Search Results - "Tranquill, L"

Mechanisms of immunomodulation by glatiramer acetate by GRAN, B, TRANQUILL, L. R, CHEN, M, BIELEKOVA, B, ZHOU, W, DHIB-JALBUT, S, MARTIN, R

“…To define the mechanism of action of glatiramer acetate (GA; formerly known as copolymer-1) as an immunomodulatory treatment for MS. The proposed mechanisms of…”
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Phase 1 trial of transforming growth factor beta 2 in chronic progressive MS by CALABRESI, P. A, FIELDS, N. S, MCFARLAND, H. F, RACKE, M. K, MALONI, H. W, HANHAM, A, CARLINO, J, MOORE, J, LEVIN, M. C, DHIB-JALBUT, S, TRANQUILL, L. R, AUSTIN, H

“…Transforming growth factor (TGF)-beta2 is a pleiotropic cytokine associated with remissions in multiple sclerosis (MS) and amelioration of allergic…”
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VLA-4 expression on peripheral blood lymphocytes is downregulated after treatment of multiple sclerosis with interferon beta by CALABRESI, P. A, PELFREY, C. M, TRANQUILL, L. R, MALONI, H, MCFARLAND, H. F

“…Adhesion molecules are likely to play a critical role in the immunopathogenesis of multiple sclerosis (MS). The interaction of vascular cell adhesion…”
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Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients by Tranquill, Laura R, Cao, Ligong, Ling, Nicholas C, Kalbacher, Hubert, Martin, Roland M, Whitaker, John N

“…Myelin basic protein (MBP), a candidate autoantigen in multiple sclerosis (MS), exists in different isoforms and charge isomers generated by differential…”
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Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients by Tranquill, L.R., Cao, L., Ling, N.C., Kalbacher, H., Martin, R.M., Whitaker, J.N.

“…Myelin basic protein (MBP), a candidate autoantigen in multiple sclerosis (MS), exists in different isoforms and charge isomers generated by differential…”
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Cytokine gene expression in cells derived from CSF of multiple sclerosis patients by Calabresi, P.A, Tranquill, L.R, McFarland, H.F, Cowan, E.P

“…Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of…”
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Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon beta-1b by Calabresi, P A, Tranquill, L R, Dambrosia, J M, Stone, L A, Maloni, H, Bash, C N, Frank, J A, McFarland, H F

“…Interferon beta-1b reduces clinical exacerbations and disease activity in multiple sclerosis as shown by magnetic resonance imaging, but the mechanism of…”
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Human T-cell response to myelin basic protein peptide (83-99): Extensive heterogeneity in antigen recognition, function, and phenotype by HEMMER, B, VERGELLI, M, TRANQUILL, L, CONLON, P, LING, N, MCFARLAND, H. F, MARTIN, R

“…Multiple sclerosis (MS) is considered a T cell-mediated autoimmune disease, and myelin proteins are the most likely candidate autoantigens. Based on…”
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Identification of a novel T cell epitope of human proteolipid protein (residues 40-60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients by Pelfrey, C M, Trotter, J L, Tranquill, L R, McFarland, H F

“…Research into the pathogenesis of multiple sclerosis (MS) has focused on myelin antigens as potential targets of autoimmune attack. Proteolipid protein (PLP),…”
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T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells by Vergelli, M, Kalbus, M, Rojo, S.C, Hemmer, B, Kalbacher, H, Tranquill, L, Beck, H, McFarland, H.F, De Mars, R, Long, E.O, Martin, R

“…In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR α paired with the β chain encoded by DRB5 *0101) and DR2b (DR α paired…”
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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B10401) subjects is associated with a restricted T cell receptor repertoire by Muraro, P A, Vergelli, M, Kalbus, M, Banks, D E, Nagle, J W, Tranquill, L R, Nepom, G T, Biddison, W E, McFarland, H F, Martin, R

“…The pathogenesis of multiple sclerosis (MS) is currently ascribed in part to a T cell-mediated process targeting myelin components. The T cell response to one…”
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T cell response to two immunodominant proteolipid protein (PLP) peptides in multiple sclerosis patients and healthy controls by Pelfrey, C M, Tranquill, L R, Vogt, A B, McFarland, H F

“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which autoimmune T lymphocytes reacting with myelin antigens are believed…”
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Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic protein: Recognition of golli MBP HOG 7 by Tranquill, L.R., Skinner, E., Campagnoni, C., Vengelli, M., Hemmer, B., Muraro, P., Martin, R., McFarland, H.F., Campagnoni, A.T., Voskuhl, R.R.

“…Myelin basic protein (MBP) is a candidate auto‐antigen in the disease multiple sclerosis. Although MBP was thought to be sequestered behind the blood‐brain…”
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A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination by Voskuhl, R R, McFarlin, D E, Tranquill, L R, Deibler, G, Stone, R, Maloni, H, McFarland, H F

“…Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein…”
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Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals by Pelfrey, CM, Tranquill, LR, Boehme, SA, McFarland, HF, Lenardo, MJ

“…Several stimuli induce mature T cells to undergo apoptosis or programmed cell death (PCD) including specific Ag. We have demonstrated previously that Ag…”
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Identification of a second T cell epitope of human proteolipid protein (residues 89-106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients by Pelfrey, C M, Trotter, J L, Tranquill, L R, McFarland, H F

“…Research into the pathogenesis of multiple sclerosis (MS) has focused on myelin antigens as potential targets of autoimmune attack. Proteolipid protein (PLP)…”
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Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand- mediated pathways for target cell lysis by Vergelli, M, Hemmer, B, Muraro, PA, Tranquill, L, Biddison, WE, Sarin, A, McFarland, HF, Martin, R

“…It is well established that target cell lysis by MHC class I-restricted CD8+ T cells is an important defense mechanism during infections with intracellular…”
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Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99) by Vergelli, M, Hemmer, B, Utz, U, Vogt, A, Kalbus, M, Tranquill, L, Conlon, P, Ling, N, Steinman, L, McFarland, H F, Martin, R

“…We have examined the functional consequences induced by interaction of DR2a-restricted myelin basic protein (MBP) (87-99)-specific T cell clones (TCC) with…”
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Human autoreactive CD4 super(+) T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis by Vergelli, M, Hemmer, B, Muraro, P A, Tranquill, L, Biddison, W E, Sarin, A, McFarland, H F, Martin, R

“…It is well established that target cell lysis by MHC class I-restricted CD8 super(+) T cells is an important defense mechanism during infections with…”
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HLA restriction and TCR usage of T lymphocytes specific for a novel candidate autoantigen, X2 MBP, in multiple sclerosis by Voskuhl, RR, Robinson, ED, Segal, BM, Tranquill, L, Camphausen, K, Albert, PS, Richert, JR, McFarland, HF

“…Previous investigations of the major 18.5-kDa isoform of myelin basic protein (MBP) as a target autoantigen in multiple sclerosis (MS) have failed to identify…”
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