Search Results - "Tranier, Samuel"

Structural Investigation of the Thermostability and Product Specificity of Amylosucrase from the Bacterium Deinococcus geothermalis by Guérin, Frédéric, Barbe, Sophie, Pizzut-Serin, Sandra, Potocki-Véronèse, Gabrielle, Guieysse, David, Guillet, Valérie, Monsan, Pierre, Mourey, Lionel, Remaud-Siméon, Magali, André, Isabelle, Tranier, Samuel

“…Amylosucrases are sucrose-utilizing α-transglucosidases that naturally catalyze the synthesis of α-glucans, linked exclusively through α1,4-linkages. Side…”
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Structural bases for N-glycan processing by mannoside phosphorylase by Ladevèze, Simon, Cioci, Gianluca, Roblin, Pierre, Mourey, Lionel, Tranier, Samuel, Potocki-Véronèse, Gabrielle

“…The first crystal structure of Uhgb_MP, a β‐1,4‐mannopyranosyl‐chitobiose phosphorylase belonging to the GH130 family which is involved in N‐glycan degradation…”
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Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes by Garcia-Alles, Luis F, Giacometti, Gaelle, Versluis, Cees, Maveyraud, Laurent, de Paepe, Diane, Guiard, Julie, Tranier, Samuel, Gilleron, Martine, Prandi, Jacques, Hanau, Daniel, Heck, Albert J.R, Mori, Lucia, De Libero, Gennaro, Puzo, Germain, Mourey, Lionel, de la Salle, Henri

“…CD1e is the only human CD1 protein existing in soluble form in the late endosomes of dendritic cells, where it facilitates the processing of glycolipid…”
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Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae by Deng, Xu, Petitjean, Marjorie, Teste, Marie-Ange, Kooli, Wafa, Tranier, Samuel, François, Jean Marie, Parrou, Jean-Luc

“…•Isomaltases (Imap) preferably cleave α-(1,6) bonds, yet show clear substrate ambiguity.•With only 3 different aa, Ima3p activities and thermostability diverge…”
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A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli by Perrody, Elsa, Cirinesi, Anne-Marie, Desplats, Carine, Keppel, France, Schwager, Françoise, Tranier, Samuel, Georgopoulos, Costa, Genevaux, Pierre

“…The universally conserved J-domain proteins (JDPs) are obligate cochaperone partners of the Hsp70 (DnaK) chaperone. They stimulate Hsp70's ATPase activity,…”
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RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation by Demongin, Clément, Tranier, Samuel, Joshi, Vandana, Ceschi, Léa, Desforges, Bénédicte, Pastré, David, Hamon, Loic

“…FUS and TDP-43 are two self-adhesive aggregation-prone mRNA-binding proteins whose pathological mutations have been linked to neurodegeneration. While TDP-43…”
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Structural Insights into the Carbohydrate Binding Ability of an α-(1→2) Branching Sucrase from Glycoside Hydrolase Family 70 by Brison, Yoann, Malbert, Yannick, Czaplicki, Georges, Mourey, Lionel, Remaud-Simeon, Magali, Tranier, Samuel

“…The α-(1→2) branching sucrase ΔN123-GBD-CD2 is a transglucosylase belonging to glycoside hydrolase family 70 (GH70) that catalyzes the transfer of d-glucosyl…”
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HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II : A singular structure for a unique function by Bories, Pascaline, Rima, Julie, Tranier, Samuel, Marcoux, Julien, Grimoire, Yasmina, Tomaszczyk, Mathilde, Launay, Anne, Fata, Karine, Marrakchi, Hedia, Burlet-Schiltz, Odile, Mourey, Lionel, Ducoux-Petit, Manuelle, Bardou, Fabienne, Bon, Cécile, Quémard, Annaïk

“…Abstract Worldwide, tuberculosis is the second leading infectious killer and multidrug resistance severely hampers disease control. Mycolic acids are a unique…”
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Exploring the Conformational States and Rearrangements of Yarrowia lipolytica Lipase by Bordes, Florence, Barbe, Sophie, Escalier, Pierre, Mourey, Lionel, André, Isabelle, Marty, Alain, Tranier, Samuel

“…We report the 1.7 Å resolution crystal structure of the Lip2 lipase from Yarrowia lipolytica in its closed conformation. The Lip2 structure is highly…”
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Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis by Le, Nguyen-Hung, Constant, Patricia, Tranier, Samuel, Nahoum, Virginie, Guillet, Valérie, Maveyraud, Laurent, Daffé, Mamadou, Mourey, Lionel, Verhaeghe, Pierre, Marrakchi, Hedia

“…[Display omitted] Tuberculosis (TB) remains a global health crisis, further exacerbated by the slow pace of new treatment options, and the emergence of extreme…”
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HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function by Bories, Pascaline, Rima, Julie, Tranier, Samuel, Marcoux, Julien, Grimoire, Yasmina, Tomaszczyk, Mathilde, Launay, Anne, Fata, Karine, Marrakchi, Hedia, Burlet‐Schiltz, Odile, Mourey, Lionel, Ducoux‐Petit, Manuelle, Bardou, Fabienne, Bon, Cécile, Quémard, Annaïk

“…Worldwide, tuberculosis is the second leading infectious killer and multidrug resistance severely hampers disease control. Mycolic acids are a unique category…”
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Functional and Structural Characterization of α-(1→2) Branching Sucrase Derived from DSR-E Glucansucrase by Brison, Yoann, Pijning, Tjaard, Malbert, Yannick, Fabre, Émeline, Mourey, Lionel, Morel, Sandrine, Potocki-Véronèse, Gabrielle, Monsan, Pierre, Tranier, Samuel, Remaud-Siméon, Magali, Dijkstra, Bauke W.

“…ΔN123-glucan-binding domain-catalytic domain 2 (ΔN123-GBD-CD2) is a truncated form of the bifunctional glucansucrase DSR-E from Leuconostoc mesenteroides NRRL…”
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Directed evolution of SecB chaperones toward toxin-antitoxin systems by Sala, Ambre Julie, Bordes, Patricia, Ayala, Sara, Slama, Nawel, Tranier, Samuel, Coddeville, Michèle, Cirinesi, Anne-Marie, Castanié-Cornet, Marie-Pierre, Mourey, Lionel, Genevaux, Pierre

“…SecB chaperones assist protein export in bacteria. However, certain SecB family members have diverged to become specialized toward the control of…”
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Neutral Genetic Drift-Based Engineering of a Sucrose-Utilizing Enzyme toward Glycodiversification by Daudé, David, Vergès, Alizée, Cambon, Emmanuelle, Emond, Stéphane, Tranier, Samuel, André, Isabelle, Remaud-Siméon, Magali

“…Neutral drift (also called purifying selection) is an attractive approach to generate polymorphic variant libraries for enzyme engineering. Here, we have…”
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Engineering of anp efficient mutant of Neisseria polysaccharea amylosucrase for the synthesis of controlled size maltooligosaccharides by Vergès, Alizée, Barbe, Sophie, Cambon, Emmanuelle, Moulis, Claire, Tranier, Samuel, Remaud-Siméon, Magali, André, Isabelle

“…•Amylosucrase engineering led to an efficient mutant for oligosaccharide synthesis.•Synthesis of controlled-size soluble maltooligosaccharides…”
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First Structural Insights into α-l-Arabinofuranosidases from the Two GH62 Glycoside Hydrolase Subfamilies by Siguier, Béatrice, Haon, Mireille, Nahoum, Virginie, Marcellin, Marlène, Burlet-Schiltz, Odile, Coutinho, Pedro M., Henrissat, Bernard, Mourey, Lionel, O'Donohue, Michael J., Berrin, Jean-Guy, Tranier, Samuel, Dumon, Claire

“…α-l-Arabinofuranosidases are glycoside hydrolases that specifically hydrolyze non-reducing residues from arabinose-containing polysaccharides. In the case of…”
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Applying Pairwise Combinations of Amino Acid Mutations for Sorting Out Highly Efficient Glucosylation Tools for Chemo-Enzymatic Synthesis of Bacterial Oligosaccharides by Champion, Elise, Guérin, Frédéric, Moulis, Claire, Barbe, Sophie, Tran, Thu Hoai, Morel, Sandrine, Descroix, Karine, Monsan, Pierre, Mourey, Lionel, Mulard, Laurence A, Tranier, Samuel, Remaud-Siméon, Magali, André, Isabelle

“…Iterative saturation mutagenesis and combinatorial active site saturation focused on vicinal amino acids were used to alter the acceptor specificity of…”
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A bacteriophage-encoded J-domain protein interacts with the DnaK /Hsp70 chaperone and stabilizes the heat-shock factor [σ.sup.32] of Escherichia coli by Perrody, Elsa, Cirinesi, Anne-Marie, Desplats, Carine, Keppel, France, Schwager, Francoise, Tranier, Samuel, Georgopoulos, Costa, Genevaux, Pierre

“…The universally conserved J-domain proteins (JDPs) are obligate cochaperone partners of the Hsp70 (DnaK) chaperone. They stimulate Hsp70's ATPase activity,…”
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A Bacteriophage-Encoded J-Domain Protein Interacts with the DnaK/Hsp70 Chaperone and Stabilizes the Heat-Shock Factor [sigma]32 of Escherichia coli by Perrody, Elsa, Cirinesi, Anne-Marie, Desplats, Carine, Keppel, France, Schwager, Françoise, Tranier, Samuel, Georgopoulos, Costa, Genevaux, Pierre

“…The universally conserved J-domain proteins (JDPs) are obligate cochaperone partners of the Hsp70 (DnaK) chaperone. They stimulate Hsp70's ATPase activity,…”
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'pair of sugar tongs' site on the non-catalytic domain C of barley α-amylase participates in substrate binding and activity by Bozonnet, Sophie, Jensen, Morten T, Nielsen, Morten M, Aghajari, Nushin, Jensen, Malene H, Kramhøft, Birte, Willemoës, Martin, Tranier, Samuel, Haser, Richard, Svensson, Birte

“…Some starch-degrading enzymes accommodate carbohydrates at sites situated at a certain distance from the active site. In the crystal structure of barley…”
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