Search Results - "Trampont, Paul C."

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance by Harden, T. Kendall, Kadl, Alexandra, Ostankovich, Marina, Lazarowski, Eduardo R, Lysiak, Jeffrey J, Walk, Scott F, Ravichandran, Kodi S, Elliott, Michael R, Woodson, Robin I, Park, Daeho, Chekeni, Faraaz B, Trampont, Paul C, Sharma, Poonam, Leitinger, Norbert

“…Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with significant apoptosis, very few apoptotic cells are detectable…”
Get full text

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein by Park, Daeho, Han, Claudia Z., Elliott, Michael R., Kinchen, Jason M., Trampont, Paul C., Das, Soumita, Collins, Sheila, Lysiak, Jeffrey J., Hoehn, Kyle L., Ravichandran, Kodi S.

“…How phagocytes keep their appetite When a phagocyte engulfs a dying cell, it essentially doubles its cellular contents, yet phagocytes are capable of ingesting…”
Get full text

Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells by Kim, Taeg S, Hanak, Mark, Trampont, Paul C, Braciale, Thomas J

“…Erythropoiesis is an important response to certain types of stress, including hypoxia, hemorrhage, bone marrow suppression, and anemia, that result in…”
Get full text

Cooperation between Noncanonical Ras Network Mutations by Stites, Edward C., Trampont, Paul C., Haney, Lisa B., Walk, Scott F., Ravichandran, Kodi S.

“…Cancer develops after the acquisition of a collection of mutations that together create the cancer phenotype. How collections of mutations work together within…”
Get full text

Network Analysis of Oncogenic Ras Activation in Cancer by Stites, Edward C., Trampont, Paul C., Ma, Zhong, Ravichandran, Kodi S.

“…To investigate the unregulated Ras activation associated with cancer, we developed and validated a mathematical model of Ras signaling. The model-based…”
Get full text

Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation by Buckley, Monica W, Arandjelovic, Sanja, Trampont, Paul C, Kim, Taeg S, Braciale, Thomas J, Ravichandran, Kodi S

“…T cell development and activation are highly regulated processes, and their proper execution is important for a competent immune system. Shc SH2-domain binding…”
Get full text

Cooperation between Noncanonical Ras Network Mutations by Stites, Edward C., Trampont, Paul C., Haney, Lisa B., Walk, Scott F., Ravichandran, Kodi S.

Get full text

Best practices for the development and fit-for-purpose validation of biomarker methods: a conference report by Mathews, Joel, Amaravadi, Lakshmi, Eck, Steven, Stevenson, Lauren, Wang, Yow-Ming C., Devanarayan, Viswanath, Allinson, John, Lundsten, Kelly, Gunsior, Michele, Ni, Yan G., Pepin, Marc-Olivier, Gagnon, Audrey, Sheldon, Curtis, Trampont, Paul C., Litwin, Virginia

“…This conference report summarized a full-day workshop, “best practices for the development and fit-for-purpose validation of biomarker methods,” which was held…”
Get full text

Progress towards global standardization for quantitative flow cytometry by Gonneau, Christèle, Wang, Lili, Mitra-Kaushik, Shibani, Trampont, Paul C, Litwin, Virginia

Get full text

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 – Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62) by Piccoli, Steven, Mehta, Devangi, Vitaliti, Alessandra, Allinson, John, Amur, Shashi, Eck, Steve, Green, Cherie, Hedrick, Michael, Hopper, Shirley, Ji, Allena, Joyce, Alison, Litwin, Virginia, Maher, Kevin, Mathews, Joel, Peng, Kun, Safavi, Afshin, Wang, Yow-Ming, Zhang, Yan, Amaravadi, Lakshmi, Palackal, Nisha, Thankamony, Sai, Beaver, Chris, Bame, Eris, Emrich, Thomas, Grimaldi, Christine, Haulenbeek, Jonathan, Kakkanaiah, Vellalore, Lanham, David, Mayer, Andrew, Trampont, Paul C, Vermet, Laurent, Dakappagari, Naveen, Fleener, Catherine, Garofolo, Fabio, Rogers, Cynthia, Tangri, Shabnam, Xu, Yuanxin, Liang, Meina, Rajadhyaksha, Manoj, Richards, Susan, Schweighardt, Becky, Purushothama, Shobha, Baltrukonis, Daniel, Brumm, Jochen, Cherry, Elana, Delcarpini, Jason, Gleason, Carol, Kirshner, Susan, Kubiak, Robert, Pan, Luying, Partridge, Michael, Pedras-Vasconcelos, João, Qu, Qiang, Skibeli, Venke, Saunders, Therese Solstad, Staack, Roland F, Stubenrauch, Kay, Torri, Al, Verthelyi, Daniela, Yan, Haoheng, Gorovits, Boris, Palmer, Rachel, Milton, Mark, Long, Brian, Corsaro, Bart, Farrokhi, Vahid, Fiscella, Michele, Henderson, Neil, Jawa, Vibha, McNally, Jim, Murphy, Rocio, Waldner, Hanspeter, Yang, Tong-Yuan

“…The 2019 13 Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA, USA on April 1–5, 2019 with an attendance of over 1000…”
Get full text

CXCR4 acts as a costimulator during thymic β-selection by Ravichandran, Kodi S, Trampont, Paul C, Tosello-Trampont, Annie-Carole, Shen, Yuelei, Duley, Amanda K, Sutherland, Ann E, Bender, Timothy P, Littman, Dan R

“…Pre-TCR signaling is essential for the passage of thymocytes through the β-selection checkpoint. Ravichandran and co-workers find that CXCR4 acts as a…”
Get full text

Best practices for the development, analytical validation and clinical implementation of flow cytometric methods for chimeric antigen receptor T cell analyses by Sarikonda, Ghanashyam, Mathieu, Mélissa, Natalia, Mahwish, Pahuja, Anil, Xue, Qiong, Pierog, Piotr L., Trampont, Paul C., Decman, Vilma, Reynolds, Susan, Hanafi, Laïla‐Aïcha, Sun, Yongliang S., Eck, Steven, Hedrick, Michael N., Stewart, Jennifer J., Tangri, Shabnam, Litwin, Virginia, Dakappagari, Naveen

“…Chimeric Antigen Receptor (CAR) T cells are recognized as efficacious therapies with demonstrated ability to produce durable responses in blood cancer…”
Get full text

2023 White Paper on Recent Issues in Bioanalysis: EU IVDR 2017/746 Implementation/Impact, IVD/CDx/CLIA Approved Assays, High Dimensional Cytometry, Multiplexing Technologies, LBA Tissue Analysis, Vaccine Study Endpoints, Cell-Based Assays for Biomarkers, Cell Therapy and Vaccines ( PART 2 - Recommendations on Development & Validation of Biomarkers, IVD, CDx, Cell-Based, Flow Cytometry, Ligand-Binding and Enzyme Assays; Advanced Critical Reagents Strategies) by Kholmanskikh, Olga, Wang, Yow-Ming, Hersey, Sarah, Wadhwa, Meenu, Block, Katherine, Bandukwala, Abbas, Szapacs, Matthew, Weiner, Russell, Awwad, Khader, Dessy, Francis, Downing, Sean, Du, Xiulian, Garofolo, Fabio, Harris, Shannon, Hou, Victor, Jones, Jennifer, Kar, Sumit, Kinhikar, Arvind, Li, Ming, Mathews, Joel, Meissen, John, Sumner, Giane Oliveira, Pan, Luying, Sanderink, Gerard, Scully, Ingrid, Stanta, Johannes, Tanaka, Yoichi, Vauleon, Stephanie, Wagner, Leslie, Wang, Kai, Zhu, Liang, Eck, Steven, Lin, Yi-Dong, Azadeh, Mitra, Decman, Vilma, Diebold, Sandra, Goihberg, Polina, Alcaide, Enrique Gomez, Gonneau, Christele, Hedrick, Michael Nathan, Hopkins, Gregory, Loschko, Jakob, McCausland, Megan, Mendez, Luis, Sehra, Sarita, Stevens, Erin, Sun, Yongliang Steve, Tangri, Shabnam, Trampont, Paul C, Cludts, Isabelle, Dysinger, Mark, Kavita, Uma, Sugimoto, Hiroshi, Chilewski, Shannon, Grimaldi, Christine, Jiang, Yong, Kamerud, John, Liu, Susana, Owen, Carolina, Palackal, Nisha, Petit-Frere, Corinne, Pine, Samuel, Abhari, Mohsen Rajabi, Scheibner, Kara, Williams, LaKenya, Xu, Tao, Zhang, Guodong

“…The 17 Workshop on Recent Issues in Bioanalysis (17 WRIB) took place in Orlando, FL, USA on 19-23 June 2023. Over 1000 professionals representing…”
Get more information

ShcA Regulates Thymocyte Proliferation through Specific Transcription Factors and a c-Abl-Dependent Signaling Axis by Trampont, Paul C., Zhang, Li, Giles, Amber J., Walk, Scott F., Gu, Jing J., Pendergast, Ann Marie, Ravichandran, Kodi S.

“…Signaling via the pre-T-cell receptor (pre-TCR), along with associated signals from Notch and chemokine receptors, regulates the β-selection checkpoint that…”
Get full text

ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers by Buckley, Monica W, Trampont, Paul C, Arandjelovic, Sanja, Fond, Aaron M, Juncadella, Ignacio J, Ravichandran, Kodi S

“…T cell development in the thymus is a highly regulated process that critically depends upon productive signaling via the preTCR at the β-selection stage, as…”
Get full text

Abstract PR04: Cooperation between Ras network mutations in cancer by Stites, Edward C., Trampont, Paul C., Haney, Lisa B., Walk, Scott F., Ravichandran, Kodi S.

“…Abstract Cancer genome sequencing often identifies mutations within the Ras signaling network other than the well-established KRAS, NRAS, and BRAF oncogene…”
Get full text

Nuclear Factor of Activated T-Cells (NFAT1): Potential Novel Target in T-Cell Acute Lymphocytic Leukemia (T-ALL) by Lu, Hongyan, Yang, Shicheng, Huang, Xiao, El Masri, Harun, Trampont, Paul C, Salhotra, Amandeep, Farmar, James G, Wendling, Alexander J, Laughlin, Mary J

“…Abstract 4634 T-cell transcription factor NFAT1 (NFATc2) has been reported to regulate cell cycle regulatory proteins including cyclins, cyclin-dependent…”
Get full text

CXCR4 acts as a costimulator during thymic [beta]-selection by Trampont, Paul C, Tosello-trampont, Annie-carole, Shen, Yuelei, Duley, Amanda K, Sutherland, Ann E, Bender, Timothy P, Littman, Dan R, Ravichandran, Kodi S

“…Passage through the beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene (Tcrb) and…”
Get full text

CXCR4 acts as a costimulator during thymic b-selection by Trampont, Paul C, Tosello-Trampont, Annie-Carole, Shen, Yuelei, Duley, Amanda K, Sutherland, Ann E, Bender, Timothy P, Littman, Dan R, Ravichandran, Kodi S

“…Passage through the b-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-b gene (Tcrb) and…”
Get full text

Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation: e105576 by Buckley, Monica W, Arandjelovic, Sanja, Trampont, Paul C, Kim, Taeg S, Braciale, Thomas J, Ravichandran, Kodi S

“…T cell development and activation are highly regulated processes, and their proper execution is important for a competent immune system. Shc SH2-domain binding…”
Get full text