Search Results - "Tran, Hoanh"

Reversible Modification of Adenomatous Polyposis Coli (APC) with K63-linked Polyubiquitin Regulates the Assembly and Activity of the β-Catenin Destruction Complex by Tran, Hoanh, Polakis, Paul

“…The adenomatous polyposis coli (APC) tumor suppressor forms a complex with Axin and GSK3β to promote the phosphorylation and degradation of β-catenin, a key…”
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Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth by Frank, Daniel, Bergamasco, Maria, Mlodzianoski, Michael J, Kueh, Andrew, Tsui, Ellen, Hall, Cathrine, Kastrappis, Georgios, Voss, Anne Kathrin, McLean, Catriona, Faux, Maree, Rogers, Kelly L, Tran, Bang, Vincan, Elizabeth, Komander, David, Dewson, Grant, Tran, Hoanh

“…(human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid…”
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Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells by Tögel, Lars, Nightingale, Rebecca, Chueh, Anderly C, Jayachandran, Aparna, Tran, Hoanh, Phesse, Toby, Wu, Rui, Sieber, Oliver M, Arango, Diego, Dhillon, Amardeep S, Dawson, Mark A, Diez-Dacal, Beatriz, Gahman, Timothy C, Filippakopoulos, Panagis, Shiau, Andrew K, Mariadason, John M

“…Inhibitors of the bromodomain and extraterminal domain (BET) protein family attenuate the proliferation of several tumor cell lines. These effects are…”
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Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling by Callow, Marinella G, Tran, Hoanh, Phu, Lilian, Lau, Ted, Lee, James, Sandoval, Wendy N, Liu, Peter S, Bheddah, Sheila, Tao, Janet, Lill, Jennie R, Hongo, Jo-Anne, Davis, David, Kirkpatrick, Donald S, Polakis, Paul, Costa, Mike

“…Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that…”
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Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells by Diesch, Jeannine, Sanij, Elaine, Gilan, Omer, Love, Christopher, Tran, Hoanh, Fleming, Nicholas I, Ellul, Jason, Amalia, Marcia, Haviv, Izhak, Pearson, Richard B, Tulchinsky, Eugene, Mariadason, John M, Sieber, Oliver M, Hannan, Ross D, Dhillon, Amardeep S

“…Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is…”
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Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 by Tran, Hoanh, Maurer, Fabienne, Nagamine, Yoshikuni

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling by Tran, Bang Manh, Flanagan, Dustin James, Ebert, Gregor, Warner, Nadia, Tran, Hoanh, Fifis, Theodora, Kastrappis, Georgios, Christophi, Christopher, Pellegrini, Marc, Torresi, Joseph, Phesse, Toby James, Vincan, Elizabeth

“…An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection with hepatitis B virus (HBV) is…”
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HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction by Tran, Hoanh, Bustos, Daisy, Yeh, Ronald, Rubinfeld, Bonnee, Lam, Cynthia, Shriver, Stephanie, Zilberleyb, Inna, Lee, Michelle W., Phu, Lilian, Sarkar, Anjali A., Zohn, Irene E., Wertz, Ingrid E., Kirkpatrick, Donald S., Polakis, Paul

“…The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wnt signaling pathway. In this capacity, APC forms a “destruction…”
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In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose by Dong, Li, Reljic, Boris, Cheung, Jen G., Ng, Elizabeth S., Lindqvist, Lisa M., Elefanty, Andrew G., Vaux, David L., Tran, Hoanh

“…Withdrawal of the growth factor interleukin-3 (IL-3) from IL-3-dependent myeloid cells causes them to undergo Bax/Bak1-dependent apoptosis, whereas…”
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The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent Manner by Shin, Joongho, Carr, Azadeh, Corner, Georgia A., Tögel, Lars, Dávaos-Salas, Mercedes, Tran, Hoanh, Chueh, Anderly C., Al-Obaidi, Sheren, Chionh, Fiona, Ahmed, Naseem, Buchanan, Daniel D., Young, Joanne P., Malo, Madhu S., Hodin, Richard A., Arango, Diego, Sieber, Oliver M., Augenlicht, Leonard H., Dhillon, Amardeep S., Weber, Thomas K., Mariadason, John M.

“…The histone deacetylase inhibitor (HDACi) sodium butyrate promotes differentiation of colon cancer cells as evidenced by induced expression and enzyme activity…”
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APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration by Ekman, Maria, Mu, Yabing, Lee, So Young, Edlund, Sofia, Kozakai, Takaharu, Thakur, Noopur, Tran, Hoanh, Qian, Jiang, Groeden, Joanna, Heldin, Carl-Henrik, Landström, Maréne

“…Cell migration occurs by activation of complex regulatory pathways that are spatially and temporally integrated in response to extracellular cues. Binding of…”
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Facilitation of mRNA Deadenylation and Decay by the Exosome-Bound, DExH Protein RHAU by Tran, Hoanh, Schilling, Marcel, Wirbelauer, Christiane, Hess, Daniel, Nagamine, Yoshikuni

“…The AU-rich element (ARE) in the 3′ untranslated region of unstable mRNAs mediate their rapid degradation. ARE binding proteins (AUBPs) have been described…”
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K‐Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines by Yeung, Yvonne, Lau, David K., Chionh, Fiona, Tran, Hoanh, Tse, Janson W. T., Weickhardt, Andrew J., Nikfarjam, Mehrdad, Scott, Andrew M., Tebbutt, Niall C., Mariadason, John M.

“…Advanced biliary tract cancer (BTC) has a poor prognosis and limited treatment options. The PI3K/Akt/mTOR signalling pathway is hyperactivated in a subset of…”
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Combined Gap-Polymerase Chain Reaction and Targeted Next-Generation Sequencing Improve α- and β-Thalassemia Carrier Screening in Pregnant Women in Vietnam by Lam, Tuan-Thanh, Nguyen, Doan-Tu, Le, Quang Thanh, Nguyen, Duy-Anh, Hoang, Diem-Tuyet Thi, Nguyen, Huu Du, Nguyen, Canh Chuong, Doan, Kim Phuong Thi, Tran, Nhat-Thang, Ha, Thi Minh Thi, Trinh, Thu Huong Nhat, Nguyen, Van Thong, Lam, Duc Tam, Le, Minh Tam, Nguyen, Xuan Thao, Ho, Thu-Hang Thi, Tran, Trung Hoanh, Ho, Viet Thang, Bui, Thanh Van, Nguyen, Van Trong, Hoang, Phuoc Ba, Nguyen, Hoai Thanh, Nguyen, Manh Hoan, Vo, Thanh-Binh, Le, Duy-Khang Nguyen, Truong, Thao Ngoc, Dao, Hong-Thuy Thi, Vo, Phuong-Anh Ngoc, Nguyen, Thien-Chi Van, Tran, Ngoc-Nhu Thi, Tran, Quynh-Nhu Thi, Van, Yen-Linh Thi, Nguyen, Thanh-Thanh Thi, Huynh, Bich-Ngoc Thi, Nguyen, Thanh-Phuong Thi, Tran, Kim-Van Thi, Nguyen, Cong-Trai, Doan, Phuoc-Loc, Nguyen, Thanh-Dat, Do, Thanh-Thuy Thi, Truong, Dinh-Kiet, Tang, Hung Sang, Cao, Ngoc-Phuong Thi, Phan, Minh-Duy, Giang, Hoa, Nguyen, Hoai-Nghia

“…Vietnam has a high thalassemia burden. We collected blood samples from 5880 pregnant Vietnamese women during prenatal health checks to assess thalassemia…”
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Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains by Tran, Hoanh, Hamada, Fumihiko, Schwarz-Romond, Thomas, Bienz, Mariann

“…A key effector of the canonical Wnt pathway is beta-catenin, which binds to TCF/LEF factors to promote the transcription of Wnt target genes. In the absence of…”
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Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth by Frank, Daniel, Bergamasco, Maria, Mlodzianoski, Michael J, Kueh, Andrew, Tsui, Ellen, Hall, Cathrine, Kastrappis, Georgios, Voss, Anne Kathrin, McLean, Catriona, Faux, Maree, Rogers, Kelly L, Tran, Bang, Vincan, Elizabeth, Komander, David, Dewson, Grant, Tran, Hoanh

“…ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how…”
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Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer by Luk, Ian Y., Tran, Hoanh, Tse, Janson W., Chueh, Anderly C., Chionh, Fiona, Clemons, Nicholas J., Mariadason, John M.

“…Abstract Background: Colon cancer is a leading cause of cancer related death. Colon cancer arises due to uncontrolled cell proliferation, failure of cells to…”
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Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN by Tse, Janson W., Chueh, Anderly C., Luk, Ian Y., Chionh, Fiona, Yeung, Yvonne, Corner, Georgia A., Ng, Dominic C., Tran, Hoanh, Dhillon, Amardeep S., Mariadason, John M.

“…Abstract Background/Aim: Histone deacetylase inhibitors (HDACi) are approved for the treatment of cutaneous T-cell lymphoma. We have previously demonstrated…”
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Phase II study of everolimus monotherapy as first-line treatment in advanced biliary tract cancer: RADichol by Yeung, Yvonne H., Chionh, Fiona J.M., Price, Timothy Jay, Scott, Andrew Mark, Tran, Hoanh, Fang, Guangying, Skrinos, Effie, Murone, Carmel, Mariadason, John M, Tebbutt, Niall C.

“…Abstract only…”
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The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner by Shin, Joongho, Carr, Azadeh, Corner, Georgia A., Tögel, Lars, Dávalos-Salas, Mercedes, Tran, Hoanh, Chueh, Anderly C., Al-Obaidi, Sheren, Chionh, Fiona, Ahmed, Naseem, Buchanan, Daniel D., Young, Joanne P., Malo, Madhu S., Hodin, Richard A., Arango, Diego, Sieber, Oliver M., Augenlicht, Leonard H., Dhillon, Amardeep S., Weber, Thomas K., Mariadason, John M.

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