Search Results - "Translational neurodegeneration"

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes by Kwon, Hyuk Sung, Koh, Seong-Ho

“…Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia…”
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Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential by Gao, Lina, Zhang, Yun, Sterling, Keenan, Song, Weihong

“…Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to arise as the disease progresses. A growing body of evidence…”
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Current understanding of metal ions in the pathogenesis of Alzheimer's disease by Wang, Lu, Yin, Ya-Ling, Liu, Xin-Zi, Shen, Peng, Zheng, Yan-Ge, Lan, Xin-Rui, Lu, Cheng-Biao, Wang, Jian-Zhi

“…The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have…”
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Alzheimer's disease hypothesis and related therapies by Du, Xiaoguang, Wang, Xinyi, Geng, Meiyu

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including…”
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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration by Verma, Manish, Lizama, Britney N, Chu, Charleen T

“…Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high…”
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The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease by Pang, Shirley Yin-Yu, Ho, Philip Wing-Lok, Liu, Hui-Fang, Leung, Chi-Ting, Li, Lingfei, Chang, Eunice Eun Seo, Ramsden, David Boyer, Ho, Shu-Leong

“…Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies…”
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Protein misfolding in neurodegenerative diseases: implications and strategies by Sweeney, Patrick, Park, Hyunsun, Baumann, Marc, Dunlop, John, Frydman, Judith, Kopito, Ron, McCampbell, Alexander, Leblanc, Gabrielle, Venkateswaran, Anjli, Nurmi, Antti, Hodgson, Robert

“…A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular…”
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Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments by Maiti, Panchanan, Manna, Jayeeta, Dunbar, Gary L

“…Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are…”
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Neuroinflammation in Parkinson's disease and its potential as therapeutic target by Wang, Qinqin, Liu, Yingjun, Zhou, Jiawei

“…Parkinson's disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the…”
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Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein by Zou, Wenyan, Pu, Tinglin, Feng, Weixi, Lu, Ming, Zheng, Ying, Du, Renhong, Xiao, Ming, Hu, Gang

“…Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson's disease (PD), thus, it is reliable to promote the clearance of…”
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Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond by Song, Chenghuan, Shi, Jiyun, Zhang, Pingao, Zhang, Yongfang, Xu, Jianrong, Zhao, Lanxue, Zhang, Rui, Wang, Hao, Chen, Hongzhuan

“…Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly worldwide. However, the complexity of AD pathogenesis leads to…”
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Advances in the development of new biomarkers for Alzheimer's disease by Klyucherev, Timofey O, Olszewski, Pawel, Shalimova, Alena A, Chubarev, Vladimir N, Tarasov, Vadim V, Attwood, Misty M, Syvänen, Stina, Schiöth, Helgi B

“…Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most common type of neurodegenerative dementia. The prevalence of AD is…”
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The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration by Hu, Yong-Bo, Dammer, Eric B, Ren, Ru-Jing, Wang, Gang

“…The endosomal-lysosomal system is made up of a set of intracellular membranous compartments that dynamically interconvert, which is comprised of early…”
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Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments by Gao, Chao, Liu, Jun, Tan, Yuyan, Chen, Shengdi

“…Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD), but the mechanisms and treatments of FOG remain great challenges for…”
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Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives by Cheng, Yuan, Tian, Ding-Yuan, Wang, Yan-Jiang

“…Alzheimer's disease (AD) is the most common type of dementia, and no disease-modifying treatments are available to halt or slow its progression. Amyloid-beta…”
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Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy by De Luca, Chiara Maria Giulia, Elia, Antonio Emanuele, Portaleone, Sara Maria, Cazzaniga, Federico Angelo, Rossi, Martina, Bistaffa, Edoardo, De Cecco, Elena, Narkiewicz, Joanna, Salzano, Giulia, Carletta, Olga, Romito, Luigi, Devigili, Grazia, Soliveri, Paola, Tiraboschi, Pietro, Legname, Giuseppe, Tagliavini, Fabrizio, Eleopra, Roberto, Giaccone, Giorgio, Moda, Fabio

“…Parkinson's disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative…”
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The role of pathological tau in synaptic dysfunction in Alzheimer's diseases by Wu, Moxin, Zhang, Manqing, Yin, Xiaoping, Chen, Kai, Hu, Zhijian, Zhou, Qin, Cao, Xianming, Chen, Zhiying, Liu, Dan

“…Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and…”
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Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer's disease and dementia with Lewy bodies by Gámez-Valero, Ana, Campdelacreu, Jaume, Vilas, Dolores, Ispierto, Lourdes, Reñé, Ramón, Álvarez, Ramiro, Armengol, M Pilar, Borràs, Francesc E, Beyer, Katrin

“…Because of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these…”
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The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms by Schultz, Bob G, Patten, Denise K, Berlau, Daniel J

“…Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their…”
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Parkinson's disease in China: a forty-year growing track of bedside work by Li, Gen, Ma, Jianfang, Cui, Shishuang, He, Yixi, Xiao, Qin, Liu, Jun, Chen, Shengdi

“…The number and health burden of Parkinson's disease increase rapidly in China. It is estimated that China will have nearly half of the Parkinson's disease…”
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