Search Results - "Tran, Ngoc Tung"

The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation by Tran, Ngoc-Tung, Su, Hairui, Khodadadi-Jamayran, Alireza, Lin, Shan, Zhang, Li, Zhou, Dewang, Pawlik, Kevin M, Townes, Tim M, Chen, Yabing, Mulloy, James C, Zhao, Xinyang

“…Antisense RNAs regulate the transcription and translation of the corresponding sense genes. Here, we report that an antisense RNA, AS‐RBM15, is transcribed in…”
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Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing by Zhang, Li, Tran, Ngoc-Tung, Su, Hairui, Wang, Rui, Lu, Yuheng, Tang, Haiping, Aoyagi, Sayura, Guo, Ailan, Khodadadi-Jamayran, Alireza, Zhou, Dewang, Qian, Kun, Hricik, Todd, Côté, Jocelyn, Han, Xiaosi, Zhou, Wenping, Laha, Suparna, Abdel-Wahab, Omar, Levine, Ross L, Raffel, Glen, Liu, Yanyan, Chen, Dongquan, Li, Haitao, Townes, Tim, Wang, Hengbin, Deng, Haiteng, Zheng, Y George, Leslie, Christina, Luo, Minkui, Zhao, Xinyang

“…RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine…”
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Methylation of dual-specificity phosphatase 4 controls cell differentiation by Su, Hairui, Jiang, Ming, Senevirathne, Chamara, Aluri, Srinivas, Zhang, Tuo, Guo, Han, Xavier-Ferrucio, Juliana, Jin, Shuiling, Tran, Ngoc-Tung, Liu, Szu-Mam, Sun, Chiao-Wang, Zhu, Yongxia, Zhao, Qing, Chen, Yuling, Cable, LouAnn, Shen, Yudao, Liu, Jing, Qu, Cheng-Kui, Han, Xiaosi, Klug, Christopher A., Bhatia, Ravi, Chen, Yabing, Nimer, Stephen D., Zheng, Y. George, Iancu-Rubin, Camelia, Jin, Jian, Deng, Haiteng, Krause, Diane S., Xiang, Jenny, Verma, Amit, Luo, Minkui, Zhao, Xinyang

“…Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell…”
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Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system by Tran, Ngoc-Tung, Trinh, Quynh-Mai, Lee, Gyun Min, Han, Yong-Mahn

“…Mesenchymal stem cells (MSCs) derived from human pluripotent stem cells (hPSC-derived MSCs) will be one promising alternative cell source for MSC-based…”
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Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro by Park, Sang-Wook, Kim, Jihoon, Park, Jong-Lyul, Ko, Ji-Yun, Im, Ilkyun, Do, Hyo-Sang, Kim, Hyemin, Tran, Ngoc-Tung, Lee, Sang-Hun, Kim, Yong Sung, Cho, Yee Sook, Lee, Dong Ryul, Han, Yong-Mahn

“…•Imprinted genes represent differential allelic expression patterns in hPSCs.•Some imprinted genes are conserved in the allelic expression during…”
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Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line by Chu, Van Trung, Graf, Robin, Wirtz, Tristan, Weber, Timm, Favret, Jeremy, Li, Xun, Petsch, Kerstin, Tran, Ngoc Tung, Sieweke, Michael H., Berek, Claudia, Kühn, Ralf, Rajewsky, Klaus

“…Applying clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9)-mediated mutagenesis to primary mouse immune…”
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CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia by Tran, Ngoc Tung, Graf, Robin, Wulf-Goldenberg, Annika, Stecklum, Maria, Strauß, Gabriele, Kühn, Ralf, Kocks, Christine, Rajewsky, Klaus, Chu, Van Trung

“…Severe congenital neutropenia (SCN) is a monogenic disorder. SCN patients are prone to recurrent life-threatening infections. The main causes of SCN are…”
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Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors by Tran, Ngoc-Tung, Bashir, Sanum, Li, Xun, Rossius, Jana, Chu, Van Trung, Rajewsky, Klaus, Kühn, Ralf

“…The CRISPR-Cas9 system is used for genome editing in mammalian cells by introducing double-strand breaks (DSBs) which are predominantly repaired via…”
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Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma by Nguyen, Hong Phuong, Le, Anh Quynh, Liu, Enze, Cesarano, Annamaria, DiMeo, Francesco, Perna, Fabiana, Kapur, Reuben, Walker, Brian A, Tran, Ngoc Tung

“…Multiple myeloma (MM) is a devastating plasma cell malignancy characterized by the expansion of aberrant monoclonal plasma cells in the bone marrow, leading to…”
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Corrigendum: Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma by Nguyen, Hong Phuong, Le, Anh Quynh, Liu, Enze, Cesarano, Annamaria, DiMeo, Francesco, Perna, Fabiana, Kapur, Reuben, Walker, Brian A., Tran, Ngoc Tung

“…[This corrects the article DOI: 10.3389/fimmu.2023.1239614.]…”
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Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells by Tran, Ngoc Tung, Sommermann, Thomas, Graf, Robin, Trombke, Janine, Pempe, Jenniffer, Petsch, Kerstin, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung

“…Mutations accumulating in hematopoietic stem and progenitor cells (HSPCs) during development can cause severe hematological disorders. Modeling these mutations…”
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Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells by Tran, Ngoc Tung, Danner, Eric, Li, Xun, Graf, Robin, Lebedin, Mikhail, de la Rosa, Kathrin, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung

“…While CRISPR-Cas9 is key for the development of gene therapy, its potential off-target mutations are still a major concern. Here, we establish a "spacer-nick"…”
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Efficient and Precise CRISPR/Cas9-Mediated MECP2 Modifications in Human-Induced Pluripotent Stem Cells by Le, Thi Thanh Huong, Tran, Ngoc Tung, Dao, Thi Mai Lan, Nguyen, Dinh Dung, Do, Huy Duong, Ha, Thi Lien, Kühn, Ralf, Nguyen, Thanh Liem, Rajewsky, Klaus, Chu, Van Trung

“…Patients with Rett syndrome (RTT) have severe mental and physical disabilities. The majority of RTT patients carry a heterozygous mutation in methyl-CpG…”
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Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells by Tran, Ngoc Tung, Trombke, Janine, Rajewsky, Klaus, Chu, Van Trung

“…Mutations that accumulate in self-renewing hematopoietic stem and progenitor cells (HSPCs) can cause severe blood disorders. To model such disorders in mice,…”
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Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety by Tran, Ngoc Tung, Lebedin, Mikhail, Danner, Eric, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung

“…The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive…”
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Corrigendum: Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors by Tran, Ngoc-Tung, Bashir, Sanum, Li, Xun, Rossius, Jana, Chu, Van Trung, Rajewsky, Klaus, Kühn, Ralf

“…[This corrects the article DOI: 10.3389/fgene.2019.00365.]…”
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Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1 by Jin, Shuiling, Su, Hairui, Tran, Ngoc-Tung, Song, Jing, Lu, Sydney S, Li, Ying, Huang, Suming, Abdel-Wahab, Omar, Liu, Yanyan, Zhao, Xinyang

“…More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in…”
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Rapidly evolving genome and epigenome editing technologies by Tran, Ngoc Tung, Han, Renzhi

“…Genome editing technologies are rapidly evolving, from the early zinc-finger nucleases, transcription activator-like effector nucleases (TALENs), and…”
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The Oligosaccharyltransferase Complex: A Novel Vulnerability in Multiple Myeloma by Nguyen, Hong Phuong, Le, Anh Quynh, Liu, Enze, Walker, Brian A., Tran, Ngoc Tung

“…Abstract Multiple myeloma (MM) is described as a clonal expansion of malignant plasma cells in the bone marrow characterized by several clinical symptoms: bone…”
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Synergistic Effects of Type I PRMT1 and Type II PRMT5 Inhibitors Against Multiple Myeloma by Nguyen, Hong Phuong, Liu, Enze, Walker, Brian A., Tran, Ngoc Tung

“…Multiple myeloma (MM) is a plasma cell malignancy characterized by the extensive expansion of monoclonal aberrant plasma cells in the bone marrow and the…”
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