Search Results - "Translational research : the journal of laboratory and clinical medicine"

Targeting inflammation in metabolic syndrome by Welty, Francine K, Alfaddagh, Abdulhamied, Elajami, Tarec K

“…The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors, including visceral adiposity, insulin resistance, hypertension, high…”
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Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques by Jiang, Kai, Ferguson, Christopher M., Lerman, Lilach O.

“…Renal fibrosis is a useful biomarker for diagnosis and guidance of therapeutic interventions of chronic kidney disease (CKD), a worldwide disease that affects…”
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Diabetes mellitus, a microRNA-related disease? by Guay, Claudiane, Roggli, Elodie, Nesca, Valeria, Jacovetti, Cécile, Regazzi, Romano

“…Diabetes mellitus is a complex disease resulting in altered glucose homeostasis. In both type 1 and type 2 diabetes mellitus, pancreatic β cells cannot secrete…”
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Serum biomarkers for diagnosis and prediction of type 1 diabetes by Yi, Lian, Swensen, Adam C., Qian, Wei-Jun

“…Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells, leading to insufficient production of insulin and development of…”
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Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study by Zee, Robert Y.L, Castonguay, Amy J, Barton, Nathaniel S, Germer, Soren, Martin, Mitchell

“…Recent data have implicated leukocyte telomere length shortening as a potential risk predictor for type 2 diabetes mellitus (T2DM) and its associated…”
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Triple-tyrosine kinase inhibition attenuates pulmonary arterial hypertension and neointimal formation by Ambade, Anjira S., Jung, Birgit, Lee, Dongwon, Doods, Henri, Wu, Dongmei

“…The present study examined the effects of simultaneous inhibition of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and…”
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Using GWAS to identify novel therapeutic targets for osteoporosis by Sabik, Olivia L, Farber, Charles R

“…Osteoporosis is a common, increasingly prevalent, global health burden characterized by low bone mineral density (BMD) and increased risk of fracture. Despite…”
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Biomarkers for systemic lupus erythematosus by Ahearn, Joseph M, Liu, Chau-Ching, Kao, Amy H, Manzi, Susan

“…The urgent need for lupus biomarkers was demonstrated in September 2011 during a Workshop sponsored by the Food and Drug Administration: Potential Biomarkers…”
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Stem cells for skeletal muscle regeneration: therapeutic potential and roadblocks by Rinaldi, Fabrizio, Perlingeiro, Rita C.R

“…Conditions involving muscle wasting, such as muscular dystrophies, cachexia, and sarcopenia, would benefit from approaches that promote skeletal muscle…”
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Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis by Kinoshita, Yukiko, Kondo, Shuji, Urushihara, Maki, Suga, Kenichi, Matsuura, Sato, Takamatsu, Masanori, Shimizu, Maki, Nishiyama, Akira, Kawachi, Hiroshi, Kagami, Shoji

“…Excessive renin-angiotensin system (RAS) activation within the kidney induces not only renal oxidative stress but also renal scarring and dysfunction. This…”
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Heart, kidney, and intestine have different tolerances for anemia by van Bommel, Jasper, Siegemund, Martin, Henny, Ch. Pieter, Ince, Can

“…Organ systems do not respond uniformly to changes in systemic oxygen delivery because of global and local redistributive mechanisms. We hypothesized that…”
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Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty rats by Leehey, David J, Singh, Ashok K, Bast, Joseph P, Sethupathi, Periannan, Singh, Rekha

“…Substantial evidence suggests that the intrarenal renin-angiotensin system (RAS) plays a role in the pathogenesis of diabetic nephropathy. Although the…”
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Noninvasive assessment of insulin resistance in the liver using the fasting 13C-glucose breath test by Tanaka, Ken, Matsuura, Tomokazu, Shindo, Daisuke, Aida, Yuta, Matsumoto, Yoshihiro, Nagatsuma, Keisuke, Saito, Masaya, Ishii, Hirotaka, Abe, Hiroshi, Tanaka, Fumihiko, Shimada, Takao, Nakada, Koji, Ikewaki, Katsunori, Aizawa, Yoshio, Tajiri, Hisao, Suzuki, Masato

“…Evaluating hepatic insulin resistance (IR) is the key to making a sensitive an accurate diagnosis of glucose intolerance. However, there is currently no…”
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Immunopathogenesis of hypersensitivity syndrome reactions to sulfonamides by Neuman, Manuela G, Shear, Neil H, Malkiewicz, Izabella M, Taeri, Masud, Shapiro, Lori E, Krivoy, Norberto, Haber, Julia, Gomez, Manuel, Fish, Joel, Cartotto, Robert, Cohen, Lawrence

“…Cytokines play a role in the immunopathological and molecular mechanisms of sulfonamide-induced hypersensitivity reactions (HSRs). The objective of this study…”
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Skin ulcers in Klippel–Trenaunay syndrome respond to sunitinib by Nguyen, Sheila, Franklin, Michael, Dudek, Arkadiusz Z

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Macrophage polarization and diabetic wound healing by Louiselle, Amanda E., Niemiec, Stephen M., Zgheib, Carlos, Liechty, Kenneth W.

“…Diabetes mellitus is a costly disease and nearly one-third of these costs are attributed to management of diabetic foot disease including chronic, non-healing,…”
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Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases by Magro, Cynthia, Mulvey, J. Justin, Berlin, David, Nuovo, Gerard, Salvatore, Steven, Harp, Joanna, Baxter-Stoltzfus, Amelia, Laurence, Jeffrey

“…Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity and mortality characterizing infection with severe acute…”
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miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer by Zhong, Shen, Golpon, Heiko, Zardo, Patrick, Borlak, Jürgen

“…Lung cancer (LC) is the leading cause of cancer-related death worldwide and miRNAs play a key role in LC development. To better diagnose LC and to predict drug…”
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Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients by de GONZALO-CALVO, DAVID, BENÍTEZ, IVÁN D., PINILLA, LUCÍA, CARRATALÁ, AMARA, MONCUSÍ-MOIX, ANNA, GORT-PANIELLO, CLARA, MOLINERO, MARTA, GONZÁLEZ, JESSICA, TORRES, GERARD, BERNAL, MARÍA, PICO, SILVIA, ALMANSA, RAQUEL, JORGE, NOELIA, ORTEGA, ALICIA, BUSTAMANTE-MUNGUIRA, ELENA, GÓMEZ, JOSÉ MANUEL, GONZÁLEZ-RIVERA, MILAGROS, MICHELOUD, DARIELA, RYAN, PABLO, MARTINEZ, AMALIA, TAMAYO, LUIS, ALDECOA, CÉSAR, FERRER, RICARD, CECCATO, ADRIÁN, FERNÁNDEZ-BARAT, LAIA, MOTOS, ANA, RIERA, JORDI, MENÉNDEZ, ROSARIO, GARCIA-GASULLA, DARIO, PEÑUELAS, OSCAR, TORRES, ANTONI, BERMEJO-MARTIN, JESÚS F., BARBÉ, FERRAN

“…We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19 patients and evaluate its potential as a source of biomarkers for the…”
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Smoking and the Risk of Type 2 Diabetes by Maddatu, Judith, Anderson-Baucum, Emily, Evans-Molina, Carmella

“…Abstract Despite accumulating evidence demonstrating strong epidemiological and mechanistic associations between cigarette smoking, hyperglycemia, and the…”
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