, Colin M., Kondos, Stephanie C., Whisstock, James C., Dunstone, Michelle A., Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R., Hoogenboom, Bart W.

“…Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can self-assemble into oligomeric…”
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Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function by Voskoboinik, Ilia, Trapani, Joseph A

“…Congenital perforin deficiency is considered a rare cause of human immunopathology and immune dysregulation, and classically presents as a fatal illness early…”
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Perforin: structure, function, and role in human immunopathology by Voskoboinik, Ilia, Dunstone, Michelle A, Baran, Katherine, Whisstock, James C, Trapani, Joseph A

“…The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes…”
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Functional significance of the perforin/granzyme cell death pathway by Trapani, Joseph A, Smyth, Mark J

“…Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to eliminate virus-infected or transformed cells. Studies in…”
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Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer by Dushyanthen, Sathana, Teo, Zhi Ling, Caramia, Franco, Savas, Peter, Mintoff, Christopher P., Virassamy, Balaji, Henderson, Melissa A., Luen, Stephen J., Mansour, Mariam, Kershaw, Michael H., Trapani, Joseph A., Neeson, Paul J., Salgado, Roberto, McArthur, Grant A., Balko, Justin M., Beavis, Paul A., Darcy, Phillip K., Loi, Sherene

“…The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is…”
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The structural basis for membrane binding and pore formation by lymphocyte perforin by Trapani, Joseph A, Saibil, Helen R, Whisstock, James C, Law, Ruby H. P, Lukoyanova, Natalya, Voskoboinik, Ilia, Caradoc-Davies, Tom T, Baran, Katherine, Dunstone, Michelle A, D'Angelo, Michael E, Orlova, Elena V, Coulibaly, Fasséli, Verschoor, Sandra, Browne, Kylie A, Ciccone, Annette, Kuiper, Michael J, Bird, Phillip I

“…Natural killer cells and cytotoxic T lymphocytes accomplish the critically important function of killing virus-infected and neoplastic cells. They do this by…”
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PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia by Li, Jessica, Whelan, Sarah, Kotturi, Maya F, Meyran, Deborah, D'Souza, Criselle, Hansen, Kyle, Liang, Spencer, Hunter, John, Trapani, Joseph A, Neeson, Paul J

“…This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). We showed…”
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Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma by Flinsenberg, Thijs W H, Tromedjo, Charnelle C, Hu, Nan, Liu, Ye, Guo, Yin, Thia, Kevin Y T, Noori, Tahereh, Song, Xiaomin, Aw Yeang, Han X, Tantalo, Daniela G, Handunnetti, Sasanka, Seymour, John F, Roberts, Andrew W, Ritchie, David, Koldej, Rachel, Neeson, Paul J, Wang, Lai, Trapani, Joseph A, Tam, Constantine S, Voskoboinik, Ilia

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Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H by Feehan, David D, Jamil, Khusraw, Polyak, Maria J, Ogbomo, Henry, Hasell, Mark, Li, Shu Shun, Xiang, Richard F, Parkins, Michael, Trapani, Joseph A, Harrison, Joe J, Mody, Christopher H

“…Pseudomonas aeruginosa is an opportunistic pathogen that often infects individuals with the genetic disease cystic fibrosis, and contributes to airway blockage…”
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The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy by Hsu, Andy K., Quach, Hang, Tai, Tsin, Prince, H. Miles, Harrison, Simon J., Trapani, Joseph A., Smyth, Mark J., Neeson, Paul, Ritchie, David S.

“…Lenalidomide combined with dexamethasone is an effective treatment for refractory/relapsed multiple myeloma (MM). Lenalidomide stimulates natural killer (NK)…”
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Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance by Wagle, Mayura V., Vervoort, Stephin J., Kelly, Madison J., Van Der Byl, Willem, Peters, Timothy J., Martin, Ben P., Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James R., Knight, Deborah, Reading, Sinead, Thia, Kevin, Miosge, Lisa A., Howard, Debbie R., Gloury, Renee, Gabriel, Sarah S., Utzschneider, Daniel T., Oliaro, Jane, Powell, Jonathan D., Luciani, Fabio, Trapani, Joseph A., Johnstone, Ricky W., Kallies, Axel, Goodnow, Christopher C., Parish, Ian A.

“…Chronic stimulation of CD8 + T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple…”
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