Search Results - "Trang, Phong"

Engineering of RNase P Ribozymes for Therapy against Human Cytomegalovirus Infection by Smith, Adam, Zhang, Isadora, Trang, Phong, Liu, Fenyong

“…Nucleic acid-based gene interference and editing strategies, such as antisense oligonucleotides, ribozymes, RNA interference (RNAi), and CRISPR/Cas9 coupled…”
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Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice by Trang, Phong, Wiggins, Jason F, Daige, Christopher L, Cho, Chris, Omotola, Michael, Brown, David, Weidhaas, Joanne B, Bader, Andreas G, Slack, Frank J

“…MicroRNAs (miRNAs) are emerging as potential cancer therapeutics, but effective delivery mechanisms to tumor sites are a roadblock to utility. Here we show…”
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Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections by Chen, Yuan-Chuan, Sheng, Jingxue, Trang, Phong, Liu, Fenyong

“…The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus,…”
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The let-7 microRNA reduces tumor growth in mouse models of lung cancer by Esquela-Kerscher, Aurora, Trang, Phong, Wiggins, Jason F., Patrawala, Lubna, Cheng, Angie, Ford, Lance, Weidhaas, Joanne Barnes, Brown, David, Bader, Andreas G., Slack, Frank J.

“…MicroRNAs have been increasingly implicated in human cancer and interest has grown about the potential to use microRNAs to combat cancer. Lung cancer is the…”
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MicroRNAs as Potential Agents to Alter Resistance to Cytotoxic Anticancer Therapy by WEIDHAAS, Joanne B, BABAR, Imran, NALLUR, Sunitha M, TRANG, Phong, ROUSH, Sarah, BOEHM, Michelle, GILLESPIE, Erin, SLACK, Frank J

“…Tumor cells use preexisting prosurvival signaling pathways to evade the damaging and cytotoxic effects of anticancer agents. Radiation therapy is a primary…”
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Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein by Feng, Linyuan, Sheng, Jingxue, Vu, Gia-Phong, Liu, Yujun, Foo, Chingman, Wu, Songbin, Trang, Phong, Paliza-Carre, Marco, Ran, Yanhong, Yang, Xiaoping, Sun, Xu, Deng, Zemin, Zhou, Tianhong, Lu, Sangwei, Li, Hongjian, Liu, Fenyong

“…Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human…”
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Inhibition of human cytomegalovirus major capsid protein expression and replication by ribonuclease P-associated external guide sequences by Deng, Qiudi, Liu, Yujun, Li, Xin, Yan, Bin, Sun, Xu, Tang, Wei, Trang, Phong, Yang, Zhu, Gong, Hao, Wang, Yu, Lu, Jie, Chen, Jun, Xia, Chuan, Xing, Xiwen, Lu, Sangwei, Liu, Fenyong

“…External guide sequences (EGSs) signify the short RNAs that induce ribonuclease P (RNase P), an enzyme responsible for processing the 5' termini of tRNA, to…”
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Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development by Liu, Wei, Dai, Xinghong, Jih, Jonathan, Chan, Karen, Trang, Phong, Yu, Xuekui, Balogun, Rilwan, Mei, Ye, Liu, Fenyong, Zhou, Z Hong

“…Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more…”
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Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals by Li, Wei, Liu, Yujun, Wang, Yuanyuan, Li, Ruilin, Trang, Phong, Tang, Wei, Yang, Zhu, Wang, Yu, Sun, Xu, Xing, Xiwen, Lu, Sangwei, Liu, Fenyong

“…Gene-targeting ribozymes represent promising nucleic acid-based gene interference agents for therapeutic application. We previously used an selection procedure…”
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Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012 by Liu, Michelle Y., Liu, Jin, Lai, Weijian, Luo, Jun, Liu, Yingle, Vu, Gia-Phong, Yang, Zhu, Trang, Phong, Li, Hongjian, Wu, Jianguo

“…Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of…”
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Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant by Sun, Xu, Chen, Weijie, He, Lingling, Sheng, Jingxue, Liu, Yujun, Vu, Gia-Phong, Yang, Zhu, Li, Wei, Trang, Phong, Wang, Yu, Hai, Rong, Zhu, Hua, Lu, Sangwei, Liu, Fenyong

“…We have previously engineered new RNase P-based ribozyme variants with improved in vitro catalytic activity. In this study, we employed a novel engineered…”
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The Grading Entropy-based Criteria for Structural Stability of Granular Materials and Filters by Janos Lőrincz, Emöke Imre, Stephen Fityus, Phong Q. Trang, Tibor Tarnai, István Talata, Vijay P. Singh

“…This paper deals with three grading entropy-based rules that describe different soil structure stability phenomena: an internal stability rule, a filtering…”
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Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme by Zeng, Wenbo, Chen, Yuan-Chuan, Bai, Yong, Trang, Phong, Vu, Gia-Phong, Lu, Sangwei, Wu, Jianguo, Liu, Fenyong

“…Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study,…”
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Inhibition of Murine Cytomegalovirus Infection in Animals by RNase P-Associated External Guide Sequences by Li, Wei, Sheng, Jingxue, Xu, Mengqiong, Vu, Gia-Phong, Yang, Zhu, Liu, Yujun, Sun, Xu, Trang, Phong, Lu, Sangwei, Liu, Fenyong

“…External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting…”
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Effective inhibition of cytomegalovirus infection by external guide sequences in mice by Jiang, Xiaohong, Gong, Hao, Chen, Yuan-Chuan, Vu, Gia-Phong, Trang, Phong, Zhang, Chen-Yu, Lu, Sangwei, Liu, Fenyong

“…Ribonuclease P complexed with external guide sequence (EGS) bound to mRNA represents a unique nucleic acid-based gene interference approach for modulation of…”
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Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA by Bai, Yong, Trang, Phong, Li, Hongjian, Kim, Kihoon, Zhou, Tianhong, Liu, Fenyong

“…A functional RNase P ribozyme (M1GS RNA) was constructed to target the overlapping mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential…”
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RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins by Yang, Zhu, Reeves, Michael, Ye, Jun, Trang, Phong, Zhu, Li, Sheng, Jingxue, Wang, Yu, Zen, Ke, Wu, Jianguo, Liu, Fenyong

“…An engineered RNase P-based ribozyme variant, which was generated using the in vitro selection procedure, was used to target the overlapping mRNA region of two…”
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RNase P-Associated External Guide Sequence Effectively Reduces the Expression of Human CC-Chemokine Receptor 5 and Inhibits the Infection of Human Immunodeficiency Virus 1 by Liu, Fenyong, Lu, Sangwei, Trang, Phong, Chen, Yuan-Chuan, Bai, Yong, Vu, Gia-Phong, Zeng, Wenbo, Xiao, Gengfu

“…External guide sequences (EGSs) represent a new class of RNA-based gene-targeting agents, consist of a sequence complementary to a target mRNA, and render the…”
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Ribonuclease P-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences by Jiang, Xiaohong, Chen, Yuan-Chuan, Gong, Hao, Trang, Phong, Lu, Sangwei, Liu, Fenyong

“…External guide sequences (EGSs) are RNA molecules that can bind to a target mRNA and direct ribonuclease P (RNase P), a tRNA processing enzyme, for specific…”
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Case Studies and Benchmark Examples for the Use of Grading Entropy in Geotechnics by Vijay P. Singh, Stephen Fityus, Laszlo Nagy, Phong Q. Trang, Emöke Imre, Jànos Lörincz, Janos Szendefy

“…The grading entropy concept can be adapted to the field of geotechnics, to establish criteria for phenomena such as particle packing, particle migration and…”
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