Neuroimaging Appearance of Cerebral Malignant Epithelioid Glioneuronal Tumors in Children

Malignant epithelioid glioneuronal tumor is a rare high-grade, aggressive brain tumor that shows both glial and neuronal differentiation on histopathology but is not included in the current World Health Organization classification. The neuroimaging appearance is variable but may be secondary to the...

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Bibliographic Details
Published in:	American journal of neuroradiology : AJNR Vol. 41; no. 9; pp. 1740 - 1744
Main Authors:	Orman, G, Mohammed, S, Tran, H D B, Lin, F Y, Meoded, A, Desai, N, Huisman, T A G M, Kralik, S F
Format:	Journal Article
Language:	English
Published:	United States American Society of Neuroradiology 01-09-2020
Subjects:	Adolescent Child Child, Preschool Female Ganglioglioma - diagnostic imaging Ganglioglioma - pathology Humans Male Neuroimaging - methods Pediatrics Supratentorial Neoplasms - diagnostic imaging Supratentorial Neoplasms - pathology
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Summary:	Malignant epithelioid glioneuronal tumor is a rare high-grade, aggressive brain tumor that shows both glial and neuronal differentiation on histopathology but is not included in the current World Health Organization classification. The neuroimaging appearance is variable but may be secondary to the size of the mass and/or location of the tumor. In our series, all epithelioid glioneuronal tumors were encountered in the supratentorial space and included pineal, temporal, and extratemporal lobar cerebral hemisphere locations. When large, the tumors demonstrate cystic degeneration and necrosis, hemorrhage, contrast enhancement, and regions of low apparent diffusion coefficient scalars consistent with patterns seen with other high-grade pediatric brain tumors. The tumors also have a propensity to spread into the meninges at presentation and for distant CSF spread on follow-up imaging.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0195-6108 1936-959X
DOI:	10.3174/ajnr.A6668