Search Results - "Trapani, Angelo J"

Alternative Complement Pathway Inhibition With Iptacopan for the Treatment of C3 Glomerulopathy-Study Design of the APPEAR-C3G Trial by Bomback, Andrew S., Kavanagh, David, Vivarelli, Marina, Meier, Matthias, Wang, Yaqin, Webb, Nicholas J.A., Trapani, Angelo J., Smith, Richard J.H.

“…Complement 3 glomerulopathy (C3G) is a rare kidney disease characterized by dysregulation of the alternative pathway (AP) of the complement system. About 50%…”
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Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme by Wallace, Eli M, Moliterni, John A, Moskal, Michael A, Neubert, Alan D, Marcopulos, Nicholas, Stamford, Lisa B, Trapani, Angelo J, Savage, Paula, Chou, Mary, Jeng, Arco Y

“…Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion…”
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BLOCKADE OF ALDOSTERONE PRODUCTION AS A NOVEL APPROACH TO THE MANAGEMENT OF HIGH BLOOD PRESSURE: EFFICACY AND TOLERABILITY OF THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN PATIENTS WITH STAGE 1-2 HYPERTENSION by White, William B, Calhoun, David A, Krum, Henry, Guo, Weinong, Trapani, Angelo J, Lefkowitz, Martin, Menard, Joel

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Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action by De Lombaert, Stéphane, Blanchard, Louis, Stamford, Lisa B, Tan, Jenny, Wallace, Eli M, Satoh, Yoshitaka, Fitt, John, Hoyer, Denton, Simonsbergen, David, Moliterni, John, Marcopoulos, Nicholas, Savage, Paula, Chou, Mary, Trapani, Angelo J, Jeng, Arco Y

“…Potent and selective non-peptidic inhibitors of human endothelin-converting enzyme-1 (ECE-1) have been designed as potential modulators of endothelin (ET-1)…”
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CGS 35601 and its Orally Active Prodrug CGS 37808 as Triple Inhibitors of Endothelin-converting Enzyme-1, Neutral Endopeptidase 24.11, and Angiotensin-converting Enzyme by Trapani, Angelo J, Beil, Michael E, Bruseo, Charles W, Savage, Paula, Firooznia, Fariborz, Jeng, Arco Y

“…CGS 35601 is a potent triple inhibitor of endothelinconverting enzyme-1, neutral endopeptidase 24.11, and angiotensinconverting enzyme. It inhibited the…”
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CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11 by Jeng, Arco Y, Savage, Paula, Beil, Michael E, Bruseo, Charles W, Hoyer, Denton, Fink, Cynthia A, Trapani, Angelo J

“…Endothelins (ETs) are potent vasoconstrictors and have been implicated in the pathogenesis of various cardiovascular and renal diseases. In contrast, atrial…”
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12M Interim Analysis of an Open-Label, Non-Randomized Extension of a Phase 2 Study to Evaluate the Long-Term Efficacy, Safety, and Tolerability of Iptacopan in Subjects With C3G: TH-PO505 by Nester, Carla M., Eisenberger, Ute, Karras, Alexandre, Lightstone, Liz, Praga, Manuel, Remuzzi, Giuseppe, Soler, Maria Jose, Liu, Junhao, Meier, Matthias, Tawfik, Ronda, Junge, Guido, Biondani, Andrea, Trapani, Angelo J., Webb, Nicholas, Wong, Edwin K.

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Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1 by Firooznia, Fariborz, Gude, Candido, Chan, Kenneth, Tan, Jenny, Fink, Cynthia A., Savage, Paula, Beil, Michael E., Bruseo, Charles W., Trapani, Angelo J., Jeng, Arco Y.

“…Directed screening of metalloprotease inhibitors identified CGS 30084 ( 1) as a potent inhibitor of endothelin-converting enzyme-1 (ECE-1) in vitro (IC 50=77…”
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Effects of the ECE/NEP inhibitor CGS 34225 on the big ET-1-induced pressor response and plasma atrial natriuretic peptide concentration in conscious rats by Trapani, Angelo J, Beil, Michael E, Bruseo, Charles W, Fink, Cynthia A, Hoyer, Denton, Savage, Paula, Jeng, Arco Y

“…CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11…”
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LNP023: A Novel Oral Complement Alternative Pathway Factor B Inhibitor Safely and Effectively Reduces Proteinuria in C3 Glomerulopathy: SU-OR39 by Wong, Edwin K., Praga, Manuel, Nester, Carla M., Daina, Erica, Remuzzi, Giuseppe, Nidamarthy, Prasanna Kumar, End, Peter R., Milojevic, Julie M., Biondani, Andrea, Trapani, Angelo J., Webb, Nicholas, Junge, Dr Guido

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N-Phosphonomethyl Dipeptides and Their Phosphonate Prodrugs, a New Generation of Neutral Endopeptidase (NEP, EC 3.4.24.11) Inhibitors by De Lombaert, Stephane, Erion, Mark D, Tan, Jenny, Blanchard, Louis, El-Chehabi, Lena, Ghai, R. D, Sakane, Yumi, Berry, Carol, Trapani, Angelo J

“…Inhibitors of the zinc protease neutral endopeptidase (NEP, EC 3.4.24.11) offer significant therapeutic interest as antihypertensives due to their ability to…”
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Design and Synthesis of a Potent and Selective Endothelin-Converting Enzyme Inhibitor, CGS 35066 by Jeng, Arco Y, De Lombaert, Stéphane, Beil, Michael E, Bruseo, Charles W, Savage, Paula, Chou, Mary, Trapani, Angelo J

“…CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal…”
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Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1 by Fink, Cynthia A, Moskal, Michael, Firooznia, Fariborz, Hoyer, Denton, Symonsbergen, David, Wei, Dongchu, Qiao, Ying, Savage, Paula, Beil, Michael E, Trapani, Angelo J, Jeng, Arco Y

“…Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084, that had potent endothelin converting enzyme-1 (ECE-1) in…”
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Pharmacological Properties of CGS 35066, a Potent and Selective Endothelin-Converting Enzyme Inhibitor, in Conscious Rats by Trapani, Angelo J, Beil, Michael E, Bruseo, Charles W, De Lombaert, Stéphane, Jeng, Arco Y

“…The purpose of this study was to examine the pharmacologic properties of CGS 35066, a novel aminophosphonate inhibitor of endothelin-converting enzyme-1…”
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Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors by FIROOZNIA, Fariborz, GUDE, Candido, TRAPANI, Angelo J, JENG, Arco Y, CHAN, Kenneth, FINK, Cynthia A, YING QIAO, SATOH, Yoshitaka, MARCOPOULOS, Nicholas, SAVAGE, Paula, BEIL, Michael E, BRUSEO, Charles W

“…Through directed screening of metalloprotease inhibitors, CGS 30084 (1) has been identified as a potent endothelin-converting enzyme-1 (ECE-1) inhibitor in…”
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Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy by Nester, Carla M., Eisenberger, Ute, Karras, Alexandre, le Quintrec, Moglie, Lightstone, Liz, Praga, Manuel, Remuzzi, Giuseppe, Soler, Maria José, Liu, Junhao, Meier, Matthias, Tawfik, Ronda, Junge, Guido, Biondani, Andrea, Trapani, Angelo J., Webb, Nicholas J.A., Wong, Edwin K.S.

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Mercaptoacyl Dipeptides as Orally Active Dual Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase by Fink, Cynthia A, Carlson, J. Eric, McTaggart, Patricia A, Qiao, Ying, Webb, Randy, Chatelain, Ricardo, Jeng, Arco Y, Trapani, Angelo J

“…Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24.11) and angiotensin-I-converting enzyme (ACE, EC 2.4.15.1), have been…”
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Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11 by Chatelain, R E, Ghai, R D, Trapani, A J, Odorico, L M, Dardik, B N, De Lombaert, S, Lappe, R W, Fink, C A

“…Dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitors, by decreasing angiotensin-II production and by preventing the degradation of…”
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New .alpha.-Thiol Dipeptide Dual Inhibitors of Angiotensin-I-Converting Enzyme and Neutral Endopeptidase EC 3.4.24.11 by Fink, Cynthia A, Qiao, Ying, Berry, Carol J, Sakane, Yumi, Ghai, Rajendra D, Trapani, Angelo J

“…Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24.11) and angiotensin-I converting enzyme, have been the focus of much…”
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Benzofused Macrocyclic Lactams as Triple Inhibitors of Endothelin-Converting Enzyme, Neutral Endopeptidase 24.11, and Angiotensin-Converting Enzyme by Ksander, Gary M, Savage, Paula, Trapani, Angelo J, Balwierczak, Joseph L, Jeng, Arco Y

“…The purpose of this study was to identify endothelin-converting enzyme (ECE) inhibitors that also possess inhibitory activity for neutral endopeptidase 24.11…”
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