Search Results - "Translational Physiology"

Nrf2 at the heart of oxidative stress and cardiac protection by Chen, Qin M, Maltagliati, Anthony J

“…The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the expression of antioxidant and detoxification genes. Gene knockout…”
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Chronic kidney disease and the gut microbiome by Hobby, Gerren P, Karaduta, Oleg, Dusio, Giuseppina F, Singh, Manisha, Zybailov, Boris L, Arthur, John M

“…The gut microbiome is composed of a diverse population of bacteria that have beneficial and adverse effects on human health. The microbiome has recently gained…”
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Bilirubin as a metabolic hormone: the physiological relevance of low levels by Creeden, Justin F, Gordon, Darren M, Stec, David E, Hinds, Jr, Terry D

“…Recent research on bilirubin, a historically well-known waste product of heme catabolism, suggests an entirely new function as a metabolic hormone that drives…”
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Medial prefrontal cortex in neurological diseases by Xu, Pan, Chen, Ai, Li, Yipeng, Xing, Xuezhi, Lu, Hui

“…The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated…”
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Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice by Crotty Alexander, Laura E, Drummond, Christopher A, Hepokoski, Mark, Mathew, Denzil, Moshensky, Alex, Willeford, Andrew, Das, Soumita, Singh, Prabhleen, Yong, Zach, Lee, Jasmine H, Vega, Kevin, Du, Ashley, Shin, John, Javier, Christian, Tian, Jiang, Brown, Joan Heller, Breen, Ellen C

“…Electronic (e)-cigarettes theoretically may be safer than conventional tobacco. However, our prior studies demonstrated direct adverse effects of e-cigarette…”
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Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition by Tang, Haiyang, Babicheva, Aleksandra, McDermott, Kimberly M, Gu, Yali, Ayon, Ramon J, Song, Shanshan, Wang, Ziyi, Gupta, Akash, Zhou, Tong, Sun, Xutong, Dash, Swetaleena, Wang, Zilu, Balistrieri, Angela, Zheng, Qiuyu, Cordery, Arlette G, Desai, Ankit A, Rischard, Franz, Khalpey, Zain, Wang, Jian, Black, Stephen M, Garcia, Joe G N, Makino, Ayako, Yuan, Jason X-J

“…Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal obliteration is a major contributor to the elevated pulmonary…”
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LungMAP: The Molecular Atlas of Lung Development Program by Ardini-Poleske, Maryanne E, Clark, Robert F, Ansong, Charles, Carson, James P, Corley, Richard A, Deutsch, Gail H, Hagood, James S, Kaminski, Naftali, Mariani, Thomas J, Potter, Steven S, Pryhuber, Gloria S, Warburton, David, Whitsett, Jeffrey A, Palmer, Scott M, Ambalavanan, Namasivayam

“…The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource…”
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Thoughts on the alveolar phase of COVID-19 by Mason, Robert J

“…COVID-19 can be divided into three clinical stages, and one can speculate that these stages correlate with where the infection resides. For the asymptomatic…”
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Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats by Thomson, Scott Culver, Vallon, Volker

“…Inhibitors of the main proximal tubular Na-glucose cotransporter (SGLT2) mitigate diabetic glomerular hyperfiltration and have been approved by the United…”
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"I don't get no respect": the role of chloride in acute kidney injury by Rein, Joshua L, Coca, Steven G

“…Acute kidney injury (AKI) is a major public health problem that complicates 10-40% of hospital admissions. Importantly, AKI is independently associated with…”
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Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both by Marshall, Jeffrey D, Bazan, Isabel, Zhang, Yi, Fares, Wassim H, Lee, Patty J

“…Pulmonary hypertension describes a heterogeneous disease defined by increased pulmonary artery pressures, and progressive increase in pulmonary vascular…”
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SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19 by van Kempen, Theo A T G, Deixler, Elisabeth

“…The use of vitamin D to reduce the severity of COVID-19 complications is receiving considerable attention, backed by encouraging data. Its purported mode of…”
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Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study by Rajasekeran, Harindra, Reich, Heather N, Hladunewich, Michelle A, Cattran, Daniel, Lovshin, Julie A, Lytvyn, Yuliya, Bjornstad, Petter, Lai, Vesta, Tse, Josephine, Cham, Leslie, Majumder, Syamantak, Bowskill, Bridgit B, Kabir, M Golam, Advani, Suzanne L, Gibson, Ian W, Sood, Manish M, Advani, Andrew, Cherney, David Z I

“…Focal segmental glomerulosclerosis (FSGS) is an important cause of nondiabetic chronic kidney disease (CKD). Sodium-glucose cotransporter 2 inhibition (SGLT2i)…”
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Artificial intelligence, physiological genomics, and precision medicine by Williams, Anna Marie, Liu, Yong, Regner, Kevin R, Jotterand, Fabrice, Liu, Pengyuan, Liang, Mingyu

“…Big data are a major driver in the development of precision medicine. Efficient analysis methods are needed to transform big data into clinically-actionable…”
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Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury by Zhang, Wei, Guan, Yinjie, Bayliss, George, Zhuang, Shougang

“…Sepsis-associated acute kidney injury (SA-AKI) is associated with high mortality rates, but clinicians lack effective treatments except supportive care or…”
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Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease by Redente, Elizabeth F, Aguilar, Martin A, Black, Bart P, Edelman, Benjamin L, Bahadur, Ali N, Humphries, Stephen M, Lynch, David A, Wollin, Lutz, Riches, David W H

“…Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in ~20% of patients with RA. SKG mice, which are genetically prone to…”
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Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats by McGarrah, Robert W, Zhang, Guo-Fang, Christopher, Bridgette A, Deleye, Yann, Walejko, Jacquelyn M, Page, Stephani, Ilkayeva, Olga, White, Phillip J, Newgard, Christopher B

“…Elevations in circulating levels of branched-chain amino acids (BCAAs) are associated with a variety of cardiometabolic diseases and conditions. Restriction of…”
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Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation by Chen, Jiyuan, Rodriguez, Marisela, Miao, Jinrui, Liao, Jing, Jain, Pritesh P, Zhao, Manjia, Zhao, Tengteng, Babicheva, Aleksandra, Wang, Ziyi, Parmisano, Sophia, Powers, Ryan, Matti, Moreen, Paquin, Cole, Soroureddin, Zahra, Shyy, John Y-J, Thistlethwaite, Patricia A, Makino, Ayako, Wang, Jian, Yuan, Jason X-J

“…Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery (PA) smooth muscle cell (PASMC) proliferation contributes to…”
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Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise by Ramos, Anna E, Lo, Claire, Estephan, Leonard E, Tai, Yi-Yin, Tang, Ying, Zhao, Jingsi, Sugahara, Masataka, Gorcsan, 3rd, John, Brown, Marcel G, Lieberman, Daniel E, Chan, Stephen Y, Baggish, Aaron L

“…Circulating microRNAs (c-miRNAs), plasma-based noncoding RNAs that control posttranscriptional gene expression, mediate processes that underlie phenotypical…”
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Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial by Kirkman, Danielle L, Ramick, Meghan G, Muth, Bryce J, Stock, Joseph M, Pohlig, Ryan T, Townsend, Raymond R, Edwards, David G

“…Endothelial dysfunction and arterial stiffness are nontraditional risk factors of chronic kidney disease (CKD)-related cardiovascular disease (CVD) that could…”
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